Only a handful of countries have legalized recreational marijuana. Uruguay was one of the first, in 2013. The Netherlands is perhaps the country most known for legal marijuana, yet the drug is illegal there. Spain has given its citizens the rights to grow and consume cannabis privately. Peru also allows citizens to possess marijuana as long as it is for personal, private use. As in Costa Rica, where people can have a “small amount,” without legal trouble.

His third question is whether cannabis serves as a gateway drug. There are two possibilities. The first is that marijuana activates certain behavioral and neurological pathways that ease the onset of more serious addictions. The second possibility is that marijuana offers a safer alternative to other drugs: that if you start smoking pot to deal with chronic pain you never graduate to opioids.
"The term ‘“marihuana” means all parts of the plant Cannabis sativa L., whether growing or not; the seeds thereof; the resin extracted from any part of such plant; and every compound, manufacture, salt, derivative, mixture, or preparation of such plant, its seeds or resin. Such term does not include the mature stalks of such plant, fiber produced from such stalks, oil or cake made from the seeds of such plant, any other compound, manufacture, salt, derivative, mixture, or preparation of such mature stalks (except the resin extracted therefrom), fiber, oil, or cake, or the sterilized seed of such plant which is incapable of germination.140
The Food and Drug Administration (FDA) does not consider CBD or products that contain CBD to be dietary supplements. This is because CBD has been studied and approved for use as a new drug to treat epilepsy, which means it is outside the definition of a dietary supplement.5 There may be products available that are marked as dietary supplements, however the amount of cannabidiol they claim to contain may not be accurate.
How do I find CBD oil that contains no THC? I am concerned about failing a drug test but truly need the benefits CBD may provide for pain management. Is it more common in tinctures, vape products, or liquid? Should I be looking for anything specific? There is so much information I feel overwhelmed. How can I trust the sites word that it contains no THC? Any help any of you could provide would be so appreciative!
A clinical endocannabinoid deficiency has been postulated to be operative in certain treatment-resistant conditions (Russo 2004), and has received recent support in findings that anandamide levels are reduced over controls in migraineurs (Sarchielli et al 2006), that a subset of fibromyalgia patients reported significant decreased pain after THC treatment (Schley et al 2006), and the active role of the ECS in intestinal pain and motility in irritable bowel syndrome (Massa and Monory 2006) wherein anecdotal efficacy of cannabinoid treatments have also been claimed. 

“Hemp” refers primarily to Cannabis sativa L. (Cannabaceae), although the term has been applied to dozens of species representing at least 22 genera, often prominent fiber crops. For examples, Manila hemp (abaca) is Musa textilis Née, sisal hemp is Agave sisalina Perrine, and sunn hemp is Crotolaria juncea L. Especially confusing is the phrase “Indian hemp,” which has been used both for narcotic Asian land races of C. sativa (so-called C. indica Lamarck of India) and Apocynum cannabinum L., which was used by North American Indians as a fiber plant. Cannabis sativa is a multi-purpose plant that has been domesticated for bast (phloem) fiber in the stem, a multi-purpose fixed oil in the “seeds” (achenes), and an intoxicating resin secreted by epidermal glands. The common names hemp and marijuana (much less frequently spelled marihuana) have been applied loosely to all three forms, although historically hemp has been used primarily for the fiber cultigen and its fiber preparations, and marijuana for the drug cultigen and its drug preparations. The current hemp industry is making great efforts to point out that “hemp is not marijuana.” Italicized, Cannabis refers to the biological name of the plant (only one species of this genus is commonly recognized, C. sativa L.). Non-italicized, “cannabis” is a generic abstraction, widely used as a noun and adjective, and commonly (often loosely) used both for cannabis plants and/or any or all of the intoxicant preparations made from them.
Content updates feature essential information related to the state’s commercial cannabis regulations and guidelines, the licensing application process, and important announcements from the state’s three cannabis licensing authorities and sister agencies. Links to each state agency’s cannabis information are listed towards the bottom of the home page under the “Collaborating State Agencies” section. 
"Given these data limitations, available trade statistics indicate that the value of U.S. imports under categories actually labeled 'hemp,' such as hemp seeds and fibers—which are more often used as inputs for use in further manufacturing—was nearly $78.2 million in 2015. Compared to 2005, when the value of imports totaled $5.6 million, imported hemp products for use as inputs and ingredients has increased sharply. However, import volumes for other products, such as hemp oil and fabrics, are lower (Table 1). Trade data are not available for finished products, such as hempbased clothing or other products including construction materials, carpets, or paper products.

• What's the dosing? This is a confusing one for many people. "A lot of brands don't do a good job of clearly instructing their consumer on the dosing," says Chris Roth, CEO and co-founder of Highline Wellness. When thinking about dosing, also consider whether your CBD is full-spectrum or isolate: Full-spectrum could include other cannabinoids like cannabidivarin or cannabigerol (this is important, since "there's something called the 'entourage effect' when all together, they're more effective than any one of them alone," Roth explains), while isolate is 100% CBD. "Some people might only need 10 milligrams of full-spectrum CBD, but with isolate, even taking 80 or 100 milligrams might not have the same effect," he says.

In addition to the daily pain management program outlined above, many people find they still need a safe way to manage acute flare ups. Whether it’s caused by a recent injury, cold weather, or general aggravation  – we recommend vaporizing CBD isolate to combat these acute pain flare ups. The benefit of vaporizing or dabbing CBD isolate is that the relief can be felt almost instantaneously. CBD isolate is 99% pure CBD and provides a wave of relief that can be felt throughout the whole body.


Cannabis, a drug prepared from the plant Cannabis sativa (including marijuana, resin, and “skunk”), is used widely throughout the world and is especially popular in North America, Western Europe, West and Central Africa, and Oceania (United Nations Office on Drugs and Crime, 2009). Several studies within the past decade have investigated the effect of continuous use of cannabis on psychotic illnesses, specifically schizophrenia. Zammit, Allebeck, Andreasson, Lundberg, and Lewis (2002) in Sweden found that those who smoked cannabis had a twofold increased risk of developing schizophrenia within 15 years. In addition, the researchers also found a dose–response relationship; subjects who used cannabis more heavily (over 50 reported occasions) were six times as likely to develop schizophrenia compared to those who did not use cannabis at all.
I’ve done a little research on the hemp and cannabis, and it looks to me like they’re both supposed to be medicine plants. From what I learned about the plants, they’ve been known to actually have multiple health benefits and even save lives of fourth stage cancer patients, sending the cancer into remission and therefore saving the patient lives. Banning this medicine plant has actually caused the deaths of many people who could have otherwise been saved by this plant. No wonder people are getting it other ways, I don’t blame them as long as it’s strictly for medical purposes. I even heard of a case where one child’s seizures were so bad they had to end up moving to Colorado as a last resort to save that little girl’s life by giving her cannabis because no other medicine worked for her.

According to Delphic analysis by British researchers in 2007, cannabis has a lower risk factor for dependence compared to both nicotine and alcohol.[98] However, everyday use of cannabis may be correlated with psychological withdrawal symptoms, such as irritability or insomnia,[94] and susceptibility to a panic attack may increase as levels of THC metabolites rise.[99][100] However, cannabis withdrawal symptoms are typically mild and are never life-threatening.[101]


Born in the foothills of the Rocky Mountains, we’ve been growing some of the safest and most thoroughly tested medical cannabis on the market since 2016. Our state-of-the-art facility in Cremona, Alberta, was specifically designed to keep our plants happy, and alongside a meticulous process of harvesting and curing we ensure only the best product arrives at your door.
Focusing more on lifestyle issues and their relationships with functional health, data from the Alameda County Study suggested that people can improve their health via exercise, enough sleep, maintaining a healthy body weight, limiting alcohol use, and avoiding smoking.[27] Health and illness can co-exist, as even people with multiple chronic diseases or terminal illnesses can consider themselves healthy.[28]
All that's changed with the high trade tariffs Trump's levied on countries who import our products. Analysts and existing evidence suggest the soybean trade conflicts will be in favor of fellow exporters, Brazil and Argentina, rather than the U.S. The tariff could drop China’s imports of soybeans by 69% on average. The estimated effect of China’s 25% tariff on U.S. soybean imports would cut income for a midsize Illinois grain farm by an average of 87% over four years, prompting a loss of more than $500,000 in the farm’s net worth by 2021.
I have severe neuropathy in both feet and legs. I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it. I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. Thank you.

Some states only allow for products infused with CBD, some only allow for high-CBD and low-THC products, while others allow both THC and CBD. To further confuse the American citizenry, some states permit patients the use of CBD, but require that they travel to another state to purchase it. To make sense of this confounding patchwork and to learn about each individual state’s CBD laws, read the Weedmaps Laws and Regulations page.
The 2014 Agricultural Act, more commonly known as the 2014 Farm Bill, signed by Democratic President Barack Obama, includes section 7606, which allows for universities and state departments of agriculture to cultivate industrial hemp, as long as it is cultivated for the purpose of research. Under the 2014 Agricultural act, state departments and universities must also be registered with their state, and defer to state laws and regulations for approval to grow hemp.

Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.


© 2019 Floyd's of Leadville. This product is not for use by or sale to persons under the age of 18. This product should be used only as directed on the label. It should not be used if you are pregnant or nursing. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor's advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. Individual weight loss results will vary. By using this site you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited By Law.
CBD edibles are foods and beverages infused with CBD for oral consumption, and they are immensely popular thanks to their delicious taste as well as their soothing effects. From CBD fruit rolls to CBD-infused coffee, CBD edibles include a wide array of shapes, dosages, and mouthwatering flavors. CBD edibles offer an easy and discreet way to never forget your daily dose of CBD. Besides their fun and fruity taste and appearance, Green Roads CBD Edibles offer all the benefits of CBD in a convenient 30-day supply so you’ll never run out whether you need a short-term fix or long-term relief.
The glutamatergic system is integral to development and maintenance of neuropathic pain, and is responsible for generating secondary and tertiary hyperalgesia in migraine and fibromyalgia via NMDA mechanisms (Nicolodi et al 1998). Thus, it is important to note that cannabinoids presynaptically inhibit glutamate release (Shen et al 1996), THC produces 30%–40% reduction in NMDA responses, and THC is a neuroprotective antioxidant (Hampson et al 1998). Additionally, cannabinoids reduce hyperalgesia via inhibition of calcitonin gene-related peptide (Richardson et al 1998a). As for Substance P mechanisms, cannabinoids block capsaicin-induced hyperalgesia (Li et al 1999), and THC will do so at sub-psychoactive doses in experimental animals (Ko and Woods 1999). Among the noteworthy interactions with opiates and the endorphin/enkephalin system, THC has been shown to stimulate beta-endorphin production (Manzanares et al 1998), may allow opiate sparing in clinical application (Cichewicz et al 1999), prevents development of tolerance to and withdrawal from opiates (Cichewicz and Welch 2003), and rekindles opiate analgesia after a prior dosage has worn off (Cichewicz and McCarthy 2003). These are all promising attributes for an adjunctive agent in treatment of clinical chronic pain states.
^ Jump up to: a b Schreiner AM, Dunn ME (October 2012). "Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis". Experimental and Clinical Psychopharmacology. 20 (5): 420–429. doi:10.1037/a0029117. PMID 22731735. Therefore, results indicate evidence for small neurocognitive effects that persist after the period of acute intoxication...As hypothesized, the meta-analysis conducted on studies eval- uating users after at least 25 days of abstention found no residual effects on cognitive performance...These results fail to support the idea that heavy cannabis use may result in long-term, persistent effects on neuropsychological functioning.
It often takes 10 to 15 years for the industry associated with a new agricultural crop to mature. While it is true that foreign imports have been the basis for hemp products in North America for at least a decade, North American production is only 4 years of age in Canada, and farming of hemp in the US has not even begun. Viewed from this perspective, the hemp industry in North America is still very much in its infancy. Varieties of hemp specifically suited to given products and regions have only started to be developed in North America. There is considerable uncertainty regarding yields, costs of production, harvesting and processing equipment, product characteristics, foreign competition, governmental support, and the vagaries of the regulatory environment. Hemp is not presently a standard crop, and is likely to continue experiencing the risks inherent in a small niche market for some time. Hemp is currently a most uncertain crop, but has such a diversity of possible uses, is being promoted by extremely enthusiastic market developers, and attracts so much attention that it is likely to carve out a much larger share of the North American marketplace than its detractors are willing to concede.
This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Tetrahydrocannabinol (THC, Marinol®) and nabilone (Cesamet®) are currently approved in the United States and other countries, but not for pain indications. Other synthetic cannabinoids, such as ajulemic acid, are in development. Crude herbal cannabis remains illegal in most jurisdictions but is also under investigation. Sativex®, a cannabis derived oromucosal spray containing equal proportions of THC (partial CB1 receptor agonist ) and cannabidiol (CBD, a non-euphoriant, anti-inflammatory analgesic with CB1 receptor antagonist and endocannabinoid modulating effects) was approved in Canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain. An Investigational New Drug application to conduct advanced clinical trials for cancer pain was approved by the US FDA in January 2006. Cannabinoid analgesics have generally been well tolerated in clinical trials with acceptable adverse event profiles. Their adjunctive addition to the pharmacological armamentarium for treatment of pain shows great promise.
“We continue to see great progress towards a new perspective on cannabis within the US. Within healthcare, several conditions and certain patient profiles rely heavily on CBD-only products of which the proposed Farm Bill will work to dramatically improve access to patients – not only in the US but globally,” said Prad Sekar, CEO of CB2 Insights in a written interview.
Keep in mind that CBD levels may vary from crop to crop—even from plant to plant. However, below are some strains that have been bred to contain higher CBD levels, so they might be a good place to start. Check the map on their strain page to see if these are sold at a dispensary near you. We also recommend checking with dispensaries about the specifics of their strains’ CBD levels. It’s always a good idea to purchase only lab-tested products that clearly state the CBD/THC levels so you know what kind of experience to expect.
Cannabis played a large role in the Greco-Roman cultures as a source of both fiber, an intoxicant, and a medicine. Cannabis seeds were discovered in the ruins of Pompeii, and Greek rhetorician Athenaeus made note of hemp being used to make rope between 170 and 230 CE. Roman author and naturalist Pliny the Elder also made reference to a cannabis root decoction as a treatment for joint stiffness and gout in the first (1st) century BCE.
According to the U.S. Department of Health and Human Services, 116 people died every-day from opioid-related drug overdoses in 2016. Forty percent of these deaths involved a prescription opioid and in 2017, the government declared the opioid crisis a public health emergency. Opioids are typically prescribed by health care providers as a way to manage and treat pain. But what if there was a better solution?
“What we know is that THC and CBD combined has a greater therapeutic effect than either one given alone,” Lee continued. “The best medicines to use are the medicines that have both THC and CBD. What we suggest to people – and I will emphasize we are not doctors – is that people should use products that have as much THC as possible, with the CBD, that doesn’t make them feel dysphoric or stoned.”

However, given the independent tests published on the official website, the concentration is more than enough for successful and quick pain relief. Also, the extremely low percentage of THC makes the oil safe and legal, as it is not psychoactive. The CBD oil is sold in a few varieties – different sizes, as well as different levels of concentration. The company recommends starting with the lowest dose before moving on. We would recommend this oil for daily use any time.


The first time I came across CBD was when I was visiting my brother in San Antonio, Texas 2 years back. The one day I had some serious back pain, My brother's neighbour suggested that I should try CBD oil for my pain as it helps his mom with her cancer pain, and directed me to SABotanicals, a local CBD store in San Antonio where I bought a 2000mg CBD oil.In the beginning, I was a sceptic, but it worked so well that I ordered three more bottles to last me for a few months. I must say that also felt relaxed but could do my work with no issues as it didn't make me high.To date, I'm still using CBD oil for my paid and came off pain medications completely.God gave us something great!


My daughter was in a car accident and she is in bad pain. She had a stomach hernia from a liver operation & the airbags hurt the hernia. She had the nerves burned on one side of her stomach but it didn’t do any good. Now tomorrow she is having the other side done. her accident was over a month ago. I told her to go to a pain management doctor so she could get help. Then I saw this post & sent it to her. She wants to know if it takes time to work – it so how long. Also would it mix with other meds? Thanks for your response.

Fig. 11. Frequency histograms of THC concentration in germplasm collections. Left, collection of E. Small and D. Marcus; of the 167 accessions, 43% had THC levels >0.3%. Right, the collection of the Vavilov Institute, St. Petersburg; of the 278 accessions for which chemical analyses were reported in Anonymous (1975), about 55% had THC levels >0.3%.
Both in Canada and the US, the most critical problem to be addressed for commercial exploitation of C. sativa is the possible unauthorized drug use of the plant. Indeed, the reason hemp cultivation was made illegal in North America was concern that the hemp crop was a drug menace. The drug potential is, for practical purposes, measured by the presence of THC. THC is the world’s most popular illicit chemical, and indeed the fourth most popular recreational drug, after caffeine, alcohol, and nicotine. “Industrial hemp” is a phrase that has become common to designate hemp used for commercial non-intoxicant purposes. Small and Cronquist (1976) split C. sativa into two subspecies: C. sativa subsp. sativa, with less than 0.3% (dry weight) of THC in the upper (reproductive) part of the plant, and C. sativa subsp. indica (Lam.) E. Small & Cronq. with more than 0.3% THC. This classification has since been adopted in the European Community, Canada, and parts of Australia as a dividing line between cultivars that can be legally cultivated under license and forms that are considered to have too high a drug potential. For a period, 0.3% was also the allowable THC content limit for cultivation of hemp in the Soviet Union. In the US, Drug Enforcement Agency guidelines issued Dec. 7, 1999 expressly allowed products with a THC content of less than 0.3% to enter the US without a license; but subsequently permissible levels have been a source of continuing contention. Marijuana in the illicit market typically has a THC content of 5% to 10% (levels as high as 25% have been reported), and as a point of interest, a current Canadian government experimental medicinal marijuana production contract calls for the production of 6% marijuana. As noted above, a level of about 1% THC is considered the threshold for marijuana to have intoxicating potential, so the 0.3% level is conservative, and some countries (e.g. parts of Australia, Switzerland) have permitted the cultivation of cultivars with higher levels. It should be appreciated that there is considerable variation in THC content in different parts of the plant. THC content increases in the following order: achenes (excluding bracts), roots, large stems, smaller stems, older and larger leaves, younger and smaller leaves, flowers, perigonal bracts covering both the female flowers and fruits. It is well known in the illicit trade how to screen off the more potent fractions of the plant in order to increase THC levels in resultant drug products. Nevertheless, a level of 0.3% THC in the flowering parts of the plant is reflective of material that is too low in intoxicant potential to actually be used practically for illicit production of marijuana or other types of cannabis drugs. Below, the problem of permissible levels of THC in food products made from hempseed is discussed.
In the meantime, some physicians are forging ahead — and cashing in. Joe Cohen is a doctor at Holos Health, a medical marijuana clinic in Boulder. I asked him what CBD is good for, and he read me a long list of conditions: pain, inflammation, nausea, vomiting, intestinal cramping, anxiety, psychosis, muscle spasms, hyperactive immune systems, nervous system degeneration, elevated blood sugar and more. He also claimed that CBD has anti-cancer properties and can regenerate brain cells and reduce the brain’s levels of amyloid beta — a kind of protein that’s been linked to Alzheimer’s disease. I asked for references, noting that most of these weren’t listed in the Academies report or a similar review published in the Journal of the American Medical Association. “I think you just have to Google search it,” he said. It’s true that a preliminary study found hints that cannabinoids might reduce beta amyloid proteins in human brain cells, but the study was done in cells grown in a lab, not in people. As for cancer, the FDA sent warning letters last year to four companies that were selling products that claimed to “prevent, diagnose, treat or cure” cancer.

Overall, Sativex appears to pose less risk of dependency than smoked cannabis based on its slower onset, lower dosage utilized in therapy, almost total absence of intoxication in regular usage, and minimal withdrawal symptomatology even after chronic administration. No known abuse or diversion incidents have been reported with Sativex to date (as of November 2007). Sativex is expected to be placed in Schedule IV of the Misuse of Drugs Act in the United Kingdom once approved.


Feminized cannabis seeds are designed to produce only female plants.Usually, a cannabis seed can develop into a male or female plant; the entire process is determined by the sex expressing X and Y chromosomes. "Feminization" is a process of conditioning female plants to obtain male pollen needed for seed production.A plant with two X chromosomes will be female 99% of the time, while regular cannabis seeds (XY genetic set) sometimes have a tendency to produce more male than female individuals.
A limited number of studies have examined the effects of cannabis smoking on the respiratory system.[89] Chronic heavy marijuana smoking is associated with coughing, production of sputum, wheezing, and other symptoms of chronic bronchitis.[69] The available evidence does not support a causal relationship between cannabis use and chronic obstructive pulmonary disease.[90] Short-term use of cannabis is associated with bronchodilation.[91] Other side effects of cannabis use include cannabinoid hyperemesis syndrome.[92]
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