Very few randomized controlled trials (RCTs) have been conducted using smoked cannabis (Campbell et al 2001) despite many anecdotal claims (Grinspoon and Bakalar 1997). One such study documented slight weight gain in HIV/AIDS subjects with no significant immunological sequelae (Abrams et al 2003). A recent brief trial of smoked cannabis (3.56% THC cigarettes 3 times daily) in HIV-associated neuropathy showed positive results on daily pain, hyperalgesia and 30% pain reduction (vs 15% in placebo) in 50 subjects over a treatment course of only 5 days (Abrams et al 2007) (Table 1). This short clinical trial also demonstrated prominent adverse events associated with intoxication. In Canada, 21 subjects with chronic pain sequentially smoked single inhalations of 25 mg of cannabis (0, 2.5, 6.0, 9.5% THC) via a pipe three times a day for 5 days to assess effects on pain (Ware et al 2007) with results the authors termed “modest”: no changes were observed in acute neuropathic pain scores, and a very low number of subjects noted 30% pain relief at the end of the study (Table 1). Even after political and legal considerations, it remains extremely unlikely that crude cannabis could ever be approved by the FDA as a prescription medicine as outlined in the FDA Botanical Guidance document (Food and Drug Administration 2004; Russo 2006b), due to a lack of rigorous standardization of the drug, an absence of Phase III clinical trials, and pulmonary sequelae (bronchial irritation and cough) associated with smoking (Tashkin 2005). Although cannabis vaporizers reduce potentially carcinogenic polyaromatic hydrocarbons, they have not been totally eliminated by this technology (Gieringer et al 2004; Hazekamp et al 2006).
From what I understand, CBD derived from the hemp plant does not have the side effects mentioned above, other than possibly to help reduce the amount of Coumadin/Warfarin needed – either way, a patient on this drug needs to be monitored and regularly tested anyway with their doctor. CBD derived from the marijuana plant (will contain THC) may have them, I do not know, maybe that’s why you mention them. One of the many reasons people take Hemp CBD is that it does NOT have the side effects! People take the Hemp version to help with feelings of fatigue, irritability & anxiousness, it does cause it! It helps to bring the body into balance.
The gateway effect may appear due to social factors involved in using any illegal drug. Because of the illegal status of cannabis, its consumers are likely to find themselves in situations allowing them to acquaint with individuals using or selling other illegal drugs.[268][269] Utilizing this argument some studies have shown that alcohol and tobacco may additionally be regarded as gateway drugs;[270] however, a more parsimonious explanation could be that cannabis is simply more readily available (and at an earlier age) than illegal hard drugs. In turn alcohol and tobacco are easier to obtain at an earlier point than is cannabis (though the reverse may be true in some areas), thus leading to the "gateway sequence" in those individuals since they are most likely to experiment with any drug offered.[261] 

In response to the FDA’s historic decision, the Drug Enforcement Administration (DEA) announced in September 2018 that it had removed Epidiolex from Schedule I classification, a category reserved for dangerous drugs with no medical value. Henceforth, Epidiolex would be considered a Schedule V drug, the least dangerous designation under the Controlled Substances Act.

Even those who are facing issues related to mental health should consult their physician. Research studies continue to examine the effects and benefits of this drug far beyond just anxiety and depression. The benefits for those facing schizophrenia may be just the tip of the iceberg, as this may help with such conditions as mania and other forms of psychosis with further research.


Check Dr. Stephen Porges’ work, as well as Stanley Rosenburg. Both treat trauma and the vagus nerve’s role in bodily symptoms, which cause a lot of the symptoms you mention, as well as other people here. Some of Stanley Rosenburg’s simple exercises along with Stephen Porges’ work, can realign the vagus nerve and when done regularly have a cumulative effect. Basically, most symptoms, even seizures can be caused by misalignments and/or contracted muscles, (even the tiniest muscle in the human body, the stapedius muscle when chronically contracted can cause havoc on body) all under the umbrella of the vagus nerve (polyvagal nervous system). This is very well researched and is cutting edge treatment without the use of drugs of any kind. Some of Porges’ treatments use music, believe it or not, specially designed headsets with bone conduction. But please research, there are therapists trained in this field and in meantime, you can self-apply Stanley Rosenburg’s Basic Exercise, as well as others, first and you will see drastic results.
So, your ECS signals to your brain that you’re in pain. And, when your condition is chronic, it’s a constant stream of signals to your brain about the pain. What CBD Pain Cream does is binds to those receptors that are signaling the pain to your brain. † And, it calms that reaction to help erase the pain. So, in other words, CBD Chiro-Cream actually stops the pain, rather than suppressing it like most pain killers. † And, the fact that CBD Pain Cream works with your body means it’s better and healthier for you. All you have to do is apply it topically to the areas that hurt you and you’ll see a reduction in pain fast.

Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.

It has been contended that hemp is notably superior to most crops in terms of biomass production, but van der Werf (1994b) noted that the annual dry matter yield of hemp (rarely approaching 20 t/ha) is not exceptional compared to maize, beet, or potato. Nevertheless, hemp has been rated on a variety of criteria as one of the best crops available to produce energy in Europe (Biewinga and van der Bijl 1996). Hemp, especially the hurds, can be burned as is or processed into charcoal, methanol, methane, or gasoline through pyrolysis (destructive distillation). As with maize, hemp can also be used to create ethanol. However, hemp for such biomass purposes is a doubtful venture in North America. Conversion of hemp biomass into fuel or alcohol is impractical on this continent, where there are abundant supplies of wood, and energy can be produced relatively cheaply from a variety of sources. Mallik et al. (1990) studied the possibility of using hemp for “biogas” (i.e. methane) production, and concluded that it was unsuitable for this purpose. Pinfold Consulting (1998) concluded that while there may be some potential for hemp biomass fuel near areas where hemp is cultivated, “a fuel ethanol industry is not expected to develop based on hemp.”

Right now, due to arcane laws that are about to change around the world, and strange licensing procedures, cannabis is a supply issue, but that will all change over time.  Cannabis is a plant that can grow in 12 weeks, 16 weeks for some Indica strains.  There will never be a shortage or issue with getting cannabis when it is a plant that can be produced anywhere in the world, in large batches, every 12 weeks.


Given the uncertainties and handicaps associated with hemp, it is fortunate that there are compensating factors. As noted, as a crop hemp offers some real environmental advantages, particularly with regard to the limited needs for herbicides and pesticides. Hemp is therefore pre-adapted to organic agriculture, and accordingly to the growing market for products associated with environmentally-friendly, sustainable production. Hemp products are an advertiser’s dream, lending themselves to hyperbole (“healthiest salad oil in the world,” “toughest jeans on the market”). While the narcotics image of C. sativa is often disadvantageous, advertisers who choose to play up this association do so knowing that it will attract a segment of the consuming population. In general, the novelty of hemp means that many consumers are willing to pay a premium price. It might also be said that those who have entered the hemp industry have tended to be very highly motivated, resourceful, and industrious, qualities that have been needed in the face of rather formidable obstacles to progress.
An alternative to the gateway hypothesis is the common liability to addiction (CLA) theory. It states that some individuals are, for various reasons, willing to try multiple recreational substances. The "gateway" drugs are merely those that are (usually) available at an earlier age than the harder drugs. Researchers have noted in an extensive review that it is dangerous to present the sequence of events described in gateway "theory" in causative terms as this hinders both research and intervention.[271]

To make matters more confusing, nine states (including California, Washington, and Colorado) let residents buy cannabis-based products with or without THC. Nearly two dozen other “medical marijuana states” allow the sale of cannabis, including capsules, tinctures, and other items containing CBD or THC, at licensed dispensaries to people whose doctors have certified that they have an approved condition (the list varies by state but includes chronic pain, PTSD, cancer, autism, Crohn’s disease, and multiple sclerosis). Sixteen more states legalized CBD for certain diseases. But because all these products are illegal according to the federal government, cannabis advocates are cautious. “By and large, the federal government is looking the other way,” says Paul Armentano, deputy director of the Washington, DC–based National Organization for the Reform of Marijuana Laws (NORML), but until federal laws are changed, “this administration or a future one could crack down on people who produce, manufacture, or use CBD, and the law would be on its side.”


Other desirable features of hemp fibers are strength and durability (particularly resistance to decay), which made hemp useful in the past for rope, nets, sail-cloth, and oakum for caulking. During the age of sailing ships, Cannabis was considered to provide the very best of canvas, and indeed this word is derived from Cannabis. Several factors combined to decrease the popularity of hemp in the late 19th and early 20th centuries. Increasing limitation of cheap labor for traditional production in Europe and the New World led to the creation of some mechanical inventions, but too late to counter growing interest in competitive crops. Development of other natural fibers as well as synthetic fibers increased competition for hemp’s uses as a textile fiber and for cordage. Hemp rag had been much used for paper, but the 19th century introduction of the chemical woodpulping process considerably lowered demand for hemp. The demise of the sail diminished the market for canvas. Increasing use of the plant for drugs gave hemp a bad image. All this led to the discontinuation of hemp cultivation in the early and middle parts of the 20th century in much of the world where cheap labor was limited. In the 19th century softer fabrics took over the clothing market, and today, hemp constitutes only about 1% of the natural fiber market. At least some production of hemp for fiber still occurs in Russia, China, the Ukraine, Poland, Hungary, the countries of the former Yugoslavia, Romania, Korea, Chile, and Peru. There has been renewed interest in England, Australia, and South Africa in cultivating fiber hemp. Italy has an outstanding reputation for high-quality hemp, but productivity has waned for the last several decades. In France, a market for high-quality paper, ironically largely cigarette paper, has developed (such paper is completely free of the intoxicating resin). Modern plant breeding in Europe has produced several dozen hemp strains, although by comparison with other fiber crops there are relatively few described varieties of hemp. Since World War II, breeding has been concerned most particularly with the development of monoecious varieties. Gehl (1995) reviewed fiber hemp development in Canada in the early 20th century, and concluded that the prospects for a traditional fiber industry were poor. However, as outlined below, there are now many non-traditional usages for hemp fiber which require consideration. Hemp long fiber is one of the strongest and most durable of natural fibers, with high tensile strength, wet strength, and other characteristics that make it technically suited for various industrial products (Karus and Leson 1996).

“We would strongly warn against using a vaporizer to vape CBD hemp oil products because we haven’t seen one yet that doesn’t contain thinning agents that can be very toxic,” Lee said. “Thinning agents like propylene glycol and polyethylene glycol should not be in a product that you’re going to eat or inhale. Flavoring agents that are added to CBD hemp products should be a red flag. I think they should be avoided because the FDA hasn’t approved any of these flavoring agents for being heated and inhaled.”
In addition to providing useful fibers, hemp seed also has high nutritional value. and the plant can be used to make biodegradable plastics, some fuels, and a variety of other things. Hemp foods including but not limited to hemp energy bars, hemp salad dressing,hemp milk, hemp protein shakes, hemp oil gel caps and hemp protein powder are among some of the health products being produced today. Visit the Hemp Education pages to learn more!
Hemp, (Cannabis sativa), also called industrial hemp, plant of the family Cannabaceae cultivated for its fibre (bast fibre) or its edible seeds. Hemp is sometimes confused with the cannabis plants that serve as sources of the drug marijuana and the drug preparation hashish. Although all three products—hemp, marijuana, and hashish—contain tetrahydrocannabinol (THC), a compound that produces psychoactive effects in humans, the variety of cannabis cultivated for hemp has only small amounts of THC relative to that grown for the production of marijuana or hashish.
That leaves those touting CBD’s effectiveness pointing primarily to research in mice and petri dishes. There, CBD (sometimes combined with small amounts of THC) has shown promise for helping pain, neurological conditions like anxiety and PTSD, and the immune system—and therefore potentially arthritis, diabetes, multiple sclerosis, cancer, and more.
Early this month, the FDA just approved a new drug for depression called esketamine. Esketamine, marketed under the brand name Spravato, is a ketamine-based drug designed for patients who aren’t responding to conventional antidepressant medications. It comes in a nasal spray form, and is touted to be the world’s first quick-relief depression medication in the market.
"In response to DEA actions to block seeds imported by some states in order to grow industrial hemp and to avoid future similar DEA actions to stall full implementation of the hemp provision of the farm bill, Congress acted swiftly. Both the House and Senate FY2015 Commerce-JusticeScience (CJS) appropriations bills contained provisions to block federal law enforcement authorities from interfering with state agencies and hemp growers and counter efforts to obstruct agricultural research. The enacted FY2015 appropriation blocked federal law enforcement authorities from interfering with state agencies, hemp growers, and agricultural research.46 The provision stated that 'none of the funds made available' to the U.S. Justice Department and DEA 'may be used in contravention' of the 2014 farm bill.
Marijuana or marihuana (herbal cannabis),[167] consists of the dried flowers and subtending leaves and stems of the female Cannabis plant.[168][169][170][171] This is the most widely consumed form,[171] containing 3% to 20% THC,[172] with reports of up-to 33% THC.[173] This is the stock material from which all other preparations are derived. Although herbal cannabis and industrial hemp derive from the same species and contain the psychoactive component (THC), they are distinct strains with unique biochemical compositions and uses. Hemp has lower concentrations of THC and higher concentrations of CBD, which decreases the psychoactive effects[174][175]
^ Parliament of the Czech Republic (1998), Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors (in Czech), Prague "Podle čl. 36 Jednotné úmluvy o omamných látkách ze dne 31. března 1961 (č. 47/1965 Sb.) se signatáři zavazují k trestnímu postihu tam uvedených forem nakládání s drogami včetně jejich držby. Návrh upouští od dosavadní beztrestnosti držby omamných a psychotropních látek a jedů pro svoji potřebu. Dosavadní beztrestnost totiž eliminuje v řadě případů možnost postihu dealerů a distributorů drog."
Short-term use of the drug impairs thinking and coordination. In long-term studies, teens who smoke marijuana have lower IQs later on, as well as structural differences in their brains, though scientists debate whether this is an effect of the drug or a result of habitual pot smokers seeking out less intellectually stimulating pursuits. A 2016 study on almost 300 students by the University of Montreal published in the journal Development and Psychopathology found that teens who start smoking around age 14 do worse on some cognitive tests by age 20 than non-smokers. They also have a higher school dropout rate. If they wait until age 17 to start, though, the smokers do not seem to have the same impairments, according to the study.  

A bit of online digging led me to realize that the active ingredient in Charlotte's Web Everyday Plus Hemp Oil, the product I'd been offered to test, was the chemical compound CBD, which stands for Cannabidiol. Unlike THC, the other crucial compound in hemp and marijuana plants, CBD does not produce the psychoactive effects that make you feel "high"; instead, it actually eases anxiety and makes you less likely to freak out.
Unfortunately due to the disappointing and down right inaccurate position of the federal government in classifying Cannabis as a schedule one drug, most research institutions risk federal funding if they conduct real research on Cannabis. This has dramatically limited the potential for real research by real scientists to be conducted. That research is critical to better understanding the multitude of therapeutic effects of the various chemical constituents found in Cannabis.
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
While most supplements have a single recommended dose, CBD is different. The amount of CBD you take depends on your doctor’s recommendations and your own research into how CBD will work for your unique needs. In general, it’s smart to start with a medium dose of CBD. This way, you can increase or decrease the dose as needed. In addition, it’s recommended to start with one half ML (half a dropper) of CBD oil, because you can always take more if needed.
Debate continues as to the existence of a clinically significant cannabis withdrawal syndrome with proponents (Budney et al 2004), and questioners (Smith 2002). While withdrawal effects have been reported in recreational cannabis smokers (Solowij et al 2002), 24 volunteers with MS who abruptly stopped Sativex after more than a year of continuous usage displayed no withdrawal symptoms meeting Budney’s criteria. While symptoms recurred after 7–10 days of abstinence from Sativex, prior levels of symptom control were readily re-established upon re-titration of the agent (Wade et al 2006).
Hemp has very low levels of another cannabis compound, tetrahydrocannabinol (THC) — the main psychoactive compound in marijuana. Evidence suggests that THC — not CBD — causes the symptoms people associate with getting high on marijuana, Blessing says. Unlike marijuana, which the CDC argues is addictive, CBD also doesn’t seem to be, according to the World Health Organization.
The DCE/SP began funding eradication programs in Hawaii and California in 1979.  The program rapidly expanded to include programs in 25 states by 1982.  By 1985, all 50 states were participating in the DCE/SP.  In 2015, the DEA continued its nation-wide cannabis eradication efforts, providing resources to support the 128 state and local law enforcement agencies that actively participate in the program.  This assistance allows the enhancement of already aggressive eradication enforcement activities throughout the nation.  In 2017, the DEA continued its nation-wide cannabis eradication efforts, providing resources to support the 126 state and local law enforcement agencies that actively participate in the program.   This assistance allows the enhancement of already aggressive eradication enforcement activities throughout the nation.  In 2017, the DCE/SP was responsible for the eradication of 3,078,418 cultivated outdoor cannabis plants and 303,654 indoor plants for a total of 3,382,072 marijuana plants.  In addition, the DCE/SP accounted for 4,502 arrests and the seizure in excess of 20.5 million dollars of cultivator assets.  The program also removed 2,829 weapons from cannabis cultivators.

^ Jump up to: a b This paper begins with a history of hemp use and then describes how hemp was constructed as a dangerous crop in the U.S. The paper then discusses the potential of hemp as an alternative crop. Luginbuhl, April M. (2001). "Industrial hemp (Cannabis sativa L): The geography of a controversial plant". The California Geographer (PDF). 41. California Geographical Society. pp. 1–14. Retrieved 2013-03-28. Hemp contains less than 1% THC, or tetrahydrocannabinols, the psychoactive property in marijuana. In other words, smoking hemp cannot create a 'high.' ... The dense growth of hemp eliminates other weeds.... The best growing technique for hemp, planting 300 to 500 plants per square meter, also helps authorities easily tell the hemp from marijuana, which is a plant that is less densely cultivated. (Roulac 1997; 149).

"Hemp oil is extremely nutritious, and is used in foods and nutraceutical products for humans and animals, as well as in personal care products. Hemp oil is also suitable for use in industrial products such as paints, varnishes, inks and industrial lubricants, and can be used to produce biodiesel. The crushed seed meal left over from oil production is frequently used for animal feed."
In a study with HIV-positive adult men, blood concentrations of ghrelin and other appetitive hormones (leptin, PYY, and insulin) were tested after having received smoked medicinal cannabis or matched placebo for HIV-associated neuropathic pain. Cannabis administration, as compared to placebo, significantly increased ghrelin concentrations in this study. In addition, leptin and PYY levels were, respectively, increased and decreased, but no impact on insulin levels was found (Riggs et al., 2012).
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There are practical, if cruder alternatives to separate the long fiber for high-quality textile production, but in fact such techniques are used mostly for non-textile applications. This involves production of “whole fibers” (i.e. harvesting both the long fibers from the cortex and the shorter fibers from throughout the stem), and technologies that utilize shortened hemp fibers. This approach is currently dominant in western Europe and Canada, and commences with field dew retting (typically 2–3 weeks). A principal limitation is climatic—the local environment should be suitably but not excessively moist at the close of the harvest season. Once stalks are retted, dried, and baled, they are processed to extract the fiber. In traditional hemp processing, the long fiber was separated from the internal woody hurds in two steps, breaking (stalks were crushed under rollers that broke the woody core into short pieces, some of which were separated) and scutching (the remaining hurds, short fibers (“tow”) and long fibers (“line fiber, ” “long-line fiber”) were separated). A single, relatively expensive machine called a decorticator can do these two steps as one. In general in the EU and Canada, fibers are not separated into tow and line fibers, but are left as “whole fiber.” In western Europe, the fiber is often “cottonized,” i.e. chopped into short segments the size of cotton and flax fiber, so that the fibers can be processed on flax processing machinery, which is very much better developed than such machinery is for hemp. In North America the use of hemp for production of even crude textiles is marginal. Accordingly, the chief current fiber usages of North American, indeed of European hemp, are non-textile.
Now 13, Jackson — whose diagnosis is undetermined — continues to use marijuana every day. (Like many patients, he ingests it in droplet form, which allows for more precise dosing and avoids lung problems.) He still has seizures, but they are less severe and they occur once every week or two, down from around 200 a month before he started using cannabis. He is back in school full time and is well enough to go on hikes and bike rides with his family.
The Hemp Farming Act of 2018, part of the 2018 Farm Bill[106] signed by President Donald Trump December 20, 2018,[107] changed hemp from a controlled substance to an agricultural commodity, legalizing hemp federally, which made it easier for farmers to get production licenses, get loans to grow hemp, and allowed them to get federal crop insurance.[106]

THC, an intoxicating and illegal substance, is responsible for causing marijuana users to get “high.” Unlike THC, CBD is non-psychoactive because it does not act on the same pathways as THC. Thus, it is impossible to get “high” by smoking or ingesting CBD or CBD oil extracted from industrial hemp plants, as they only have minuscule traces of THC (<0.3%).


^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.

The first time I came across CBD was when I was visiting my brother in San Antonio, Texas 2 years back. The one day I had some serious back pain, My brother's neighbour suggested that I should try CBD oil for my pain as it helps his mom with her cancer pain, and directed me to SABotanicals, a local CBD store in San Antonio where I bought a 2000mg CBD oil.In the beginning, I was a sceptic, but it worked so well that I ordered three more bottles to last me for a few months. I must say that also felt relaxed but could do my work with no issues as it didn't make me high.To date, I'm still using CBD oil for my paid and came off pain medications completely.God gave us something great!


Many monoecious varieties have also been described,[20] in which individual plants bear both male and female flowers.[21] (Although monoecious plants are often referred to as "hermaphrodites", true hermaphrodites – which are less common in Cannabis – bear staminate and pistillate structures together on individual flowers, whereas monoecious plants bear male and female flowers at different locations on the same plant.) Subdioecy (the occurrence of monoecious individuals and dioecious individuals within the same population) is widespread.[22][23][24] Many populations have been described as sexually labile.[25][26][27]

^ "Sativex Oral Mucosal Spray Public Assessment Report. Decentralized Procedure" (PDF). United Kingdom Medicines and Healthcare Products Regulatory Agency. p. 93. Retrieved 2015-05-07. There is clear evidence that recreational cannabis can produce a transient toxic psychosis in larger doses or in susceptible individuals, which is said to characteristically resolve within a week or so of absence (Johns 2001). Transient psychotic episodes as a component of acute intoxication are well-documented (Hall et al 1994)
However, like we just mentioned CBD oil for pain management that has been sourced from industrial hemp grown under the farm bill is in fact legal to buy and sell. The best CBD oil brands that we cover here on this site, claim to extract their concentrates from U.S.-based industrial hemp supplies, which if true, are 100% legal since they contain negligible amounts of THC.

Hi, I have had spondylolisthesis since age 11 which left me with extreme nerve pain...restless leg syndrome. Had 3 spinal ops and also had hip surgery 2 years ago. have asthma and hypothyroidism. I can deal with everything else but this nerve pain is insane. Used Gabapentin for 9 years and now its not in the market in Nairobi, Kenya where I live. Am on Lyrica, which is not working. I started Cbd oil in August but now found my body has become immune to the effects of pain releif I was getting. Can anyone suggest what strength oil/cbd supplement I should aim for? Currently am making flapjacks with weed, have one every night but this makes me high which I dont want. I still wake up in pain at night, please help.
In this report, researchers reviewed 16 previously published studies testing the use of various cannabis-based medicines in the treatment of chronic neuropathic pain and found some evidence that cannabis-based medicines may help with pain relief and reduce pain intensity, sleep difficulties, and psychological distress. Side effects included sleepiness, dizziness, mental confusion. The authors concluded that the potential harm of such medicines may outweigh their possible benefit, however, it should be noted that the studies used a variety of cannabis-based medicines (e.g. inhaled cannabis and sprays and oral tablets containing THC and/or CBD from plant sources or made synthetically), some of which are more likely to result in these side effects than products without THC.

About 9% of those who experiment with marijuana eventually become dependent according to DSM-IV (1994) criteria.[78] A 2013 review estimates daily use is associated with a 10-20% rate of dependence.[42] The highest risk of cannabis dependence is found in those with a history of poor academic achievement, deviant behavior in childhood and adolescence, rebelliousness, poor parental relationships, or a parental history of drug and alcohol problems.[138] Of daily users, about 50% experience withdrawal upon cessation of use (i.e. are dependent), characterized by sleep problems, irritability, dysphoria, and craving.[117] Cannabis withdrawal is less severe than withdrawal from alcohol.[139]


Even those who are facing issues related to mental health should consult their physician. Research studies continue to examine the effects and benefits of this drug far beyond just anxiety and depression. The benefits for those facing schizophrenia may be just the tip of the iceberg, as this may help with such conditions as mania and other forms of psychosis with further research.
Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.
In Europe and Asia, hemp farming has been conducted for millennia. Although most countries ceased growing hemp after the second word war, some didn’t, including France, China, Russia, and Hungary, so that essential knowledge of how to grow and process hemp was maintained. When commercial hemp cultivation resumed in Canada in 1997, many farmers undertook to grow the crop without appreciating its suitability for their situation, or for the hazards of an undeveloped market. Hemp was often grown on farms with marginal incomes in the hopes that it was a savior from a downward financial spiral. The myth that hemp is a wonder crop that can be grown on any soil led some to cultivate on soils with a history of producing poor crops; of course, a poor crop was the result.
At least 38 states considered legislation related to industrial hemp in 2018. These bills ranged from clarifying existing laws to establishing new licensing requirements and programs. At least six states – Alaska, Arizona, Kansas, Missouri, New Jersey and Oklahoma – enacted legislation in 2018 establishing hemp research and industrial hemp pilot programs. Georgia created the House Study Committee on Industrial Hemp Production. States, already allowing for industrial hemp programs, continued to consider policies related to licensure, funding, seed certification, and other issues. For example, Tennessee amended its Commercial Feed Law to include hemp. 
The question of whether heteromorphic sex chromosomes are indeed present is most conveniently answered if such chromosomes were clearly visible in a karyotype. Cannabis was one of the first plant species to be karyotyped; however, this was in a period when karyotype preparation was primitive by modern standards (see History of Cytogenetics). Heteromorphic sex chromosomes were reported to occur in staminate individuals of dioecious "Kentucky" hemp, but were not found in pistillate individuals of the same variety. Dioecious "Kentucky" hemp was assumed to use an XY mechanism. Heterosomes were not observed in analyzed individuals of monoecious "Kentucky" hemp, nor in an unidentified German cultivar. These varieties were assumed to have sex chromosome composition XX.[32] According to other researchers, no modern karyotype of Cannabis had been published as of 1996.[33] Proponents of the XY system state that Y chromosome is slightly larger than the X, but difficult to differentiate cytologically.[34]
Executives from Canopy Growth CGC, -1.22% WEED, -1.27%  and rival Aurora Cannabis Inc. ACB, -0.88% ACB, -0.83%  both discussed their hemp operations on September-quarter earnings calls that included disappointing results related to early recreational pot sales. Aurora declined to comment on the latest developments and Canopy did not make executives available by the time of publication.
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.

I just started taking CBD oil , I am on my 2nd Hip replacement surgery due to device failures looking at a 3rd surgery. Has you can imagine the pain, stress and anxiety levels are off the charts. Especially at an otherwise healthy 54 yr women. So i understand from reading posts its best to take it under the tongue. I am taking 1-2 ml a day. I can tell some difference,is your recommended dosage. I am using for pain , stress and sleep. I appreciate your feedback.

Since then, we’ve seen progress in other areas. Last month, Barneys New York brought cannabis into the world of high-end luxury goods when it announced they would open a boutique focused on selling luxury accessories to cannabis aficionados. “Barneys is courting the Manolo Blahnik-wearing, marijuana smoking crowd,” trumpeted a headline on MarketWatch.

In late 2017, researchers with the University of Guelph in Canada published the first-ever study to document the ideal growing conditions for cannabis. Using liquid organic fertilizer with a PKN ratio of 1.3P–1.7K-4.0N, the experiment tested five increasing rates of fertilization. They also tested two coir-based soil-less growing media, or “substrates.”
CBD Oil refers to CBD-infused products that contain CBD suspended in an oily base, such as vegetable glycerin, hempseed oil, or another plant-derived oil. Sublingual oils are ideal because they allow for rapid absorption of CBD through the membrane under your tongue directly into your bloodstream. CBD Oils are available in both low and high doses, and droppers built into the cap make it easy to measure your proper dose. CBD Oils are the most popular kind of CBD product thanks to their ease of use and rapid effects.
Oh, and that ideal ratio of omegas? Researchers in Spain say that composition makes hemp oil high in polyunsaturated fatty acids (PUFAs). A high ratio of PUFAs to saturated fats has been linked to reductions in cholesterol levels and atherosclerosis (hardening and narrowing of the arteries). That suggests hemp oil may have the potential to help prevent heart disease, according to the study authors. But again, none of this has been tested in people.
Now 13, Jackson — whose diagnosis is undetermined — continues to use marijuana every day. (Like many patients, he ingests it in droplet form, which allows for more precise dosing and avoids lung problems.) He still has seizures, but they are less severe and they occur once every week or two, down from around 200 a month before he started using cannabis. He is back in school full time and is well enough to go on hikes and bike rides with his family.
Tammy et al, Through trial and error you will find a correct dosage. Try 50 mg daily....25 each 2x daily....if no results up the dosage until it works for you. Remember, there has never been a death from marijuana or CBD use. You might want to try a tincture or rub with CBD and THC. You won't get the psych high from it. Helps my friend with PArkinsons tremors. She takes 50mg of tincture and uses the rub morning and night. It is a miracle for arthritis. Good luck
"Beginning around 1995, an increasing number of state legislatures began to consider a variety of initiatives related to industrial hemp. Most of these have been resolutions calling for scientific, economic, or environmental studies, and some are laws authorizing planting experimental plots under state statutes. Nonetheless, the actual planting of hemp, even for state-authorized experimental purposes, remains regulated by DEA under the CSA.

Hemp, (Cannabis sativa), also called industrial hemp, plant of the family Cannabaceae cultivated for its fibre (bast fibre) or its edible seeds. Hemp is sometimes confused with the cannabis plants that serve as sources of the drug marijuana and the drug preparation hashish. Although all three products—hemp, marijuana, and hashish—contain tetrahydrocannabinol (THC), a compound that produces psychoactive effects in humans, the variety of cannabis cultivated for hemp has only small amounts of THC relative to that grown for the production of marijuana or hashish.


Despite some relatively tough talk from regulatory bodies, it can seem like they’re trying to close the barn door after the horse got out. CBD is already everywhere, and people are curious about it for reasons that seem to go far beyond trendiness, such as financial precariousness and health-care costs. “People are panicking and looking for things. They’re like, ‘What if I don’t have insurance because I get laid off? What can I replace my meds with?’” says Donahue, the Allure editor. CBD fits neatly with a growing distrust in technology and in the pharmaceutical industry, and America’s moderating view of cannabis means that many people see CBD as a safer alternative for anxiety or pain that’s worth trying.
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