Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.

Despite advanced analytical techniques, much of the cannabis used recreationally is inaccurately classified. One laboratory at the University of British Columbia found that Jamaican Lamb's Bread, claimed to be 100% sativa, was in fact almost 100% indica (the opposite strain).[83] Legalization of cannabis in Canada (as of October 17, 2018) may help spur private-sector research, especially in terms of diversification of strains. It should also improve classification accuracy for cannabis used recreationally. Legalization coupled with Canadian government (Health Canada) oversight of production and labelling will likely result in more—and more accurate—testing to determine exact strains and content. Furthermore, the rise of craft cannabis growers in Canada should ensure quality, experimentation/research, and diversification of strains among private-sector producers.[84]
Most human studies of CBD have been done on people who have seizures, and the FDA recently approved the first CBD-based drug, Epidiolex, for rare forms of epilepsy. Clinical trials for other conditions are promising, but tiny. In one Brazilian study published in 2011 of people with generalized social anxiety disorder, for example, taking a 600-mg dose of CBD (higher than a typical dose from a tincture) lessened discomfort more than a placebo, but only a dozen people were given the pill.

While most supplements have a single recommended dose, CBD is different. The amount of CBD you take depends on your doctor’s recommendations and your own research into how CBD will work for your unique needs. In general, it’s smart to start with a medium dose of CBD. This way, you can increase or decrease the dose as needed. In addition, it’s recommended to start with one half ML (half a dropper) of CBD oil, because you can always take more if needed.
While marijuana cultivation requires ample spacing to reduce the risk of mold or bacteria, hemp can be planted more densely. Most marijuana crops are planted at one (1) plant per four (4) square feet. Hemp plants that are grown for hemp oil are planted at roughly 40 to 60 plants per four (4) square feet. Hemp plants grown for fiber are even more densely planted at a rate of about 100 to 120 plants per four (4) square feet. 

Scientists in Europe and North America concluded that hemp seed is an excellent source of nutrition. Numerous anecdotal incidences cited improvements in a wide range of acute and chronic conditions such as rapid healing of skin lesions and relief from flu, inflammation, and allergies. The benefits were attributed to the presence of rich source of the EFAs linoleic and alpha-linolenic acid, and their respective biologic metabolites, GLA and stearidonic acid.9

A non-intoxicating cannabinoid found in cannabis. After tetrahydrocannabinol (THC), cannabidiol (CBD) is the second-most abundant cannabinoid in the plant, and has many potential therapeutic benefits, including anti-inflammatory, analgesic, anti-anxiety and seizure-suppressant properties. Cannabidiol can be sourced from both marijuana plants and hemp plants, which are legal in most countries as they contain minor amounts of THC.  
With so many companies popping up every day, we’ve done the hard work for you. We bring you the best CBD oil guide and the top 25 brands that made our list based on CBD oil quality, effectiveness, customer service and of course price. Please note, this article is updated constantly, so don’t forget come back from time to time to see the most updated information.
I use this for my anxiety and for my arthritis. The topical works great for my chronic neck pain. The best way to go is to get your own raw, tested material and use it in whatever form you like. It’s quite easy to make your own extract. This has worked better for me, rather than relying on a purchased, untested product – where some seem to work and others are a waste. But even with those that work, of course the cost is ridiculous and not affordable, thanks to all these corporate-pleasing laws in place, not there for the people – don’t delude yourselves. 

In order to manage pain, we recommend ingesting full spectrum CBD oil daily in the form of Tinctures or Gel Capsules. The ingredients in the two products are the same; the only difference between the two is the form factor and dosage – pills vs. sublingual tinctures. We suggest those suffering from any kind of pain start with 5-10mg per day of CBD. If relief is not felt at this dosage, we suggest increasing by 5-10mg until the desired effects are achieved. You’ll notice that the Gel Capsules are pre-filled and contain 25mg of CBD per pill – there is no harm in starting at 25mg CBD daily as you cannot overdose on CBD nor are there any serious side effects. These ingestible products provide sustained relief for several hours – many people find they provide relief for the whole day! The one thing to keep in mind with ingestible CBD products is the delayed onset time – it can take up to 90 minutes for the full effects of the tinctures or capsules to be felt.
The environment is often cited as an important factor influencing the health status of individuals. This includes characteristics of the natural environment, the built environment and the social environment. Factors such as clean water and air, adequate housing, and safe communities and roads all have been found to contribute to good health, especially to the health of infants and children.[18][29] Some studies have shown that a lack of neighborhood recreational spaces including natural environment leads to lower levels of personal satisfaction and higher levels of obesity, linked to lower overall health and well being.[30] This suggests that the positive health benefits of natural space in urban neighborhoods should be taken into account in public policy and land use.
It has been contended that hemp is notably superior to most crops in terms of biomass production, but van der Werf (1994b) noted that the annual dry matter yield of hemp (rarely approaching 20 t/ha) is not exceptional compared to maize, beet, or potato. Nevertheless, hemp has been rated on a variety of criteria as one of the best crops available to produce energy in Europe (Biewinga and van der Bijl 1996). Hemp, especially the hurds, can be burned as is or processed into charcoal, methanol, methane, or gasoline through pyrolysis (destructive distillation). As with maize, hemp can also be used to create ethanol. However, hemp for such biomass purposes is a doubtful venture in North America. Conversion of hemp biomass into fuel or alcohol is impractical on this continent, where there are abundant supplies of wood, and energy can be produced relatively cheaply from a variety of sources. Mallik et al. (1990) studied the possibility of using hemp for “biogas” (i.e. methane) production, and concluded that it was unsuitable for this purpose. Pinfold Consulting (1998) concluded that while there may be some potential for hemp biomass fuel near areas where hemp is cultivated, “a fuel ethanol industry is not expected to develop based on hemp.”
Hemp is possibly one of the earliest plants to be cultivated.[109][110] An archeological site in the Oki Islands near Japan contained cannabis achenes from about 8000 BC, probably signifying use of the plant.[111] Hemp use archaeologically dates back to the Neolithic Age in China, with hemp fiber imprints found on Yangshao culture pottery dating from the 5th millennium BC.[108][112] The Chinese later used hemp to make clothes, shoes, ropes, and an early form of paper.[108] The classical Greek historian Herodotus (ca. 480 BC) reported that the inhabitants of Scythia would often inhale the vapors of hemp-seed smoke, both as ritual and for their own pleasurable recreation.[113]
Though clinical and anecdotal evidence suggests CBD’s benefits in managing different conditions, it became most famous for treating a rare and debilitating form of pediatric epilepsy. Dravet’s Syndrome is notoriously resistant to current approved treatment methods. Sufferers are plagued by seizures, often up to hundreds a day, that worsen as they age and can be life-threatening. Currently, treatment methods include having the child wear an eyepatch, specialized diets, and brain surgery, but all have mixed success rates.
Hemp has very low levels of another cannabis compound, tetrahydrocannabinol (THC) — the main psychoactive compound in marijuana. Evidence suggests that THC — not CBD — causes the symptoms people associate with getting high on marijuana, Blessing says. Unlike marijuana, which the CDC argues is addictive, CBD also doesn’t seem to be, according to the World Health Organization.
The earliest recorded uses date from the 3rd millennium BC.[32] Since the early 20th century, cannabis has been subject to legal restrictions. The possession, use, and sale of cannabis is illegal in most countries of the world.[33][34] Medical cannabis refers to the physician-recommended use of cannabis, which takes place in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 33 U.S. states.[35][36] In September 2018, cannabis was legalized in South Africa[37] while Canada legalized recreational use of cannabis in October 2018.[38]
First, you should not take anything without consulting your physician. While CBD oil is largely safe, a small number of people experience side effects and it could interact with medications you may already be taking like certain antidepressants and antibiotics. Do not be shy about discussing this option, the more open and honest you can be with your doctor, the more they can help you figure out the best path forward if you are considering using CBD oil for pain.

I suffer fr migraines. Currently having Botox injections every three months for the last three years. This has helped went fr 24 to 30 migraines a month to 6 to 8 , now I'm back up to 14 to 20 a month. My doctor thought CBD oil might help. I have also started having anxiety attacks for a year now. I'm really confused with the dosages. Any thoughts would b helpful
Cannabis most likely originates from Central Asia, as archeological evidence indicates that it was already cultivated in China for food and fiber 10 000 years ago. Even in ancient Egyptian mummies, clues have been found for the use of Cannabis as food or medicine.25 In fact, Cannabis is one of the oldest known medicinal plants and is described in almost every ancient handbook on plant medicine, most commonly in the form of a tincture or a tea.26,27 Some religions were closely related with the properties of the Cannabis plant. For example, in Hindu legend, Cannabis is believed to be the favorite food of the god Shiva, because of its energizing properties. As Cannabis spread from Asia toward the West, almost every culture came into contact with this miracle plant. Nowadays, varieties of Cannabis can be found in all temperate and tropical zones, except in humid, tropical rain forests.28

Concrete-like blocks made with hemp and lime have been used as an insulating material for construction. Such blocks are not strong enough to be used for structural elements; they must be supported by a brick, wood, or steel frame.[28] However, hemp fibres are extremely strong and durable, and have been shown to be usable as a replacement for wood for many jobs, including creating very durable and breathable homes. The most common use of hemp lime in building is by casting the hemp and lime mix while wet around a timber frame with temporary shuttering, and tamping the mix to form a firm mass; after the removal of the temporary shuttering, the solidified hemp mix is then ready to be plastered with a lime plaster.[29]
Results of a Phase III study (N = 177) comparing Sativex, THC-predominant extract and placebo in intractable pain due to cancer unresponsive to opiates (Johnson and Potts 2005) demonstrated that Sativex produced highly statistically significant improvements in analgesia (Table 1), while the THC-predominant extract failed to produce statistical demarcation from placebo, suggesting the presence of CBD in the Sativex preparation was crucial to attain significant pain relief.
Dr. Dustin Sulak is the founder and director of Integr8 Health, a network of holistic health clinics specializing in cannabis therapeutics with offices in Maine and Massachusetts. His educational work is featured on Healer.com, a free online patient information resource. This article is adapted from a recent talk given by Dr. Sulak in Portland, Maine, where he discussed the staggering scope of... Read more
The author of a Harvard-led systematic review of 28 studies examining the efficacy of exo-cannabinoids (cannabinoids formed outside of the body, i.e. from the plant or synthetically made) to treat pain and other medical issues concluded, “the use of marijuana for chronic pain, neuropathic pain, and spasticity due to multiple sclerosis is supported by high-quality evidence.”
Cannabis (/ˈkænəbɪs/) is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: Cannabis sativa, Cannabis indica, and Cannabis ruderalis; C. ruderalis may be included within C. sativa; all three may be treated as subspecies of a single species, C. sativa;[1][2][3][4] or C. sativa may be accepted as a single undivided species.[5] The genus is widely accepted as being indigenous to and originating from Central Asia, with some researchers also including upper South Asia in its origin.[6][7]
Public health also takes various actions to limit the health disparities between different areas of the country and, in some cases, the continent or world. One issue is the access of individuals and communities to health care in terms of financial, geographical or socio-cultural constraints to accessing and using services.[54] Applications of the public health system include the areas of maternal and child health, health services administration, emergency response, and prevention and control of infectious and chronic diseases.

"In the past there has been ongoing tension between federal and state authorities over state hemp policies. After North Dakota passed its own state law authorizing industrial hemp production in 1999,62 researchers repeatedly applied for, but did not receive, a DEA permit to cultivate hemp for research purposes in the state.63 Also in 2007, two North Dakota farmers were granted state hemp farming licenses and, in June 2007, filed a lawsuit in U.S. District Court (North Dakota) seeking 'a declaratory judgment' that the CSA 'does not prohibit their cultivation of industrial hemp pursuant to their state licenses.'64 The case was dismissed in November 2007.65 The case was appealed to the U.S. Court of Appeals (Eighth Circuit) but was again dismissed in December 2009.66 The farmers filed an appeal in May 2010.67
What exactly is cannabidiol (CBD) and more importantly, what does it do? Those questions and more are at the heart of this comprehensive guide to one of the most fascinating and important compounds of the cannabis plant. Cannabis plants are chemical powerhouses that produce more than 400 different compounds. Not all of those compounds are unique to marijuana, of course, and appear in many other species of plants. That’s why marijuana can smell like pine trees or taste like fresh lemons. But of those 400 compounds, more than 60 of them are totally specific to the plant genus Cannabis. Scientists call these special compounds “cannabinoids.” However, not all cannabinoids are created equal. One of them, cannabidiol, or CBD, holds the key to the wide variety of medicinal and therapeutic effects marijuana offers.
“What we know is that THC and CBD combined has a greater therapeutic effect than either one given alone,” Lee continued. “The best medicines to use are the medicines that have both THC and CBD. What we suggest to people – and I will emphasize we are not doctors – is that people should use products that have as much THC as possible, with the CBD, that doesn’t make them feel dysphoric or stoned.”
Kent, My mother has suffered from severe migraines since she was a child. Six weeks ago, she received the hemp oil tincture (I do not know what dosage). She does not take it daily. She rubs a drop or two on her temples at the start of a migraine. The drops worked more effectively for her than her medication did, and now that is all she uses. Hope this helps.
The important thing is that you have to be SUPER careful when selecting CBD oils. Since the cannabis industry is not FDA-regulated, there have been dozens and dozens of companies trying to get away with selling very low quality (and even potentially toxic), “snake oils” that have been extracted using harsh chemical solvents like butane and hexane. Make sure you stay away from cheap products like these, as they could damage your health.
Dispensaries are charging 30 bucks and ounce for Hemp Oil so they have no economic incentive to derive the CBD from Marijuana. I found that it was like pulling teeth, just to get the to admit the CBD oil came from Hemp. They isolate the CBD and then add it back to the Oil. This means there is no THC or Terpenes or any of the beneficial compounds found in marijuana.
Cannabis use and psychotic symptoms and disorders are associated in the general population (see, for example, Degenhardt and Hall, 2001; Tien and Anthony, 1990) and in clinical samples of patients with schizophrenia (Mueser et al., 1992; Warner et al., 1994; Hambrecht and Hafner, 1996). The major contending hypotheses to explain the association have been: (i) that cannabis use precipitates schizophrenia in persons who are otherwise vulnerable; (ii) cannabis use is a form of self-medication for schizophrenia; and (iii) that the association arises from uncontrolled residual confounding by variables that predict an increased risk of cannabis use and of schizophrenia (Macleod et al., 2004).
My husband has RSD and we are considering CBD oil -= I would ask at Hempmed because the spray won't have enough in it. Our dgt';s friend has ovarian cancer and it is shrinking her tumors but the spray would never have been enough. I would get CBD oil and check with Hempmeds to see what they suggest. It isn't cheap but it does work. LOW dose Naltrexone about 4.5 mg is very helpful for RSD and is usually used for getting people off of drugs but is working on turning off the glial cells that surround the nerve that is causing the nerve to scream in pain. We are also using PeaPure that is out of the Netherlands and we are seeing a response, even though small. His other leg touched the painful leg without causing more severe pain. That is progress. We also are using Poison Ivy Cream through Meadowlake Farms that has helped the burning surface pain. Change your diet and get rid of Gluten and Sugar, anything that causes inflammation. This is to allow your own body to work. Absolutely do not use any pain killers as it will turn up your pain. all the Hydrocodone, etc causes neural inflammation and so it will keep cascading higher your pain. Hope this is helpful. Mary
"Whereas fibres and shivs did not show any significant difference between 2010 and 2013, the production of seeds increased by 92% and the production of flowers and leaves by 3,000%. The flowers for CBD production gave hemp farmers a considerable extra profit in 2013. It should also be mentioned that hemp is one of the very few crops in Europe that is cultivated on non-organic farms without the use of any agrochemicals. Strong, fast growing hemp crops are able to supress weeds without chemical support and the crop does not suffer from any pests or diseases that would warrant a spray. Hemp also grows well under an organic regime."
Hemp Bombs CBD Pain Freeze is the perfect soothing solution for your pain, cramp, joint and muscle problems. A full dose of CBD is combined with a cold therapy rub to provide the user with long lasting relief. CBD is a well-known pain reliever and anti-inflammatory that is kind to a user's skin. As well as 99% pure CBD, Hemp Bombs Pain Rub is formulated with other natural ingredients like Aloe Vera to enhance the healing potential of the product. At each stage of product development, Hemp Bombs ensures the highest quality CBD from top quality ingredients to conscientious manufacturing practices.

Fresh Nature Hemp is a new manufacturer in CBD industry, but, despite this, Fresh Nature Hemp CBD oil is one of the most efficient product for pain relief on the market. The company works hard to keep standards high, so its CBD products is sourced from organic hemp – no artificial ingredients, pesticides or GMOs. Every batch is tested for safety & efficacy to ensure the purity meets & exceeds industry standards. Unlike many popular manufacturers, Fresh Nature Hemp uses unique CO2 extraction process which provides a near 99% pure CBD oil.
It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
However, because no tools existed for quality control, it was impossible to prepare a standardized medicine, so patients often received a dose that was either too low, having no effect, or too high, resulting in serious side effects. Moreover, Cannabis extract was not water-soluble and therefore could not be injected (in contrast to, e.g., the opiates), whereas oral administration was found to be unreliable because of its slow and erratic absorption. Because of such drawbacks, the medicinal use of Cannabis increasingly disappeared in the beginning of the twentieth century, and in 1937 Cannabis was removed from the US pharmacopoeia, a move that was followed by most other Western countries.27 Isolation and structure elucidation of the first pure active substances from Cannabis was not achieved until the 1960s.29 

At least 38 states considered legislation related to industrial hemp in 2018. These bills ranged from clarifying existing laws to establishing new licensing requirements and programs. At least six states – Alaska, Arizona, Kansas, Missouri, New Jersey and Oklahoma – enacted legislation in 2018 establishing hemp research and industrial hemp pilot programs. Georgia created the House Study Committee on Industrial Hemp Production. States, already allowing for industrial hemp programs, continued to consider policies related to licensure, funding, seed certification, and other issues. For example, Tennessee amended its Commercial Feed Law to include hemp. 


Cannabis is the most widely used illicit drug. Over 100 phytocannabinoids, as well as terpenoids, fatty acids, and other compounds with health relevance, have been found in Cannabis. The pharmacological importance of cannabinoids has been intensively studied. Multiple mechanisms of the effects of cannabinoids on the nervous system are being elucidated. Cannabinoids have anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and anticancer activities. Hemp seed oil and terpenoids have health-promoting effects. The relationship between Cannabis chemotype and genotype is being revealed by chemical and genetic analyses. Various omics platform facilitate the basic and applied studies of Cannabis plants. An expanded Cannabaceae family, which consists of six genera, is advocated. This chapter summarizes the recent research progress of phytochemistry, pharmacology, and omics of Cannabis plants.

A bit of online digging led me to realize that the active ingredient in Charlotte's Web Everyday Plus Hemp Oil, the product I'd been offered to test, was the chemical compound CBD, which stands for Cannabidiol. Unlike THC, the other crucial compound in hemp and marijuana plants, CBD does not produce the psychoactive effects that make you feel "high"; instead, it actually eases anxiety and makes you less likely to freak out. 

In short, the results of the survey (which were published in the Journal of Pain Research) showed that roughly 42% and 46% (respectively) of participants claimed they were able to use cannabis in place of traditional medical to effectively treat their specific medical ailment. So if you’re wondering how to know if you need CBD for pain, remember that you’re certainly not alone.

I use a cbd oil that is 1/1 thc. I had desperately hoped for pain control but while it helped a little while on low dose fentanyl, without I get no relief to speak of. The positive is in its helping my severe digestive issues! I have not been able to eat or digest what I ate for many years and with the use of this oil I am actually gaining weight! I was losing as much as five pounds a week! Just wish it helped with pain control!

Yet Germany’s health insurance companies, doctors, and pharmacies weren’t prepared for the rush. Prior to legalization, cannabis represented a small niche in the country with just a thousands patients with access to the drug because of a special permit. But legalization spawned a rapid growth; in 2018 alone, there were 142,000 prescriptions issued.


CBD research is still in its infancy because both the substance itself and the cultivation of the plants from which it’s derived have long been illegal in the United States. And despite all those cookies you see for sale, CBD does seem to remain illegal, unless FDA approved. In December, hemp cultivation was legalized nationwide as a provision of the Agriculture Improvement Act of 2018. But the FDA released a statement explicating the agency’s stance on CBD’s legality: In short, the FDA does not recognize a distinction between cannabis- and hemp-derived CBD and, for the time being, considers both to be illegal—especially as a questionably safe food additive. Although CBD isn’t dangerous to healthy people, it can affect how the body metabolizes certain types of medication, which Blessing says could lead to overdose in some cases. (Because of the government shutdown, the FDA is unavailable to explain its stance or enforcement plans in further detail.)
Thermal Insulation. Thermal insulation products (Fig. 20, 21) are the third most important sector of the hemp industry of the EU. These are in very high demand because of the alarmingly high costs of heating fuels, ecological concerns about conservation of non-renewable resources, and political-strategic concerns about dependence on current sources of oil. This is a market that is growing very fast, and hemp insulation products are increasing in popularity. In Europe, it has been predicted that tens of thousands of tonnes will be sold by 2005, shared between hemp and flax (Karus et al. 2000).

The genus Cannabis was formerly placed in the nettle (Urticaceae) or mulberry (Moraceae) family, and later, along with the genus Humulus (hops), in a separate family, the hemp family (Cannabaceae sensu stricto).[45] Recent phylogenetic studies based on cpDNA restriction site analysis and gene sequencing strongly suggest that the Cannabaceae sensu stricto arose from within the former family Celtidaceae, and that the two families should be merged to form a single monophyletic family, the Cannabaceae sensu lato.[46][47]
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