Cannabis for industrial uses is valuable in tens of thousands of commercial products, especially as fibre[107] ranging from paper, cordage, construction material and textiles in general, to clothing. Hemp is stronger and longer-lasting than cotton. It also is a useful source of foodstuffs (hemp milk, hemp seed, hemp oil) and biofuels. Hemp has been used by many civilizations, from China to Europe (and later North America) during the last 12,000 years.[107][108] In modern times novel applications and improvements have been explored with modest commercial success.[109][110]
In November 2015, Uttarakhand became the first state of India to legalize the cultivation of hemp for industrial purposes.[235] Usage within the Hindu and Buddhist cultures of the Indian subcontinent is common, with many street vendors in India openly selling products infused with cannabis, and traditional medical practitioners in Sri Lanka selling products infused with cannabis for recreational purposes and well as for religious celebrations.[236] It was criminalized in the Indian subcontinent by the Dutch and then the British. India and Sri Lanka have allowed cannabis to be taken in the context of traditional culture for recreational/celebratory purposes and also for medicinal purposes.[236]
Hi Lauren I've just started today with 250mg cbd oil. I'm starting low to see what happens. I've nerve damage across buttocks from a laminectomy. I've not been able to sit for 5 years. I've recently started with a muscle spasm in my left buttock and the muscle above is painful. It is only the first day, also tried a cbd night time tea as well. Do change in muscle pain so tight on my left hand side. How long before felt it starting to work please. I'm trying not to expect changes straightaway. I also take 1100mg gabapentin and 30mg amitriptyline and I hate both of them - they both can cause muscle tightness affecting the nerve. Thank you Lyn

When I first learned about CBD oil, I'll admit I was a bit skeptical. My mind immediately turned to weed and the unnerving experiences I'd had with heightened anxiety in college. For me, a person who's already predisposed to overthinking, marijuana, no matter what the form, would typically put my mind into overdrive and result in a common yet dreaded side effect: paranoia.


Cannabis is used in three main forms: marijuana, hashish and hash oil. Marijuana is made from dried flowers and leaves of the cannabis plant. It is the least potent of all the cannabis products and is usually smoked or made into edible products like cookies or brownies (see Factsheet: Marijuana Edibles). Hashish is made from the resin (a secreted gum) of the cannabis plant. It is dried and pressed into small blocks and smoked. It can also be added to food and eaten. Hash oil, the most potent cannabis product, is a thick oil obtained from hashish. It is also smoked.
Senate Majority Leader Mitch McConnell continues to be ardently anti-marijuana, despite the success of these programs and the fact that 62% of Americans say recreational marijuana should be legal. Nevertheless, McConnell and Senate Republicans read the political tea leaves and will now recognize the important differences between marijuana and hemp. In doing so, they’re creating an exciting time for entrepreneurs, CBD advocates, and farmers across the country.
Health, as defined by the World Health Organization (WHO), is "a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity."[1][2] This definition has been subject to controversy, as it may have limited value for implementation.[3][4][5] Health may be defined as the ability to adapt and manage physical, mental and social challenges throughout life.[6]
Industrial hemp contains, by weight, far less CBD than CBD-rich cultivars such as Harlequin or Sour Tsunami. This means that producing a single 10 mL dose of CBD would require the cultivation and extraction of far more hemp than it would from whole-plant marijuana; thus raising the risk of exposing users to more contaminants. Hemp is classified as a “bioaccumulator,” or a plant that naturally absorbs toxicants from the soil.
American Shaman CBD oil capsules is potent and speedy in relieving pain. It is among the strongest CBD products on the market due to the high concentrations of CBD. In terms of concentration, it is one of the front runners. The manufacturer is not new at all, so it does not belong to this modern trend of CBD , but its products dominate the market for years. Overtime, it has developed a solid reputation based on quality.
During the period from 1937 to the late 60s, the U.S. government understood and acknowledged that industrial hemp and marijuana were distinct varieties of the Cannabis plant. Hemp was no longer officially recognized as distinct from marijuana after the passage of the Controlled Substances Act (CSA) of 1970. This is despite the fact that a specific exemption for hemp was included in the CSA under the definition of marijuana. The recent federal court case HIA vs DEA has re-established acknowledgement of distinct varieties of Cannabis, and supports the exemption for non-viable seed and fiber and any products made from them.
Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can however say that CBD is a natural anti-inflammatory and could assist. I can also share our top selling products in each category. Please view the links below:http://cbdoilreview.org/product/elixinol-cbd-oil-extract-x-pen-1000mg/http://cbdoilreview.org/product/endoca-hemp-oil-drops-1500mg/http://cbdoilreview.org/product/elixinol-hemp-oil-drops-regular-300mg/http://cbdoilreview.org/product/elixinol-cbd-hemp-oil-capsules-900mg/https://cbdoilreview.org/product/vape-bright-starter-pack-200-mg/This is also a great link to some pages that you may find helpful https://cbdoilreview.org/cbd-cannabidiol/

As noted above, hemp seed cake makes an excellent feed for animals. However, feeding entire plants is another matter, because the leaves are covered with the resin-producing glands. While deer, groundhogs, rabbits, and other mammals will nibble on hemp plants, mammals generally do not choose to eat hemp. Jain and Arora (1988) fed narcotic Cannabis refuse to cattle, and found that the animals “suffered variable degrees of depression and revealed incoordination in movement.” By contrast, Letniak et al. (2000) conducted an experimental trial of hemp as silage. No significant differences were found between yield of the hemp and of barley/oat silage fed to heifers, suggesting that fermenting hemp plants reduces possible harmful constituents.


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"In 1943, U.S. hemp production reached more than 150 million pounds (140.7 million pounds hemp fiber; 10.7 million pound hemp seed) on 146,200 harvested acres. This compared to prewar production levels of about 1 million pounds. After reaching a peak in 1943, production started to decline. By 1948, production had dropped back to 3 million pounds on 2,800 harvested acres, with no recorded production after the late 1950s.38"
Though clinical and anecdotal evidence suggests CBD’s benefits in managing different conditions, it became most famous for treating a rare and debilitating form of pediatric epilepsy. Dravet’s Syndrome is notoriously resistant to current approved treatment methods. Sufferers are plagued by seizures, often up to hundreds a day, that worsen as they age and can be life-threatening. Currently, treatment methods include having the child wear an eyepatch, specialized diets, and brain surgery, but all have mixed success rates.

Elixinol has a wide range of products, but their CBD Tincture does the trick. It’s the cream of the crop regarding CBD oils and that reflects in its price. One dropper (1mg) from the 300 series contains 10mg of CBD. This allows you to get precise amounts of CBD and no guess work is required. Elixinol has received numerous awards for their products and extraction process.
I have severe neuropathy in both feet and legs. I just got the CBD oil and I am interested in learning if anyone out there has had any success with this. I know each case and pain levels are different. Just would like to see some positive remarks from people who suffer with it. I am not looking for a cure just need an update on someone who took and it helped. I already know there is no cure. I need help with the pain. Thank you.
Fiberboard. In North America the use of nonwood fibers in sheet fiberboard (“pressboard” or “composite board”) products is relatively undeveloped. Flax, jute, kenaf, hemp, and wheat straw can be used to make composite board. Wheat straw is the dominant nonwood fiber in such applications. Although it might seem that hemp bast fibers are desirable in composite wood products because of their length and strength, in fact the short fibers of the hurds have been found to produce a superior product (K. Domier, pers. commun.). Experimental production of hemp fiberboard has produced extremely strong material (Fig. 22). The economic viability of such remains to be tested. Molded fiberboard products are commercially viable in Europe (Fig. 23), but their potential in North America remains to be determined.

I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you
CBD has been touted for a wide variety of health issues, but the strongest scientific evidence is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications. In numerous studies, CBD was able to reduce the number of seizures, and in some cases it was able to stop them altogether. Videos of the effects of CBD on these children and their seizures are readily available on the Internet for viewing, and they are quite striking. Recently the FDA approved the first ever cannabis-derived medicine for these conditions, Epidiolex, which contains CBD.
Whether the chronic pain is in your back, neck, hands, feet, or elsewhere – CBD can help! In order to understand how CBD helps provide pain relief, we turn to a series of medical studies that have been conducted over the past ten years. These studies evaluated CBD’s medical efficacy in treating those who suffer from various types of pain. We will address the results below.
“It probably should be called snake oil,” says Tishler. (So...save your cash.) Not only does hemp oil not have any real health benefits, but it may contain stuff that's actually bad for you. "At the moment what you can buy is less regulated than the potato at the supermarket," says Tishler. When hemp oil is extracted, there's a risk that pesticides, plastics, and heavy metals could make their way in, says Tishler.

The dosages mentioned do not take into account the strength of the tincture. I have Elixinol 300, I took 1/2 dropper (0.5ml, which offers 5mg of CBD) as indicated on the bottle and felt severely nauseous for 3 hours thereafter. There is no way I cold take this dose twice per day, as recommended on the bottle. The high dosages on this site must surely be for much weaker concentrations?
"Hemp was widely grown in the United States from the colonial period into the mid-1800s. Fine and coarse fabrics, twine, and paper from hemp were in common use. By the 1890s, labor-saving machinery for harvesting cotton made the latter more competitive as a source of fabric for clothing, and the demand for coarse natural fibers was met increasingly by imports. Industrial hemp was handled in the same way as any other farm commodity in that USDA compiled statistics and published crop reports33 and provided assistance to farmers promoting production and distribution.34 In the early 1900s, hemp continued to be grown, and USDA researchers continued to publish information related to hemp production and also reported on hemp’s potential for use in textiles and in paper manufacturing.35 Several hemp advocacy groups, including HIA and Vote Hemp, Inc., have compiled other historical information and have copies of original source documents.36
Some immediate undesired side effects include a decrease in short-term memory, dry mouth, impaired motor skills and reddening of the eyes.[50] Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory,[51][52] psychomotor coordination, and concentration.
I have sporadic back spasms for year I see a chiropractor monthly for maintenance (it help) and deal with daily Knee & hip joint pain due to my job (heavy mechanic/steel work with lots of walking). after reading all the great reviews on CBD oil I want to get off the daily ibuprofen regiment and try CBD oil. I would like to try it as a gel cap but would like some advise on dosage size. I also want to know how often I should take the CBD treatments. any and all advise is appreciated
Locsta....I share your pain of degenerative and bulging disk disease, along with fibromyalgia, chronic fatigue and arthritis. Absolutely no energy and chronic pain all day, every day. I'm curious as to what type and brand of the CBD oil you are taking and for how long have you been using it? I've been researching CBD oil for months and am quite confused!
A rather thorough analysis of the scope of the illicit marijuana industry in Canada for 1998 is reported at www.rcmp-grc.gc.ca/html/drugsituation.htm#Marihuana and summarized in MacLeod (1999). At least 800 tonnes (t) of marijuana were grown in Canada in 1998, representing a harvest of 4.7 million flowering plants. More than 50% of the marijuana available in Canada is grown domestically. An average mature plant was estimated to produce 170 g of “marketable substance.” The value of the Canadian crop is uncertain, but has been estimated to be in the billions of dollars annually (Heading 1998; MacLeod 1999).
CBD has some other very important jobs outside of the endocannabinoid system (ECS). For instance, CBD mildly activates one of the brain’s predominant serotonin receptors (5-HT1A), which may explain CBD’s effects on depression and anxiety. It also acts at the peroxisome proliferator activated receptors (PPARs), which halt the proliferation of cancer cells and convey neuro- and cardioprotection. By interacting with a particular PPAR (gamma), CBD could prove to be a promising new way to prevent alzheimer’s disease and other brain disorders.
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Hi, I am new to trying CBD oil for chronic pain. I really do not know where to begin . For 14 yrs now I have been living with chronic back pain. I have had surgery, numerous shots, etc. I have been on pain ( opiods) for 14 yrs. I am looking to find something not only for my pain, depression, not sleeping ,anxiety, etc. I know that most my problems come from my chronic pain and being on pain meds for so long. Can anyone please recommend a CBD oil product and strength for me. I have been reading all the reviews and I just need someone to help. I have talked to my Doctor about it and he feels that I should try, but didn’t recommend what. 

Hemp has at times in the past been grown simply for its ornamental value. The short, strongly-branched cultivar ‘Panorama’ (Fig. 43) bred by Iván Bósca, the dean of the world’s living hemp breeders, was commercialized in Hungary in the 1980s, and has been said to be the only ornamental hemp cultivar available. It has had limited success, of course, because there are very few circumstances that permit private gardeners can grow Cannabis as an ornamental today. By contrast, beautiful ornamental cultivars of opium poppy are widely cultivated in home gardens across North America, despite their absolute illegality and the potentially draconian penalties that could be imposed. Doubtless in the unlikely event that it became possible, many would grow hemp as an ornamental.
Cannabis has psychoactive and physiological effects when consumed.[45] The immediate desired effects from consuming cannabis include relaxation and euphoria (the "high" or "stoned" feeling), a general alteration of conscious perception, increased awareness of sensation, increased libido[46] and distortions in the perception of time and space. At higher doses, effects can include altered body image, auditory and/or visual illusions, pseudohallucinations and ataxia from selective impairment of polysynaptic reflexes. In some cases, cannabis can lead to dissociative states such as depersonalization[47][48] and derealization.[49]
Hemp hasn't always been on the wrong side of the authorities. The Puritans brought hemp with them to New England in 1645 and Europeans were growing it even earlier in Chile. George Washington planted hemp as one of several crops at his Mount Vernon estate. However, hemp's popularity waned in America as other plants used for textiles such as cotton and jute became more widely available. The U.S. Navy briefly campaigned for more hemp farming during World War II to supply ropes for ships. But the federal government continued restrictions on hemp after the war.

The Medical Marijuana Industry here has glommed on to the “Alternative” Medicine Industry models. I half expected the Dispensary employee to explain that because the Hemp Oil was in contact with CBD, it was the same thing. The Industry even has high quality magazines where they advertise and give advice, most contain a lot of pseudo science. The refer to Pharma Industry Studies as proof that CBD works.


The term hemp is used to name the durable soft fiber from the Cannabis plant stem (stalk). Cannabis sativa cultivars are used for fibers due to their long stems; Sativa varieties may grow more than six metres tall. However, hemp can refer to any industrial or foodstuff product that is not intended for use as a drug. Many countries regulate limits for psychoactive compound (THC) concentrations in products labeled as hemp.
Only since the flower-power-time of the 1960s, the smoking of Cannabis as a recreational drug has become a widely known phenomenon in the Western world. From then on, import of stronger varieties from the tropics, combined with a growing expertise in breeding and cultivation, led to a steady increase in psychoactive potency. Contemporary recreational Cannabis has increasingly become a high-tech crop, grown indoors under completely artificial conditions.
The Marinol patient monograph cautions that patients should not drive, operate machinery or engage in hazardous activities until accustomed to the drug’s effects (http://www.solvaypharmaceuticals-us.com/static/wma/pdf/1/3/1/9/Marinol5000124ERev52003.pdf). The Sativex product monograph in Canada (http://www.bayerhealth.ca/display.cfm?Object_ID=272&Article_ID=121&expandMenu_ID=53&prevSubItem=5_52) suggests that patients taking it should not drive automobiles. Given that THC is the most active component affecting such abilities, and the low serum levels produced in Sativex therapy (vide supra), it would be logical that that patients may be able to safely engage in such activities after early dose titration and according to individual circumstances, much as suggested for oral dronabinol. This is particularly the case in view of a report by an expert panel (Grotenhermen et al 2005) that comprehensively analyzed cannabinoids and driving. It suggested scientific standards such as roadside sobriety tests, and THC serum levels of 7–10 ng/mL or less, as reasonable approaches to determine relative impairment. No studies have demonstrated significant problems in relation to cannabis affecting driving skills at plasma levels below 5 ng/mL of THC. Prior studies document that 4 rapid oromucosal sprays of Sativex (greater than the average single dose employed in therapy) produced serum levels well below this threshold (Russo 2006b). Sativex is now well established as a cannabinoid agent with minimal psychotropic effect.
In the United States, the public's perception of hemp as marijuana has blocked hemp from becoming a useful crop and product,"[55] in spite of its vital importance prior to World War II.[56] Ideally, according to Britain's Department for Environment, Food and Rural Affairs, the herb should be desiccated and harvested towards the end of flowering. This early cropping reduces the seed yield but improves the fiber yield and quality.[57] In these strains of industrial hemp* the tetrahydrocannabinol (THC) content would have been very low.[55]
As noted in the previous section, CBD oil prices vary significantly by brand. The best practice for most is to determine a per-milligram budget for CBD oil, as well as a maximum price for the entire bottle. For example, you might decide that 10 cents per milligram or less is a reasonable budget; and that $45 (for a 450-mg concentration, based on the budget) is a maximum bottle price. Also, if ordering online, be sure to include potential shipping costs.
I have a brother in law who has been diagnosed with cataplexy and narcoplexy, where he starts quivering and slowly loses control of his body and goes into a sleep, which causes him to drop to the ground with mild seizures while he is out. He lives alone (59 years old), but has smoked cannabis since he (we) were teenagers. He still smokes, and is on medication twice a day for this condition, but if he misses those meds by even half an hour, he is at risk of these seizures. The sad part is, these seizures are usually brought on by the smallest emotional change, usually tension, excitement or, the worst thing, if something he finds funny and is the least bit tickled about and starts to laugh, this process will immediately begin. Does anyone know if this kind of condition is treatable with cbd oil’s or concentrates? As I said, he smokes weed, and often grows his own, but he does it for the high and relaxation advantage, since he is basically home-bound due to this condition ending his work career about 4 years ago. Thanks for any replies. I’d be overjoyed if I could tell him there’s a possible solution to the problem other than his prescriptions. Or even if it worked WITH his meds to keep from having to live such a sedentary life.
People are turning to CBD oil to treat their pain more and more. Whether acute to chronic, pain can be located in different areas of the body and may be experienced at different intensities. This wide range of pain complaints among individual may call for different types of treatment that are more comprehensive than just swallowing a general prescription pill. The good news is that CBD can be applied topically or consumed orally. Furthermore, CBD can be taken sublingually, smoked, eaten, or even vaporized, depending on the product. In this way, CBD can treat pain very specifically rather than generally, because let’s face it, one size does not fit all.
There are also other difficulties in researching the effects of cannabis. Many people who smoke cannabis also smoke tobacco.[277] This causes confounding factors, where questions arise as to whether the tobacco, the cannabis, or both that have caused a cancer. Another difficulty researchers have is in recruiting people who smoke cannabis into studies. Because cannabis is an illegal drug in many countries, people may be reluctant to take part in research, and if they do agree to take part, they may not say how much cannabis they actually smoke.[278]
In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex (Blake et al 2006), employed nocturnal treatment only to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD). In the final treatment week, morning pain on movement, morning pain at rest, DAS-28 measure of disease activity, and SF-MPQ pain at present all favored Sativex over placebo (Table 1).
Bruce Perlowin, CEO of Hemp, Inc, (OTC: HEMP), believes hemp legalization will drive disenfranchised farmers "back-to-the-land" now that they'll have a solid economic basis in industrial hemp to rely on. "Our strategy has been to partner with farmers across the country in states where hemp cultivation and manufacturing is legal to provide them with the infrastructure needed to make a profit off this incredible crop, and this bill will be an incredible boon for the American small family farm," Perlowin told me. "The health and wellness industries are in for a major overhaul with the massive research and development and exploration into CBD‘s, CBGs, CBN’s and 113 other cannabinoids as well as some 300 terpenes found in the industrial hemp plant."
President Donald Trump signed the 2018 farm bill on Thursday afternoon, which legalized hemp — a variety of cannabis that does not produce the psychoactive component of marijuana — paving the way to legitimacy for an agricultural sector that has been operating on the fringe of the law. Industrial hemp has made investors and executives swoon because of the potential multibillion-dollar market for cannabidiol, or CBD, a non-psychoactive compound that has started to turn up in beverages, health products and pet snacks, among other products.
This article will attempt to present information concerning cannabinoid mechanisms of analgesia, review randomized clinical trials (RCTs) of available and emerging cannabinoid agents, and address the many thorny issues that have arisen with clinical usage of herbal cannabis itself (“medical marijuana”). An effort will be made to place the issues in context and suggest rational approaches that may mitigate concerns and indicate how standardized pharmaceutical cannabinoids may offer a welcome addition to the pharmacotherapeutic armamentarium in chronic pain treatment.
An increasing number of studies and reports from different organizations and contexts examine the linkages between health and different factors, including lifestyles, environments, health care organization and health policy, one specific health policy brought into many countries in recent years was the introduction of the sugar tax. Beverage taxes came into light with increasing concerns about obesity, particularly among youth. Sugar-sweetened beverages have become a target of anti-obesity initiatives with increasing evidence of their link to obesity.[21]– such as the 1974 Lalonde report from Canada;[20] the Alameda County Study in California;[22] and the series of World Health Reports of the World Health Organization, which focuses on global health issues including access to health care and improving public health outcomes, especially in developing countries.[23]
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More recently, Sakamoto and various co-authors[35][36] have used RAPD to isolate several genetic marker sequences that they name Male-Associated DNA in Cannabis (MADC), and which they interpret as indirect evidence of a male chromosome. Several other research groups have reported identification of male-associated markers using RAPD and AFLP.[37][25][38] Ainsworth commented on these findings, stating,
There are hundreds of compounds in marijuana, but scientists believe the one responsible for the drugs' psychoactive effects is tetrahydrocannbinol, or THC. THC binds to cannabinoid receptors throughout the body, and marijuana's "high" comes from THC's binding to brain regions responsible for pleasure, time perception and pain, according to the National Institute on Drug Abuse (NIDA). 
I can’t disagree more with attacking “Big Pharma” or Trump with regards to fixing this problem! Screw the political affiliations for now, let’s change the whole Schedule 1 nightmare. We’re steeped in technology and we have insanely archaic drug laws. Worse, our gov then pressures the countries we give money to (which is all of them) to follow suit by adopting our effed up way. Schedule 1 needs to be dismantled. The research can’t be done on anything listed with very few exceptions. There’s other Sched.1 drugs that need to be available for research by legitimate people, there’s lots of exciting research in psychedelics that’s stalled by archaic laws. That part might just require big pharma to help.
Moreover, a patient survey conducted by Project CBD, declared that “…cannabis appears to be an effective pain management tool with few negative side effects.” The study went on to say that a “…significant decrease in opiate usage among elderly patients while taking medical cannabis [was observed during trial].” In short, it has been portrayed clearly numerous times through valid and well-publicized clinical studies that cannabis is a practical option in terms of efficient pain management.
Even those who are facing issues related to mental health should consult their physician. Research studies continue to examine the effects and benefits of this drug far beyond just anxiety and depression. The benefits for those facing schizophrenia may be just the tip of the iceberg, as this may help with such conditions as mania and other forms of psychosis with further research.
In September 2005, New Scientist reported that researchers at the Canberra Institute of Technology had identified a new type of Cannabis based on analysis of mitochondrial and chloroplast DNA.[81] The New Scientist story, which was picked up by many news agencies and web sites, indicated that the research was to be published in the journal Forensic Science International.[82]
Highly selected forms of the fiber cultigen possess features maximizing fiber production. Since the nodes tend to disrupt the length of the fiber bundles, thereby limiting quality, tall, relatively unbranched plants with long internodes have been selected. Another strategy has been to select stems that are hollow at the internodes, with limited wood, since this maximizes production of fiber in relation to supporting woody tissues. Similarly, limited seed productivity concentrates the plant’s energy into production of fiber, and fiber cultivars often have low genetic propensity for seed output. Selecting monoecious strains overcomes the problem of differential maturation times and quality of male (staminate) and female (pistillate) plants (males mature 1–3 weeks earlier). Male plants in general are taller, albeit slimmer, less robust, and less productive. Except for the troublesome characteristic of dying after anthesis, male traits are favored for fiber production, in contrast to the situation for drug strains noted below. In former, labor-intensive times, the male plants were harvested earlier than the females, to produce superior fiber. The limited branching of fiber cultivars is often compensated for by possession of large leaves with wide leaflets, which obviously increase the photosynthetic ability of the plants. Since fiber plants have not generally been selected for narcotic purposes, the level of intoxicating constituents is usually limited.
Not until the end of the 20th century was the specific mechanism of action of THC at the neuronal level studied.[citation needed] Researchers have subsequently confirmed that THC exerts its most prominent effects via its actions on two types of cannabinoid receptors, the CB1 receptor and the CB2 receptor, both of which are G protein-coupled receptors.[142] The CB1 receptor is found primarily in the brain as well as in some peripheral tissues, and the CB2 receptor is found primarily in peripheral tissues, but is also expressed in neuroglial cells.[143] THC appears to alter mood and cognition through its agonist actions on the CB1 receptors, which inhibit a secondary messenger system (adenylate cyclase) in a dose-dependent manner. These actions can be blocked by the selective CB1 receptor antagonist rimonabant (SR141716), which has been shown in clinical trials to be an effective treatment for smoking cessation, weight loss, and as a means of controlling or reducing metabolic syndrome risk factors.[144] However, due to the dysphoric effect of CB1 receptor antagonists, this drug is often discontinued due to these side effects.[145]
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