Experimental studies have also been conducted in order to assess the effect of cannabis use on schizophrenia. D’Souza et al. (2004) administered varying levels of the main ingredient in cannabis to healthy individuals with a history of cannabis exposure (but not abuse) and found that the subjects in the study displayed both positive and negative symptoms associated with schizophrenia, although all symptoms disappeared by about 3 h. D’Souza et al. (2005) conducted a follow-up study in which they followed the same protocol, but with clinically stable schizophrenia patients. Again, they found brief increases in positive symptoms, even if the patients were already taking antipsychotics.
In Japan, hemp was historically used as paper and a fiber crop. There is archaeological evidence cannabis was used for clothing and the seeds were eaten in Japan back to the Jōmon period (10,000 to 300 BC). Many Kimono designs portray hemp, or asa (Japanese: 麻), as a beautiful plant. In 1948, marijuana was restricted as a narcotic drug. The ban on marijuana imposed by the United States authorities was alien to Japanese culture, as the drug had never been widely used in Japan before. Though these laws against marijuana are some of the world's strictest, allowing five years imprisonment for possession of the drug, they exempt hemp growers, whose crop is used to make robes for Buddhist monks and loincloths for Sumo wrestlers. Because marijuana use in Japan has doubled in the past decade, these exemptions have recently been called into question.[150]
“We continue to see great progress towards a new perspective on cannabis within the US. Within healthcare, several conditions and certain patient profiles rely heavily on CBD-only products of which the proposed Farm Bill will work to dramatically improve access to patients – not only in the US but globally,” said Prad Sekar, CEO of CB2 Insights in a written interview.
Preliminary work in Germany (noted in Karus and Leson 1994) suggested that hemp could be grown on soils contaminated with heavy metals, while the fiber remained virtually free of the metals. Kozlowski et al. (1995) observed that hemp grew very well on copper-contaminated soil in Poland (although seeds absorbed high levels of copper). Baraniecki (1997) found similar results. Mölleken et al. (1997) studied effects of high concentration of salts of copper, chromium, and zinc on hemp, and demonstrated that some hemp cultivars have potential application to growth in contaminated soils. It would seem unwise to grow hemp as an oilseed on contaminated soils, but such a habitat might be suitable for a fiber or biomass crop. The possibility of using hemp for bioremediation deserves additional study.

A study by Henquet and colleagues (2004) substantially replicated both the Swedish and Dutch studies in a 4-year follow-up of a cohort of 2437 adolescents and young adults between 1995 and 1999 in Munich. They found a dose–response relationship between self-reported cannabis use at baseline and the likelihood of reporting psychotic symptoms. As in the Dutch cohort, young people who reported psychotic symptoms at baseline were much more likely to experience psychotic symptoms at follow-up if they used cannabis than were cannabis-using peers without such a history.


In the United States, non-FDA approved CBD products are classified as Schedule I drugs under the Controlled Substances Act.[62] This means that production, distribution, and possession of non-FDA approved CBD products is illegal under federal law. In addition, in 2016 the Drug Enforcement Administration added "marijuana extracts" to the list of Schedule I drugs, which it defined as "an extract containing one or more cannabinoids that has been derived from any plant of the genus Cannabis, other than the separated resin (whether crude or purified) obtained from the plant."[63] Previously, CBD had simply been considered "marijuana", which is a Schedule I drug.[62][64]
“THC can be present in products advertised as CBD products, which are not regulated by the FDA. The presence of THC in urine would trigger a positive result on a drug test. Testing will not determine if THC is from CBD or marijuana use," March wrote to WECT about the NHRMC note. “We have advised employees that using CBD products could put them at risk for a positive drug test result.”

"The global market for hemp consists of more than 25,000 products in nine submarkets: agriculture, textiles, recycling, automotive, furniture, food and beverages, paper, construction materials, and personal care (Table 1). Hemp can be grown as a fiber, seed, or dual-purpose crop.6 The stalk and seed are the harvested products. The interior of the stalk has short woody fibers called hurds; the outer portion has long bast fibers. Hemp seed/grains are smooth and about one-eighth to one-fourth of an inch long.7
Environmental sex determination is known to occur in a variety of species.[39] Many researchers have suggested that sex in Cannabis is determined or strongly influenced by environmental factors.[27] Ainsworth reviews that treatment with auxin and ethylene have feminizing effects, and that treatment with cytokinins and gibberellins have masculinizing effects.[15] It has been reported that sex can be reversed in Cannabis using chemical treatment.[40] A PCR-based method for the detection of female-associated DNA polymorphisms by genotyping has been developed.[41]
If your intention is to help treat chronic pain, then you may want to start out with a lower dose, and then proceed from there. If you notice effective results, you can downsize the dose, or likewise you can always up the dose until positive results are achieved. The key is to only increase your dosage in small increments so that you are able to pinpoint exactly how much CBD oil it takes to treat your condition. Be advised, though, that you should not exceed the recommended daily doses that are listed on the bottle and you should consult with a physician.

My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary
Activities such as lifting heavy objects at work, being always on your feet, or doing yard work on the weekends can all put strain and duress on your joints. When you continuously put pressure on your joints, it can hinder and even damage your joint movement. With Hemp Bombs’ CBD Pain Freeze, we provide you with an applicable solution designed to deter joint pain and help improve your day to day mobility.
Mike, what kind of breast cancer (invasive ductal, I presume)? How many of her lymph nodes were positive? How big was the primary tumor? Reason I ask is that in women with Stage I or IIA tumors that are estrogen-and progesterone-receptor-positive and HER2-negative (ER+/PR+/HER2-) with three or fewer positive lymph nodes, there is a genomic assay test on a sample of the tumor, called OncotypeDX, that will tell doctors whether chemo is necessary or would even work at all. Medicare covers that test 100%.That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors(aka AIs: anastrazole, letrozole, or exemestane)which have as a side effect joint pain. CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.So don’t assume your mom’s cancer will require chemo; but if it does, CBD helps with those side effects as well. If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil (legal and over-the-counter in all 50 states). Some (though not most) medical oncologists will certify their own patients’ medical marijuana card applications so she need not seek out another doctor; and will advise the appropriate dose for her symptoms. Once she gets her card, the “budtenders” in the licensed dispensaries can advise her as to the right CBD product (with or without THC), strength, and dosage. If she lives in a state where recreational weed is legal, the “budtenders” in the marijuana shops can steer her to the right strength of CBD oil and the right dosage.
"Probably indigenous to temperate Asia, C. sativa is the most widely cited example of a “camp follower.” It was pre-adapted to thrive in the manured soils around man’s early settlements, which quickly led to its domestication (Schultes 1970). Hemp was harvested by the Chinese 8500 years ago (Schultes and Hofmann 1980). For most of its history, C. sativa was most valued as a fiber source, considerably less so as an intoxicant, and only to a limited extent as an oilseed crop. Hemp is one of the oldest sources of textile fiber, with extant remains of hempen cloth trailing back 6 millennia. Hemp grown for fiber was introduced to western Asia and Egypt, and subsequently to Europe somewhere between 1000 and 2000 BCE. Cultivation in Europe became widespread after 500 CE. The crop was first brought to South America in 1545, in Chile, and to North America in Port Royal, Acadia in 1606. The hemp industry flourished in Kentucky, Missouri, and Illinois between 1840 and 1860 because of the strong demand for sailcloth and cordage (Ehrensing 1998). From the end of the Civil War until 1912, virtually all hemp in the US was produced in Kentucky."
This article will attempt to present information concerning cannabinoid mechanisms of analgesia, review randomized clinical trials (RCTs) of available and emerging cannabinoid agents, and address the many thorny issues that have arisen with clinical usage of herbal cannabis itself (“medical marijuana”). An effort will be made to place the issues in context and suggest rational approaches that may mitigate concerns and indicate how standardized pharmaceutical cannabinoids may offer a welcome addition to the pharmacotherapeutic armamentarium in chronic pain treatment.
Extraction: The method by which CBD oil is processed from hemp plants can be very telling. Some manufacturers extract and process the oil using toxic materials like propane or butane; in most cases, these oils are cheaply priced. Safer extraction and processing agents include ethanol, which cleans the hemp plant of unwanted toxins; and supercritical carbon dioxide extraction, which strips harmful materials from the plant by changing the carbon dioxide’s temperature and pressure settings.
Tocopherols. Tocopherols are major antioxidants in human serum. Alpha- beta-, gamma- and delta-tocopherol represent the vitamin E group. These fat-soluble vitamins are essential for human nutrition, especially the alpha-form, which is commonly called vitamin E. About 80% of the tocopherols of hempseed oil is the alpha form. The vitamin E content of hempseed is comparatively high. Antioxidants in hempseed oil are believed to stabilize the highly polyunsaturated oil, tending to keep it from going rancid. Sterols in the seeds probably serve the same function, and like the tocopherols are also desirable from a human health viewpoint.
While normally I'd be slightly tripped up by little things like an overly crowded subway car or a full inbox at work, the CBD oil seems to have taken the edge off of my anxiety a bit. Rather than overthinking a sternly worded email or analyzing a social interaction, I've found it easier to recognize the irrationality of these thoughts and actually let them go (instead of ruminating on the situation). In some ways, I feel more like myself. With that said, I've still experienced some social anxiety when meeting new groups of people—I'd be interested to see what taking the full recommended dose would do.
The plant is also known as hemp, although this term is often used to refer only to varieties of Cannabis cultivated for non-drug use. Cannabis has long been used for hemp fibre, hemp seeds and their oils, hemp leaves for use as vegetables and as juice, medicinal purposes, and as a recreational drug. Industrial hemp products are made from cannabis plants selected to produce an abundance of fiber. To satisfy the UN Narcotics Convention, some cannabis strains have been bred to produce minimal levels of tetrahydrocannabinol (THC), the principal psychoactive constituent. Some strains have been selectively bred to produce a maximum of THC (a cannabinoid), the strength of which is enhanced by curing the flowers. Various compounds, including hashish and hash oil, are extracted from the plant.[8]
Pinfold Consulting. 1998. (G. Pinfold Consulting Economists Ltd. and J. White, InfoResults Ltd.). A maritime industrial hemp product marketing study. Prepared for Nova Scotia Agriculture and Marketing (Marketing and Food Industry Development), and New Brunswick Agriculture & Rural Development (Marketing and Business Development). agri.gov.ns.ca/pt/agron/hemp/hempms.htm
His third question is whether cannabis serves as a gateway drug. There are two possibilities. The first is that marijuana activates certain behavioral and neurological pathways that ease the onset of more serious addictions. The second possibility is that marijuana offers a safer alternative to other drugs: that if you start smoking pot to deal with chronic pain you never graduate to opioids.

Check Dr. Stephen Porges’ work, as well as Stanley Rosenburg. Both treat trauma and the vagus nerve’s role in bodily symptoms, which cause a lot of the symptoms you mention, as well as other people here. Some of Stanley Rosenburg’s simple exercises along with Stephen Porges’ work, can realign the vagus nerve and when done regularly have a cumulative effect. Basically, most symptoms, even seizures can be caused by misalignments and/or contracted muscles, (even the tiniest muscle in the human body, the stapedius muscle when chronically contracted can cause havoc on body) all under the umbrella of the vagus nerve (polyvagal nervous system). This is very well researched and is cutting edge treatment without the use of drugs of any kind. Some of Porges’ treatments use music, believe it or not, specially designed headsets with bone conduction. But please research, there are therapists trained in this field and in meantime, you can self-apply Stanley Rosenburg’s Basic Exercise, as well as others, first and you will see drastic results.

The seeds are sown with grain drills or other conventional seeding equipment to a depth of 1.27 to 2.54 cm. Greater seeding depths result in increased weed competition. Nitrogen should not be placed with the seed, but phosphate may be tolerated. The soil should have available 89 to 135 kg/ha of nitrogen, 46 kg/ha phosphorus, 67 kg/ha potassium, and 17 kg/ha sulfur. Organic fertilizers such as manure are one of the best methods of weed control.[58]
Cannatonic: A potent pain-reliever, Cannatonic hails from Spain and stands as one of the earliest cultivars to be bred for its high CBD content. This cultivar is a cross between MK Ultra and G13 Haze, and it helps relieves anxiety, muscle spasms, pain, and migraines while providing uplifting energy. Cannatonic tends to relax and loosen muscles without locking users to their couches.
A 2012 study reported that, “systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance…These cannabinoids may represent a novel class of therapeutic agents for the treatment of chronic pain and other diseases…”
While the science behind CBD oil assuaged many of my concerns, Charlotte Figi's inspiring story was the kicker. Figi, a 6-year-old girl diagnosed with a rare and resistant form of epilepsy known as Dravet syndrome, was actually placed on hospice care and given a "do not resuscitate" order when her parents, desperate and frustrated with pharmaceutical medication, considered medical marijuana. Charlotte is now 99% seizure-free since she began supplementing with Charlotte Web's CBD oil, which the brand named after Figi.
CBD is a compound called a cannabinoid, says Jordan Tishler, MD, a Harvard-trained doc who is an expert on using cannabis as medical treatment. It can be extracted from hemp or marijuana, two different plants from the Cannabis sativa L. ("cannabis") species. The big difference between the two: Marijuana contains higher levels of tetrahydrocannabinol ("THC"), the compound responsible for the psychoactive properties of pot (a.k.a., the stuff that makes you high). Hemp, on the other hand, is naturally very low in THC (0.3 percent), says Tishler.
In the mid 1990s, the EU provided subsidization for hemp cultivation of ca. $1,050/ha. This support was instrumental in developing a hemp industry in western Europe. However, no comparable support is available in North America, and indeed those contemplating entering into hemp cultivation are faced with extraordinary costs and/or requirements in connection with licensing, security, THC analysis, and record keeping. Those involved in value-added processing and distribution are also faced with legal uncertainties and the regular threat of idiosyncratic, indeed irrational actions of various governments. Simply displaying a C. sativa leaf on advertising has led to the threat of criminal charges in the last decade in several G8 countries. Attempting to export or import hemp products among countries is presently a most uncertain activity.
The CBD oil needs to be taken twice a day everyday. The dosage depends on symptoms and it takes 30 days to awken your natural cannabis system after you begin taking the oil. I personally use Hemp works CBD oil in the 750 strength and only need 5 drops sublingual 2 times daily and results are many. Problem with oil and alz.patients is getting them to hold oil under tongue for 60 seconds. We have just began to get my dad on it. He too is in a nursing home in the state of florida and they cannot deny him any medication my mom has requested that he receive. If she is not their they are supposed to administer and she will call them to make sure he gets it. He is not 30 days into dosing yet so I don't have any results to speak of. I do know that since he has started he has had no more bladder infection and has not fallen in 3 weeks. That's a record for him so we will continue to monitor. Best of luck to you and a lot is going to depend on the state your mom is in and what the state laws are concerning her rights or the rights of whom has her medical power of attorney
^ Jump up to: a b c d Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). "Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–78. doi:10.1098/rstb.2011.0389. PMC 3481531. PMID 23108553.
With so many companies popping up every day, we’ve done the hard work for you. We bring you the best CBD oil guide and the top 25 brands that made our list based on CBD oil quality, effectiveness, customer service and of course price. Please note, this article is updated constantly, so don’t forget come back from time to time to see the most updated information.
Nabilone (Cesamet) (Figure 1), is a synthetic dimethylheptyl analogue of THC (British Medical Association 1997) that displays greater potency and prolonged half-life. Serum levels peak in 1–4 hours (Lemberger et al 1982). It was also primarily developed as an anti-emetic in chemotherapy, and was recently re-approved for this indication in the USA. Prior case reports have noted analgesic effects in case reports in neuropathic pain (Notcutt et al 1997) and other pain disorders (Berlach et al 2006). Sedation and dysphoria were prominent sequelae. An RCT of nabilone in 41 post-operative subjects actually documented exacerbation of pain scores after thrice daily dosing (Beaulieu 2006) (Table 1). An abstract of a study of 82 cancer patients on nabilone claimed improvement in pain levels after varying periods of follow-up compared to patients treated without this agent (Maida 2007). However, 17 subjects dropped out, and the study was neither randomized nor controlled, and therefore is not included in Table 1.
Hemp hasn't always been on the wrong side of the authorities. The Puritans brought hemp with them to New England in 1645 and Europeans were growing it even earlier in Chile. George Washington planted hemp as one of several crops at his Mount Vernon estate. However, hemp's popularity waned in America as other plants used for textiles such as cotton and jute became more widely available. The U.S. Navy briefly campaigned for more hemp farming during World War II to supply ropes for ships. But the federal government continued restrictions on hemp after the war.
A 2015 meta analysis found that, although a longer period of abstinence was associated with smaller magnitudes of impairment, both retrospective and prospective memory were impaired in cannabis users. The authors concluded that some, but not all, of the deficits associated with cannabis use were reversible.[121] A 2012 meta analyses found that deficits in most domains of cognition persisted beyond the acute period of intoxication, but was not evident in studies where subjects were abstinent for more than 25 days.[122] Few high quality studies have been performed on the long-term effects of cannabis on cognition, and results were generally inconsistent.[123] Furthermore, effect sizes of significant findings were generally small.[122] One review concluded that, although most cognitive faculties were unimpaired by cannabis use, residual deficits occurred in executive functions.[124] Impairments in executive functioning are most consistently found in older populations, which may reflect heavier cannabis exposure, or developmental effects associated with adolescent cannabis use.[125] One review found three prospective cohort studies that examined the relationship between self reported cannabis use and intelligence quotient (IQ). The study following the largest number of heavy cannabis users reported that IQ declined between ages 7–13 and age 38. Poorer school performance and increased incidence of leaving school early were both associated with cannabis use, although a causal relationship was not established.[117] Cannabis users demonstrated increased activity in task-related brain regions, consistent with reduced processing efficiency.[126]
Although cannabis as a drug and industrial hemp both derive from the species Cannabis sativa and contain the psychoactive component tetrahydrocannabinol (THC), they are distinct strains with unique phytochemical compositions and uses.[6] Hemp has lower concentrations of THC and higher concentrations of cannabidiol (CBD), which decreases or eliminates its psychoactive effects.[6] The legality of industrial hemp varies widely between countries. Some governments regulate the concentration of THC and permit only hemp that is bred with an especially low THC content.[7][8]
Can cannabis help treat psoriasis? The active cannabinoids in cannabis may be an effective treatment for psoriasis. Research shows that they offer potential health benefits that could relieve the symptoms of psoriasis. They may be able to reduce inflammation and itching, control pain, and even heal wounds. Learn more about cannabis for psoriasis here. Read now
Last year, the National Academies of Sciences, Engineering and Medicine released a nearly 500-page report on the health effects of cannabis and cannabinoids. A committee of 16 experts from a variety of scientific and medical fields analyzed the available evidence — more than 10,000 scientific abstracts in all. Because so few studies examine the effects of CBD on its own, the panel did not issue any findings about CBD specifically, but it did reach some conclusions about cannabis and cannabinoids more generally. The researchers determined that there is “conclusive or substantial evidence” supporting the use of cannabis or cannabinoids for chronic pain in adults, multiple sclerosis-related spasticity (a kind of stiffness and muscle spasms), and chemotherapy-induced nausea and vomiting. The committee also found “moderate” evidence that cannabis or cannabinoids can reduce sleep disturbances in people with obstructive sleep apnea, fibromyalgia, chronic pain and multiple sclerosis, as well as “limited” evidence that these substances can improve symptoms of Tourette’s syndrome, increase appetite and stem weight loss in people with HIV/AIDs, and improve symptoms of PTSD and anxiety.
Cement (Concrete) and Plaster. Utilizing the ancient technique of reinforcing clay with straw to produce reinforced bricks for constructing domiciles, plant fibers have found a number of comparable uses in modern times. Hemp fibers added to concrete increase tensile strength while reducing shrinkage and cracking. Whole houses have been made based on hemp fiber (Fig. 24, 25). In North America, such usage has only reached the level of a cottage industry. Fiber-reinforced cement boards and fiber-reinforced plaster are other occasionally produced experimental products. Hemp fibers are produced at much more cost than wood chips and straw from many other crops, so high-end applications requiring high strength seem most appropriate.
At Hemp Bombs, we’re proud to source our CBD from organic, superior-grade Industrial Hemp that is grown with sustainable methods. Hemp Bombs products contain pure CBD, which is not linked with overdose or addiction. Our CBD products contain zero traces of THC, so they are considered “CBD isolate.” Not only is CBD isolate federally legal, but it also gives you the complete confidence you will not fail a drug test from using CBD products. We manufacture all products in-house. In-house manufacturing means that we maintain complete quality control of products in one facility all the way to packaging and shipping. Hemp Bombs provides you with an apparent breakdown of what is in our CBD. Our products contain pure Cannabidiol and are all labeled with the milligram dosage. Hemp Bombs CBD is third-party lab tested to ensure you the most refined product. The search is over; Hemp Bombs Premium CBD Pain Freeze is your next stop for the ultimate pain and inflammation relief.

It’s also important to select CBD oil products based on your concentration preferences. Some forms of CBD oil – such as vapors and tinctures – normally have higher-than-average concentrations, whereas sprays and topicals tend to have lower concentrations. Remember: higher concentration means more pronounced effects, but not necessarily mean higher quality.

The farm bill is a sprawling piece of legislation that sets U.S. government agricultural and food policy for the country and is renewed roughly every five years. This version of the bill places industrial hemp — which is defined as a cannabis plant with under 0.3% of tetrahydrocannabinol, or THC — under the supervision of the Agriculture Department and removes CBD from the purview of the Controlled Substances Act, which covers marijuana. The law also “explicitly” preserved the Food and Drug Administration’s authority to regulate products containing cannabis, or cannabis-derived compounds.
Ringo’s Gift: This cultivar is named after the cannabidiol pioneer, Lawrence Ringo. Ringo’s Gift is a cross between two other CBD-rich strains, AC/DC and Harle-tsu. Its CBD to THC ratio varies from 1:1 to 22:1, but it consistently favors CBD. Ringo’s Gift smells of earthy pine and promises full-bodied relaxation in tandem with calming cerebral effects which, together, silence pain and anxiety.
Hi Colleen, it's almost a year later and I'm wondering how you're doing. I'm experiencing a recurrence of Stage 3 ovarian, originally diagnosed in 2011. I've decided to get some chemo, not sold on another 6 cycles though. As a new MMJ patient, I'm still going to go through with Rick Simpson Oil (THC+CBD,) and I just joined a program with my local dispensary to get CBD capsules for $2 each when I order them at least 30 at a time. I hope you're doing well!! I'm off to do more research on dosing. **NOTE: If you have ANY experience with CBD treatment of ovarian cancer, PLEASE respond. Thank you!!
Cannabidiol can be taken into the body in multiple ways, including by inhalation of cannabis smoke or vapor, as an aerosol spray into the cheek, and by mouth. It may be supplied as CBD oil containing only CBD as the active ingredient (no added tetrahydrocannabinol [THC] or terpenes), a full-plant CBD-dominant hemp extract oil, capsules, dried cannabis, or as a prescription liquid solution.[2] CBD does not have the same psychoactivity as THC,[9][10] and may affect the actions of THC.[7][8][9][11] Although in vitro studies indicate CBD may interact with different biological targets, including cannabinoid receptors and other neurotransmitter receptors,[9][12]as of 2018 the mechanism of action for its biological effects has not been determined.[8][9]
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