^ Jump up to: a b c Whiting, PF; Wolff, RF; Deshpande, S; Di Nisio, M; Duffy, S; Hernandez, AV; Keurentjes, JC; Lang, S; Misso, K; Ryder, S; Schmidlkofer, S; Westwood, M; Kleijnen, J (23 June 2015). "Cannabinoids for Medical Use: A Systematic Review and Meta-analysis" (PDF). JAMA. 313 (24): 2456–2473. doi:10.1001/jama.2015.6358. hdl:10757/558499. PMID 26103030.
There is reasonable evidence from prospective epidemiological studies which suggests that cannabis use can precipitate schizophrenia in persons who are vulnerable because of a personal or family history of schizophrenia. There is also evidence that a genetic vulnerability to psychosis increases the risk that cannabis users will develop psychosis (McGuire et al., 1995; Arseneault et al., 2002; Verdoux et al., 2002). A casual relationship also has biological plausibility in that the cannabinoid and dopaminergic neurotransmitter systems interact in animals. D'Souza and colleagues (1999) have shown in a provocation study that THC produces a dose-dependent increase in psychotic symptoms under double-blind placebo conditions; and Caspi and colleagues (2005) have shown an interaction between specific alleles of the COMT allele and psychotogenic effects of cannabis. If these results can be replicated and extended, they will increase the likelihood that cannabis can be a contributory cause of psychosis in vulnerable individuals.
Some users speculate about appropriate dosages or methods of application—including whether or not a small amount of THC boosts CBD’s effects, or whether different methods of administration lead to quicker or more significant effects. Some CBD producers also claim that it has a cumulative effect, and so needs to be used regularly to produce a benefit. But Grant says it’s tough to say at this point exactly how people should (or shouldn’t) be using CBD.
ECS is made up of endocannabinoids and the receptors associated with them. These receptors are literally found from head to toe, and are in such places as the glands, organs, and the brain. While receptors and endocannabinoids are located in all parts of the body, they have different functions depending upon where they are located, with the primary role being to regulate what is referred to as homeostasis or the regulation of the body so that it is at equilibrium.
In this report, researchers reviewed 16 previously published studies testing the use of various cannabis-based medicines in the treatment of chronic neuropathic pain and found some evidence that cannabis-based medicines may help with pain relief and reduce pain intensity, sleep difficulties, and psychological distress. Side effects included sleepiness, dizziness, mental confusion. The authors concluded that the potential harm of such medicines may outweigh their possible benefit, however, it should be noted that the studies used a variety of cannabis-based medicines (e.g. inhaled cannabis and sprays and oral tablets containing THC and/or CBD from plant sources or made synthetically), some of which are more likely to result in these side effects than products without THC.
Can cannabis help treat psoriasis? The active cannabinoids in cannabis may be an effective treatment for psoriasis. Research shows that they offer potential health benefits that could relieve the symptoms of psoriasis. They may be able to reduce inflammation and itching, control pain, and even heal wounds. Learn more about cannabis for psoriasis here. Read now
Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1).
It’s easy to see why vaping has become such a popular method for consuming marijuana. The method is remarkably discrete and produces none of the telltale “weed smells” that often betray cannabis users. Vape pens and other hand-held devices are portable and convenient. They’re free of many of the harsh marijuana plant compounds that can harm your lung health, like tars. And companies are getting better at crafting high-quality, flavorful vape cartridges with a wide array of cannabinoid profiles.
The “re-“growth of industrial hemp in the United States is heavily regulated, although the neighboring nation of Canada successfully grows hemp commercially and on a fairly large scale. Since becoming legal to grow again in Canada, the crop has taken off and has become a booming multi-million dollar export. Hemp derived CBD is very useful for health and the business of producing and selling CBD is thriving. Hemp building materials are another growing segment of the hemp industry. Canada is now a leader in the global hemp food/health marketplace. Canadian hemp products are found in many hemp markets in the United States and many other countries.
Israel, another example, has led the way with ground-breaking research into cannabis cultivation. The country recently recognized medical marijuana as an official part of the nation’s branch of agriculture. Israel is already one of the world’s leading exporters of medical-grade cannabis. Recognizing marijuana cultivation as an official branch of the country’s agriculture will open up even more funds to support Israeli cannabis farmers.
CBD is a 5-HT1A receptor agonist, which may also contribute to an anxiolytic effect. This likely means the high concentrations of CBD found in Cannabis indica mitigate the anxiogenic effect of THC significantly. The cannabis industry claims that sativa strains provide a more stimulating psychoactive high while indica strains are more sedating with a body high. However this is disputed by researchers.
The problem is, it’s not easy to know what you’re actually ingesting, or if it’ll actually change how you feel. At best, CBD in America exists in a confusing state of quasi-legality and yet-to-be-realized potential. Experts estimate that the market for it could balloon to $22 billion by 2022, but with cannabis and hemp laws changing rapidly across the country, the chemical is almost entirely unregulated on the consumer market, with no end-product labeling or composition standards to help shoppers understand what they’re buying.
I recently was a guest at a medical marijuana educational event that highlighted the work of researcher Michael Backes. During his presentation he made a statement about CBD that I have never heard anywhere else that CBD is “regulating” (my word) the effects of THC. I asked the Nurse Practitioner at the event, Ivy Lou Hibbitt of Certicann.com, what he meant by that and she said it was her understanding of Michael’s comment that he takes CBD to reduce the psychoactive effects of THC. Has this property of CBD, that it can lessen psychoactive effects, ever been researched elsewhere?
Public health has been described as "the science and art of preventing disease, prolonging life and promoting health through the organized efforts and informed choices of society, organizations, public and private, communities and individuals." It is concerned with threats to the overall health of a community based on population health analysis. The population in question can be as small as a handful of people or as large as all the inhabitants of several continents (for instance, in the case of a pandemic). Public health has many sub-fields, but typically includes the interdisciplinary categories of epidemiology, biostatistics and health services. Environmental health, community health, behavioral health, and occupational health are also important areas of public health.
The most pressing need of the hemp industry in North America is for the breeding of more productive oilseed cultivars. At present, mainly European cultivars are available, of which very few are suitable for specialized oilseed production. More importantly, hempseed oil is not competitive, except in the novelty niche market, with the popular food oils. As argued above, to be competitive, hemp should produce approximately 2 t/ha; at present 1 t/ha is considered average to good production. Doubling the productive capacity of a conventional crop would normally be considered impossible, but it needs to be understood just how little hemp has been developed as an oilseed. There may not even be extant land races of the kind of hemp oilseed strains that were once grown in Russia, so that except for a very few very recent oilseed cultivars, there has been virtually no breeding of oilseed hemp. Contrarily, hemp has been selected for fiber to the point that some breeders consider its productivity in this respect has already been maximized. Fiber strains have been selected for low seed production, so that most hemp germplasm has certainly not been selected for oilseed characteristics. By contrast, drug varieties have been selected for very high yield of flowers, and accordingly produce very high yield of seeds. Drug varieties have been observed to produce more than a kilogram of seed per plant, so that a target yield of several tonnes per hectare is conceivable (Watson and Clarke 1997). Of course, the high THC in drug cultivars makes these a difficult source of germplasm. However, wild plants of C. sativa have naturally undergone selection for high seed productivity, and are a particularly important potential source of breeding germplasm.
Some manufacturers ship CBD products nationally, an illegal action which the FDA has not enforced in 2018, with CBD remaining the subject of an FDA investigational new drug evaluation, and is not considered legal as a dietary supplement or food ingredient as of December 2018. Federal illegality has made it difficult historically to conduct research on CBD. CBD is openly sold in head shops and health food stores in some states where such sales have not been explicitly legalized.
Receptra offers their products in two separate lines. One is the Active Lifestyle range, which provides lower concentrations for daily use, and another is Health and Wellness, which is for far more intense use. It is incredibly difficult for me to manage my back pain with a low concentration of CBD usually, so, I went with the 3000 mg concentration available in their Health and Wellness line.
Truth be told, one of the biggest draws to using CBD oil for pain has been the fact that it has little distinguishable side-effects or contraindications with other medications. In fact, in a massive report that was published by the World Health Organization during last year’s 2017 Expert Committee on Drug Dependence, it was (finally) declared to the world that CBD is a “safe, well tolerated [compound, which] is not associated with any significant adverse public health effects.”
Scott Shannon, M.D., assistant clinical professor at the University of Colorado, recently sifted through patient charts from his four-doctor practice to document CBD’s effects on anxiety. His study, as yet unpublished, found “a fairly rapid decrease in anxiety scores that appears to persist for months,” he says. But he says he can’t discount a placebo effect, especially since “there’s a lot of hype right now.”
Senate Majority Leader Mitch McConnell continues to be ardently anti-marijuana, despite the success of these programs and the fact that 62% of Americans say recreational marijuana should be legal. Nevertheless, McConnell and Senate Republicans read the political tea leaves and will now recognize the important differences between marijuana and hemp. In doing so, they’re creating an exciting time for entrepreneurs, CBD advocates, and farmers across the country.
Bruce Perlowin, CEO of Hemp, Inc, (OTC: HEMP), believes hemp legalization will drive disenfranchised farmers "back-to-the-land" now that they'll have a solid economic basis in industrial hemp to rely on. "Our strategy has been to partner with farmers across the country in states where hemp cultivation and manufacturing is legal to provide them with the infrastructure needed to make a profit off this incredible crop, and this bill will be an incredible boon for the American small family farm," Perlowin told me. "The health and wellness industries are in for a major overhaul with the massive research and development and exploration into CBD‘s, CBGs, CBN’s and 113 other cannabinoids as well as some 300 terpenes found in the industrial hemp plant."
In the dozen years since e-cigarettes were introduced into the marketplace, they have attracted an enormous amount of attention. There are scores of studies and papers on the subject in the medical and legal literature, grappling with the questions raised by the new technology. Vaping is clearly popular among kids. Is it a gateway to traditional tobacco use? Some public-health experts worry that we’re grooming a younger generation for a lifetime of dangerous addiction. Yet other people see e-cigarettes as a much safer alternative for adult smokers looking to satisfy their nicotine addiction. That’s the British perspective. Last year, a Parliamentary committee recommended cutting taxes on e-cigarettes and allowing vaping in areas where it had previously been banned. Since e-cigarettes are as much as ninety-five per cent less harmful than regular cigarettes, the committee argued, why not promote them? Gottlieb said that he was splitting the difference between the two positions—giving adults “opportunities to transition to non-combustible products,” while upholding the F.D.A.’s “solemn mandate to make nicotine products less accessible and less appealing to children.” He was immediately criticized.
Luke Zigovits, chief executive of Wisconsin-based Hemp Science, said, “We can finally relax. Because now we can source seed, now we can sell our product across state lines. Prohibition is over. It broadens horizons, allowing universities to do research, for example.” Beyond moving the industry into legitimacy, Zigovits said there are opportunities for tobacco farmers in Wisconsin and elsewhere to start growing industrial hemp crops as well.
Generalized pain, for instance, has dozens upon dozens of high profile research and clinical studies that have been carried out in universities and laboratories around the globe. One of the most well-publicized of these studies took place back in 2008, in which results determined that “cannabinoid analgesics (pain relievers) have generally been well tolerated in clinical trials … with acceptable adverse event profiles (meaning acceptable effectiveness for practical use).
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Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop. Some growers in the U.S. succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content. Hemp is classified as any part of the cannabis plant containing (depending on the jurisdiction) no more than 0.2% to 1.0% THC in dry weight form (not liquid or extracted form).[unreliable source?]
Organized interventions to improve health based on the principles and procedures developed through the health sciences are provided by practitioners trained in medicine, nursing, nutrition, pharmacy, social work, psychology, occupational therapy, physical therapy and other health care professions. Clinical practitioners focus mainly on the health of individuals, while public health practitioners consider the overall health of communities and populations. Workplace wellness programs are increasingly adopted by companies for their value in improving the health and well-being of their employees, as are school health services in order to improve the health and well-being of children.
Access to viable seed may present a challenge for research programs and commercial growers. To implement commercial and research hemp programs, farmers need access to seeds that are guaranteed to produce plants that fall under the legal definition of hemp. These seeds can be difficult to obtain, however, because hemp is still regulated under the federal Controlled Substances Act. In response to this problem, Colorado’s governor sent a letter to the U.S. secretary of agriculture in 2014 requesting the federal government address hemp seed regulations.
Opiates are another common pain solution and, unfortunately, they also present a significant number of problems. Opiate medications can be effective at reducing pain symptoms but they are often incredibly strong, causing sedation and a lack of functioning when trying to perform daily activities. A tolerance to opiates can develop over time which means higher and higher doses are required to achieve the same results. Opiates are also very habit forming. It is easy to misuse and overdose on opiates which is one of the reasons that North America is currently in the grip of an opioid crisis, with more than 115 people dying from opiate overdose in the United States every single day.
One of the most experienced practitioners in this field is Los Angeles physician Bonni Goldstein, who has used the compound to treat dozens of children with intractable epilepsy. She says about half of these patients have seen a significant drop in the number of seizures. “Used in the right way, with the right patient, CBD is extremely powerful,” she says.
The 2014 Agricultural Act, more commonly known as the 2014 Farm Bill, signed by Democratic President Barack Obama, includes section 7606, which allows for universities and state departments of agriculture to cultivate industrial hemp, as long as it is cultivated for the purpose of research. Under the 2014 Agricultural act, state departments and universities must also be registered with their state, and defer to state laws and regulations for approval to grow hemp.
Cannabis is the most widely used illicit drug. Over 100 phytocannabinoids, as well as terpenoids, fatty acids, and other compounds with health relevance, have been found in Cannabis. The pharmacological importance of cannabinoids has been intensively studied. Multiple mechanisms of the effects of cannabinoids on the nervous system are being elucidated. Cannabinoids have anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and anticancer activities. Hemp seed oil and terpenoids have health-promoting effects. The relationship between Cannabis chemotype and genotype is being revealed by chemical and genetic analyses. Various omics platform facilitate the basic and applied studies of Cannabis plants. An expanded Cannabaceae family, which consists of six genera, is advocated. This chapter summarizes the recent research progress of phytochemistry, pharmacology, and omics of Cannabis plants.
CBD has powerful effects on the liver as well. Have you ever had a prescription that warns you not to take the medicine along with grapefruit? That’s because grapefruit inhibits certain drug-metabolizing enzymes in your liver, resulting in much higher levels of your medication in your bloodstream. CBD does the same thing, so it is wise to discuss your medication regimen with a doctor or pharmacist before engaging in CBD therapy.
Fig. 5. Typical architecture of categories of cultivated Cannabis sativa. Top left: narcotic plants are generally low, highly branched, and grown well-spaced. Top right: plants grown for oilseed were traditionally well-spaced, and the plants developed medium height and strong branching. Bottom left: fiber cultivars are grown at high density, and are unbranched and very tall. Bottom center: “dual purpose” plants are grown at moderate density, tend to be slightly branched and of medium to tall height. Bottom right: some recent oilseed cultivars are grown at moderate density and are short and relatively unbranched. Degree of branching and height are determined both by the density of the plants and their genetic background.
CBD stands for cannabidiol, one of the major constituents of cannabis. CBD products are made from industrial hemp and come in various forms. Although hemp and cannabis are in the same plant species, CBD products now on the market contain less than 0.3 percent THC (tetrahydrocannabinol), the cannabis compound that gets you high. CBD oil can be mixed into food, either straight or diluted with cooking oil, or it can be heated and its vapors inhaled. You can buy CBD in capsules, liquids, gummies, and sublingual sprays, and it is added to tea, coffee, and smoothies. Business experts estimate that the market for CBD products will reach more than $2 billion in consumer sales in the U.S. within the next four years.
In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex (Blake et al 2006), employed nocturnal treatment only to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD). In the final treatment week, morning pain on movement, morning pain at rest, DAS-28 measure of disease activity, and SF-MPQ pain at present all favored Sativex over placebo (Table 1).
This Farm Bill gives Trump Administration a powerful tool in their bargaining with China. As I wrote earlier this year in Forbes, China produces 50% of the world’s cannabis supply, with a large majority of that supply being the THC-lacking hemp variety; this gives China “massive economic potential” which “poses a threat to cannabis interests around the world and particularly in the U.S. market.”
The etymology is uncertain but there appears to be no common Proto-Indo-European source for the various forms of the word; the Greek term kánnabis is the oldest attested form, which may have been borrowed from an earlier Scythian or Thracian word. Then it appears to have been borrowed into Latin, and separately into Slavic and from there into Baltic, Finnish, and Germanic languages. Following Grimm's law, the "k" would have changed to "h" with the first Germanic sound shift, after which it may have been adapted into the Old English form, hænep. However, this theory assumes that hemp was not widely spread among different societies until after it was already being used as a psychoactive drug, which Adams and Mallory (1997) believe to be unlikely based on archaeological evidence. Barber (1991) however, argued that the spread of the name "kannabis" was due to its historically more recent drug use, starting from the south, around Iran, whereas non-THC varieties of hemp are older and prehistoric. Another possible source of origin is Assyrian qunnabu, which was the name for a source of oil, fiber, and medicine in the 1st millennium BC.
"Hemp bast fibres are among the strongest and most durable of natural fibres, with high tensile strength, wet strength, and other characteristics favourable for various industrial products. It has been estimated that hemp produces three to four times as much useable fibre per acre per year as forests, and the bast fibre contains a low amount of lignin (the natural polymer that binds plant cells together), which allows it to be bleached without the use of chlorine. Hemp bast fibre is used in the production of a wide range of products where its strength and durability are advantageous, including cordage (rope, twine, etc.), specialty papers, fabrics for clothing and other applications, and industrial textiles such as geotextiles and carpeting. The strength of hemp fibre also makes it ideal for use in a range of composites for applications such as moulded car parts and fibreboard for construction."
Air-dried stem yields in Ontario have from 1998 and onward ranged from 2.6–14.0 tonnes of dry, retted stalks per hectare (1–5.5 t/ac) at 12% moisture. Yields in Kent County, have averaged 8.75 t/ha (3.5 t/ac). Northern Ontario crops averaged 6.1 t/ha (2.5 t/ac) in 1998. Statistic for the European Union for 2008 to 2010 say that the average yield of hemp straw has varied between 6.3 and 7.3 ton per ha. Only a part of that is bast fiber. Around one tonne of bast fiber and 2–3 tonnes of core material can be decorticated from 3–4 tonnes of good-quality, dry-retted straw. For an annual yield of this level is it in Ontario recommended to add nitrogen (N):70–110 kg/ha, phosphate (P2O5): up to 80 kg/ha and potash (K2O): 40–90 kg/ha. The average yield of dry hemp stalks in Europe was 6 ton/ha (2.4 ton/ac) in 2001 and 2002.
A 2015 meta analysis found that, although a longer period of abstinence was associated with smaller magnitudes of impairment, both retrospective and prospective memory were impaired in cannabis users. The authors concluded that some, but not all, of the deficits associated with cannabis use were reversible. A 2012 meta analyses found that deficits in most domains of cognition persisted beyond the acute period of intoxication, but was not evident in studies where subjects were abstinent for more than 25 days. Few high quality studies have been performed on the long-term effects of cannabis on cognition, and results were generally inconsistent. Furthermore, effect sizes of significant findings were generally small. One review concluded that, although most cognitive faculties were unimpaired by cannabis use, residual deficits occurred in executive functions. Impairments in executive functioning are most consistently found in older populations, which may reflect heavier cannabis exposure, or developmental effects associated with adolescent cannabis use. One review found three prospective cohort studies that examined the relationship between self reported cannabis use and intelligence quotient (IQ). The study following the largest number of heavy cannabis users reported that IQ declined between ages 7–13 and age 38. Poorer school performance and increased incidence of leaving school early were both associated with cannabis use, although a causal relationship was not established. Cannabis users demonstrated increased activity in task-related brain regions, consistent with reduced processing efficiency.
One of the most curious uses of hemp is as a fence to prevent pollen transfer in commercial production of seeds. Isolation distances for ensuring that seeds produced are pure are considerable for many plants, and often impractical. At one point in the 1980s, the only permitted use of hemp in Germany was as a fence or hedge to prevent plots of beets being used for seed production from being contaminated by pollen from ruderal beets. The high and rather inpenetrable hedge that hemp can produce was considered unsurpassed by any other species for the purpose. As well, the sticky leaves of hemp were thought to trap pollen. However, Saeglitz et al. (2000) demonstrated that the spread of beet pollen is not effectively prevented by hemp hedges. Fiber (i.e. tall) cultivars of hemp were also once used in Europe as wind-breaks, protecting vulnerable crops against wind damage. Although hemp plants can lodge, on the whole very tall hemp is remarkably resistant against wind.
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The 2018 Farm Bill will radically overhaul America’s relation to hemp and could unleash a hemp renaissance in the coming years that will close the gap between the U.S. and China. As a Schedule 1 substance alongside marijuana, hemp farmers and entrepreneurs in the U.S. have faced many barriers to doing business. Interstate commerce for hemp products was almost non-existent and financing was difficult to come by. But all that is set to change.
"Hemp fields, in fact, could be a deterrent to marijuana growers. A strong case can be made that the best way to reduce the THC level of marijuana grown outdoors would be to grow industrial hemp near it. An experiment in Russia found that hemp pollen could travel 12 kilometers. This would mean that a hemp field would create a zone with a 12-kilometer radius within which no marijuana grower would want to establish a crop.
^ Jump up to: a b Deitch, Robert (2003). Hemp: American History Revisited: The Plant with a Divided History. Algora Publishing. pp. 4–26. ISBN 9780875862262. Retrieved 2013-11-16. Cannabis is ... a plant that played an important role in colonial America's prosperous economy and remained a valuable commercial commodity up until the Second World War.
Cohen has found that chronic conditions including autoimmune diseases and pain syndromes can be helped with a 6-mg under-the-tongue tincture (the fastest delivery system) or a 25-mg capsule taken twice a day. Dosages for topical products like lotions are especially hard to determine—there’s no clarity on how much CBD gets into the system through the skin.
"In response to DEA actions to block seeds imported by some states in order to grow industrial hemp and to avoid future similar DEA actions to stall full implementation of the hemp provision of the farm bill, Congress acted swiftly. Both the House and Senate FY2015 Commerce-JusticeScience (CJS) appropriations bills contained provisions to block federal law enforcement authorities from interfering with state agencies and hemp growers and counter efforts to obstruct agricultural research. The enacted FY2015 appropriation blocked federal law enforcement authorities from interfering with state agencies, hemp growers, and agricultural research.46 The provision stated that 'none of the funds made available' to the U.S. Justice Department and DEA 'may be used in contravention' of the 2014 farm bill.
The pulp and paper industry based on wood has considered the use of hemp for pulp, but only on an experimental basis. Hemp’s long fibers could make paper more recyclable. Since virgin pulp is required for added strength in the recycling of paper, hemp pulp would allow for at least twice as many cycles as wood pulp. However, various analyses have concluded that the use of hemp for conventional paper pulp is not profitable (Fertig 1996).
Male hemp plants flower much faster than females and do not produce nearly as much fiber. In stark contrast to marijuana fields, most female hemp fields include sporadically placed males. The male hemp plants release pollen for the female hemp plant to produce seeds that will either be used for future crops or sold as food. In marijuana fields, males are typically eliminated to ensure the maximum production of sensimilla flowers.
Right now, due to arcane laws that are about to change around the world, and strange licensing procedures, cannabis is a supply issue, but that will all change over time. Cannabis is a plant that can grow in 12 weeks, 16 weeks for some Indica strains. There will never be a shortage or issue with getting cannabis when it is a plant that can be produced anywhere in the world, in large batches, every 12 weeks.
Cannabis consumers have long prized potency (a high THC content) as one of the main factors that makes a particular strain more desirable. Though traditional demand for THC has caused an oversaturation of high-potency products, many consumers are starting to prefer less intense products that are lower in THC and higher in the non-intoxicating compound called cannabidiol (CBD).