In September 2005, New Scientist reported that researchers at the Canberra Institute of Technology had identified a new type of Cannabis based on analysis of mitochondrial and chloroplast DNA.[81] The New Scientist story, which was picked up by many news agencies and web sites, indicated that the research was to be published in the journal Forensic Science International.[82]
^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
The vast majority of subjects in Sativex clinical trials do not experience psychotropic effects outside of initial dose titration intervals (Figure 2) and most often report subjective intoxication levels on visual analogue scales that are indistinguishable from placebo, in the single digits out of 100 (Wade et al 2006). Thus, it is now longer tenable to claim that psychoactive effects are a necessary prerequisite to symptom relief in the therapeutic setting with a standardized intermediate onset cannabis-based preparation. Intoxication has remained a persistent issue in Marinol usage (Calhoun et al 1998), in contrast.
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Earliest reference to euphoric use of C. sativa appears to date to China of 5 millennia ago, but it was in India over the last millennium that drug consumption became more firmly entrenched than anywhere else in the world. Not surprisingly, the most highly domesticated drug strains were selected in India. While C. sativa has been used as a euphoriant in India, the Near East, parts of Africa, and other Old World areas for thousands of years, such use simply did not develop in temperate countries where hemp was raised. The use of C. sativa as a recreational inebriant in sophisticated, largely urban settings is substantially a 20th century phenomenon.

"Skunk" refers to several named strains of potent cannabis, grown through selective breeding and sometimes hydroponics. It is a cross-breed of Cannabis sativa and C. indica (although other strains of this mix exist in abundance). Skunk cannabis potency ranges usually from 6% to 15% and rarely as high as 20%. The average THC level in coffee shops in the Netherlands is about 18–19%.[254]

I always tell beginners for CBD use to use full-spectrum. The full-spectrum oils contain a lot of terpenes and other good stuff along with CBD and help much more when you suffer from anxiety attacks. CBDistillery also has a wide range of potencies to choose from. Unlike, FabCBD, which offers only limited capacities, CBDistillery’s oils go up to 5000mg per bottle and it is indeed one of the best CBD oils for pain in the market
Receptra offers their products in two separate lines. One is the Active Lifestyle range, which provides lower concentrations for daily use, and another is Health and Wellness, which is for far more intense use. It is incredibly difficult for me to manage my back pain with a low concentration of CBD usually, so, I went with the 3000 mg concentration available in their Health and Wellness line.    
Just as there was a shift from viewing disease as a state to thinking of it as a process, the same shift happened in definitions of health. Again, the WHO played a leading role when it fostered the development of the health promotion movement in the 1980s. This brought in a new conception of health, not as a state, but in dynamic terms of resiliency, in other words, as "a resource for living". 1984 WHO revised the definition of health defined it as "the extent to which an individual or group is able to realize aspirations and satisfy needs and to change or cope with the environment. Health is a resource for everyday life, not the objective of living; it is a positive concept, emphasizing social and personal resources, as well as physical capacities".[10] Thus, health referred to the ability to maintain homeostasis and recover from insults. Mental, intellectual, emotional and social health referred to a person's ability to handle stress, to acquire skills, to maintain relationships, all of which form resources for resiliency and independent living.[9] This opens up many possibilities for health to be taught, strengthened and learned.

The degree to which cannabinoid analgesics will be adopted into adjunctive pain management practices currently remains to be determined. Data on Sativex use in Canada for the last reported 6-month period (January-July 2007) indicated that 81% of prescriptions issued for patients in that interval were refills (data on file, from Brogan Inc Rx Dynamics), thus indicating in some degree an acceptance of, and a desire to, continue such treatment. Given their multi-modality effects upon various nociceptive pathways, their adjunctive side benefits, the efficacy and safety profiles to date of specific preparations in advanced clinical trials, and the complementary mechanisms and advantages of their combination with opioid therapy, the future for cannabinoid therapeutics appears very bright, indeed.
The anti-inflammatory contributions of THC are also extensive, including inhibition of PGE-2 synthesis (Burstein et al 1973), decreased platelet aggregation (Schaefer et al 1979), and stimulation of lipooxygenase (Fimiani et al 1999). THC has twenty times the anti-inflammatory potency of aspirin and twice that of hydrocortisone (Evans 1991), but in contrast to all nonsteroidal anti-inflammatory drugs (NSAIDs), demonstrates no cyclo-oxygenase (COX) inhibition at physiological concentrations (Stott et al 2005a).

^ "Sativex Oral Mucosal Spray Public Assessment Report. Decentralized Procedure" (PDF). United Kingdom Medicines and Healthcare Products Regulatory Agency. p. 93. Retrieved 2015-05-07. There is clear evidence that recreational cannabis can produce a transient toxic psychosis in larger doses or in susceptible individuals, which is said to characteristically resolve within a week or so of absence (Johns 2001). Transient psychotic episodes as a component of acute intoxication are well-documented (Hall et al 1994)


Right now, there’s a good chance that you don’t really know what you’re getting from any source. Testing and labeling rules vary by state, but many states that allow legal cannabis also require some kind of testing to verify that the THC and CBD levels listed on the label are accurate. However, this testing is controversial, and results can vary widely between labs, Jikomes said. A study published in March found measurable variations in test results, with some labs consistently reporting higher or lower levels of cannabinoids than others. There are no guarantees that the label accurately reflects what’s in the product. For a 2015 study published in JAMA, researchers tested 75 products purchased in San Francisco, Los Angeles and Seattle and found that only 17 percent were accurately labeled. More than half of the products contained significantly lower levels of cannabinoids than the label promised, and some of them contained only negligible amounts of the compounds. “We need to come up with ways to confidently verify the composition of cannabis products and make this information available to consumers,” Jikomes said.
Zammit and colleagues’ findings were supported in a 3-year longitudinal study of the relationship between self-reported cannabis use and psychosis in a community sample of 4848 people in the Netherlands (van Os et al., 2002). Van Os and colleagues reported that cannabis use at baseline predicted an increased risk of psychotic symptoms during the follow-up period in individuals who had not reported psychiatric symptoms at baseline. There was a dose–response relationship between frequency of cannabis use at baseline and risk of psychotic symptoms during the follow-up period. These relationships persisted when they statistically controlled for the effects of other drug use. The relationship between cannabis use and psychotic symptoms was also stronger for cases with more severe psychotic symptoms.
Despite the fact that Cannabis was grown on a large scale in many countries, the abuse as a narcotic remained uncommon in Western countries until relatively recently. People were largely unaware of the psychoactive properties of Cannabis and it is unlikely that early cultivars, selected mainly for their seed or fiber qualities, contained significant amounts of the psychoactive THC. The medicinal use of Cannabis was introduced in Europe only around 1840, by a young Irish doctor, William O’Shaughnessy, who served for the East India Trading Company in India, where the medicinal use of Cannabis was widespread. Unlike the European fiber Cannabis, these Indian varieties did contain a reasonable amount of bioactive cannabinoids. In the following decades, the medicinal use of Cannabis saw a short period of popularity both in Europe and in the United States. At the top of its popularity, more than 28 different medicinal preparations were available with Cannabis as active ingredient, which were recommended for indications as various as menstrual cramps, asthma, cough, insomnia, support of birth labor, migraine, throat infection, and withdrawal from opium use.27
Marijuana or marihuana (herbal cannabis),[167] consists of the dried flowers and subtending leaves and stems of the female Cannabis plant.[168][169][170][171] This is the most widely consumed form,[171] containing 3% to 20% THC,[172] with reports of up-to 33% THC.[173] This is the stock material from which all other preparations are derived. Although herbal cannabis and industrial hemp derive from the same species and contain the psychoactive component (THC), they are distinct strains with unique biochemical compositions and uses. Hemp has lower concentrations of THC and higher concentrations of CBD, which decreases the psychoactive effects[174][175] 

Interactions between medications are very common, especially in elderly populations that medicate for pain, diabetes and high cholesterol. The geriatric population is also the fastest-growing group of medical cannabis users. Cannabis has demonstrated efficacy in treating pain, and some phytocannabinoids have been suggested for various metabolic conditions. Thus it is important to understand how... Read more
Specific city and county laws have been enacted to regulate how citizens and tourists may possess and consume marijuana. Penalties exist for driving while under the influence of marijuana. Someone driving under the influence of marijuana is considered impaired in both Colorado and Washington when five nanograms per milliliter (ng/mL) of blood or more of active THC is detected.
I totally agree. The greed of the pharmaceutical with their lobbyist to stop the government from making it a schedule III drug so much more research can be done. They do not care about the people, just money. We the people must rise up and let our government know, we care more about our friends and family than the money they give, to you congress men/women and senators get, and we VOTE. The only power we have is writing or calling congress men/women and senators, huge rallies and each and every ones VOTE. They would rather stay in office, than even receive big monies from big pharm for their campaigns. VOTES will win over.
^ Parliament of the Czech Republic (1998), Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors (in Czech), Prague "Podle čl. 36 Jednotné úmluvy o omamných látkách ze dne 31. března 1961 (č. 47/1965 Sb.) se signatáři zavazují k trestnímu postihu tam uvedených forem nakládání s drogami včetně jejich držby. Návrh upouští od dosavadní beztrestnosti držby omamných a psychotropních látek a jedů pro svoji potřebu. Dosavadní beztrestnost totiž eliminuje v řadě případů možnost postihu dealerů a distributorů drog."
In recent months, both cities and states have moved to control how CBD is sold. Maine and New York City have moved to crack down on edible products containing CBD. New York’s health department confirmed to the New York Times that it has started ordering restaurants to stop selling CBD-laced food because it has not been “deemed safe as a food additive.” 

Going forward, another emerging trend among recreational users are wellness lifestyles built around cannabis. This is certainly part of the influence of California’s new recreational marijuana market, which went online January 1, 2018. California is already an epicenter for health and wellness lifestyles and fads. Expect to see more of the same now that cannabis is completely legal.
Generally, the context in which an individual lives is of great importance for both his health status and quality of their life It is increasingly recognized that health is maintained and improved not only through the advancement and application of health science, but also through the efforts and intelligent lifestyle choices of the individual and society. According to the World Health Organization, the main determinants of health include the social and economic environment, the physical environment and the person's individual characteristics and behaviors.[18]
THC and its major (inactive) metabolite, THC-COOH, can be measured in blood, urine, hair, oral fluid or sweat using chromatographic techniques as part of a drug use testing program or a forensic investigation of a traffic or other criminal offense.[53] The concentrations obtained from such analyses can often be helpful in distinguishing active use from passive exposure, elapsed time since use, and extent or duration of use. These tests cannot, however, distinguish authorized cannabis smoking for medical purposes from unauthorized recreational smoking.[150] Commercial cannabinoid immunoassays, often employed as the initial screening method when testing physiological specimens for marijuana presence, have different degrees of cross-reactivity with THC and its metabolites.[151] Urine contains predominantly THC-COOH, while hair, oral fluid and sweat contain primarily THC.[53] Blood may contain both substances, with the relative amounts dependent on the recency and extent of usage.[53]

I have idiopathic peripheral neuropathy ... the only thing they found that would work is lyrica. I picked up some CBD oil yesterday morning. I am prescribed to take 75 mg of lyrica 3x per day. I took one yesterday morning and have only used the CBD oil since. I bought the Koi brand, flavored, 250 MG. I used a full dropper yesterday late morning and a full dropper yesterday late afternoon. I used it once today (one full dropper) and I am amazingly pain free.
Despite the fact that Cannabis was grown on a large scale in many countries, the abuse as a narcotic remained uncommon in Western countries until relatively recently. People were largely unaware of the psychoactive properties of Cannabis and it is unlikely that early cultivars, selected mainly for their seed or fiber qualities, contained significant amounts of the psychoactive THC. The medicinal use of Cannabis was introduced in Europe only around 1840, by a young Irish doctor, William O’Shaughnessy, who served for the East India Trading Company in India, where the medicinal use of Cannabis was widespread. Unlike the European fiber Cannabis, these Indian varieties did contain a reasonable amount of bioactive cannabinoids. In the following decades, the medicinal use of Cannabis saw a short period of popularity both in Europe and in the United States. At the top of its popularity, more than 28 different medicinal preparations were available with Cannabis as active ingredient, which were recommended for indications as various as menstrual cramps, asthma, cough, insomnia, support of birth labor, migraine, throat infection, and withdrawal from opium use.27 

"In response to DEA actions to block seeds imported by some states in order to grow industrial hemp and to avoid future similar DEA actions to stall full implementation of the hemp provision of the farm bill, Congress acted swiftly. Both the House and Senate FY2015 Commerce-JusticeScience (CJS) appropriations bills contained provisions to block federal law enforcement authorities from interfering with state agencies and hemp growers and counter efforts to obstruct agricultural research. The enacted FY2015 appropriation blocked federal law enforcement authorities from interfering with state agencies, hemp growers, and agricultural research.46 The provision stated that 'none of the funds made available' to the U.S. Justice Department and DEA 'may be used in contravention' of the 2014 farm bill.

In the mid 1990s, the EU provided subsidization for hemp cultivation of ca. $1,050/ha. This support was instrumental in developing a hemp industry in western Europe. However, no comparable support is available in North America, and indeed those contemplating entering into hemp cultivation are faced with extraordinary costs and/or requirements in connection with licensing, security, THC analysis, and record keeping. Those involved in value-added processing and distribution are also faced with legal uncertainties and the regular threat of idiosyncratic, indeed irrational actions of various governments. Simply displaying a C. sativa leaf on advertising has led to the threat of criminal charges in the last decade in several G8 countries. Attempting to export or import hemp products among countries is presently a most uncertain activity.
Fig. 6. ‘Finola,’ the first cultivar of Cannabis sativa bred exclusively for grain. (Courtesy of the breeder, J.C. Callaway, Univ. Kuopio, Finland.) Fig. 7. ‘Anka,’ the first registered North American bred cultivar of Cannabis sativa. This variety is best suited for grain production. (Courtesy of the breeder, P. Dragla, and of the Industrial Hemp Seed Development Company, Chatham, Ontario.)
Ananda Hemp is a tempting brand to say the least. They source their seeds from the largest hemp seed bank in the United States and have generational farmers grow their products. Plus, they offer excellent customer service with their products. However, I was disappointed that they had only two concentrations of tinctures available, one amounting to 200 mg and other being 600 mg.
Chronic pain: The body’s ECS plays a role in alleviating and managing pain, so CBD oil can work as a supplement for individuals with medical conditions that cause chronic pain, such as arthritis and multiple sclerosis. CBD oil also increases levels of adenosine in the brain; adenosine is a neurotransmitter that aids cardiovascular function and eases painful inflammation.
Can CBD oil help anxiety? Cannabidiol (CBD) is a chemical occurring in cannabis plants. It is possible to add CBD oil to food, and an increasing amount of evidence suggests that it may improve mental health, particularly anxiety. It does not seem to have adverse side effects, but CBD oil is illegal in some states. Learn more about CBD oil here. Read now
His third question is whether cannabis serves as a gateway drug. There are two possibilities. The first is that marijuana activates certain behavioral and neurological pathways that ease the onset of more serious addictions. The second possibility is that marijuana offers a safer alternative to other drugs: that if you start smoking pot to deal with chronic pain you never graduate to opioids.
"Skin dryness and itchiness, in particular, are very serious problems in atopic dermatitis, which often lead to additional complications, such as opportunistic infections. In any event, it seems that the reduction of atopic symptomology observed in this study is a direct result of ingested hempseed oil. These preliminary results confirm anecdotal observations of improved skin quality after ingesting modest amounts of hempseed oil on a daily basis over a relatively short period of time."
Other desirable features of hemp fibers are strength and durability (particularly resistance to decay), which made hemp useful in the past for rope, nets, sail-cloth, and oakum for caulking. During the age of sailing ships, Cannabis was considered to provide the very best of canvas, and indeed this word is derived from Cannabis. Several factors combined to decrease the popularity of hemp in the late 19th and early 20th centuries. Increasing limitation of cheap labor for traditional production in Europe and the New World led to the creation of some mechanical inventions, but too late to counter growing interest in competitive crops. Development of other natural fibers as well as synthetic fibers increased competition for hemp’s uses as a textile fiber and for cordage. Hemp rag had been much used for paper, but the 19th century introduction of the chemical woodpulping process considerably lowered demand for hemp. The demise of the sail diminished the market for canvas. Increasing use of the plant for drugs gave hemp a bad image. All this led to the discontinuation of hemp cultivation in the early and middle parts of the 20th century in much of the world where cheap labor was limited. In the 19th century softer fabrics took over the clothing market, and today, hemp constitutes only about 1% of the natural fiber market. At least some production of hemp for fiber still occurs in Russia, China, the Ukraine, Poland, Hungary, the countries of the former Yugoslavia, Romania, Korea, Chile, and Peru. There has been renewed interest in England, Australia, and South Africa in cultivating fiber hemp. Italy has an outstanding reputation for high-quality hemp, but productivity has waned for the last several decades. In France, a market for high-quality paper, ironically largely cigarette paper, has developed (such paper is completely free of the intoxicating resin). Modern plant breeding in Europe has produced several dozen hemp strains, although by comparison with other fiber crops there are relatively few described varieties of hemp. Since World War II, breeding has been concerned most particularly with the development of monoecious varieties. Gehl (1995) reviewed fiber hemp development in Canada in the early 20th century, and concluded that the prospects for a traditional fiber industry were poor. However, as outlined below, there are now many non-traditional usages for hemp fiber which require consideration. Hemp long fiber is one of the strongest and most durable of natural fibers, with high tensile strength, wet strength, and other characteristics that make it technically suited for various industrial products (Karus and Leson 1996). 

A clinical endocannabinoid deficiency has been postulated to be operative in certain treatment-resistant conditions (Russo 2004), and has received recent support in findings that anandamide levels are reduced over controls in migraineurs (Sarchielli et al 2006), that a subset of fibromyalgia patients reported significant decreased pain after THC treatment (Schley et al 2006), and the active role of the ECS in intestinal pain and motility in irritable bowel syndrome (Massa and Monory 2006) wherein anecdotal efficacy of cannabinoid treatments have also been claimed.
Still, Blessing notes, amounts below 100 milligrams haven’t even been tested, so it’s not impossible that small amounts may have some effects. As far as anyone knows, heating up CBD doesn’t degrade its effects, and early evidence suggests that taking it along with high-fat food (like a dessert) aids the body’s absorption of the chemical. Beyond that, all anyone has is guesswork. By Chloe didn’t respond to a detailed list of questions about its sourcing and dosing, but I tried a few of the company’s CBD treats anyway. They were all incredibly tasty, and after consuming three cookies in the course of 24 hours, I accidentally fell asleep on my couch at an indeterminate time of the evening and woke up at 4:30 in the morning. Was it the CBD, or was I just tired? Maybe it was a classic placebo effect, in which I expected to be relaxed and became so.
Cannabis has an ancient history of ritual use and is found in pharmacological cults around the world. Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices like eating by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.[202] It was used by Muslims in various Sufi orders as early as the Mamluk period, for example by the Qalandars.[203] Smoking pipes uncovered in Ethiopia and carbon-dated to around c. AD 1320 were found to have traces of cannabis.[204]
Moreover, a patient survey conducted by Project CBD, declared that “…cannabis appears to be an effective pain management tool with few negative side effects.” The study went on to say that a “…significant decrease in opiate usage among elderly patients while taking medical cannabis [was observed during trial].” In short, it has been portrayed clearly numerous times through valid and well-publicized clinical studies that cannabis is a practical option in terms of efficient pain management.

For example, smoking pot is widely supposed to diminish the nausea associated with chemotherapy. But, the panel pointed out, “there are no good-quality randomized trials investigating this option.” We have evidence for marijuana as a treatment for pain, but “very little is known about the efficacy, dose, routes of administration, or side effects of commonly used and commercially available cannabis products in the United States.” The caveats continue. Is it good for epilepsy? “Insufficient evidence.” Tourette’s syndrome? Limited evidence. A.L.S., Huntington’s, and Parkinson’s? Insufficient evidence. Irritable-bowel syndrome? Insufficient evidence. Dementia and glaucoma? Probably not. Anxiety? Maybe. Depression? Probably not.
Despite advanced analytical techniques, much of the cannabis used recreationally is inaccurately classified. One laboratory at the University of British Columbia found that Jamaican Lamb's Bread, claimed to be 100% sativa, was in fact almost 100% indica (the opposite strain).[83] Legalization of cannabis in Canada (as of October 17, 2018) may help spur private-sector research, especially in terms of diversification of strains. It should also improve classification accuracy for cannabis used recreationally. Legalization coupled with Canadian government (Health Canada) oversight of production and labelling will likely result in more—and more accurate—testing to determine exact strains and content. Furthermore, the rise of craft cannabis growers in Canada should ensure quality, experimentation/research, and diversification of strains among private-sector producers.[84]
Moreover, a patient survey conducted by Project CBD, declared that “…cannabis appears to be an effective pain management tool with few negative side effects.” The study went on to say that a “…significant decrease in opiate usage among elderly patients while taking medical cannabis [was observed during trial].” In short, it has been portrayed clearly numerous times through valid and well-publicized clinical studies that cannabis is a practical option in terms of efficient pain management. 

The major symptom of many short and long-term illnesses is pain, both chronic and acute. Disorders such as Multiple Sclerosis, Diabetic Neuropathy and others, whether derived from the primary or central nervous system, leave patients with unrelenting pain not easily controlled by common pain medications. Although few randomized clinical trials over sufficiently extended periods of time measuring the effects of cannabidiol oil intake on pain management exist, preliminary studies suggest the use of CBD’s in chronic pain management to be useful allowing an increase in quality of life and the ability to rest without pain.  There is some research out there that suggests this might be a good solution for those that are sensitive to other medications as well.  We have attached some Medical publications, News Articles and some videos that touch on this subject.

Use of industrial hemp plant and its cultivation was commonplace until the 1900s, when it was associated with its genetic sibling a.k.a. Drug-Type Cannabis species (which contain higher levels of psychoactive THC). Influential groups misconstrued hemp as a dangerous "drug", even though it is not a 'drug' and it has the potential to be a sustainable and profitable alternative crop.[citation needed][neutrality is disputed]

Specific city and county laws have been enacted to regulate how citizens and tourists may possess and consume marijuana. Penalties exist for driving while under the influence of marijuana. Someone driving under the influence of marijuana is considered impaired in both Colorado and Washington when five nanograms per milliliter (ng/mL) of blood or more of active THC is detected.
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Only a handful of countries have legalized recreational marijuana. Uruguay was one of the first, in 2013. The Netherlands is perhaps the country most known for legal marijuana, yet the drug is illegal there. Spain has given its citizens the rights to grow and consume cannabis privately. Peru also allows citizens to possess marijuana as long as it is for personal, private use. As in Costa Rica, where people can have a “small amount,” without legal trouble.

Fatty Acids. The quality of an oil or fat is most importantly determined by its fatty acid composition. Hemp is of high nutritional quality because it contains high amounts of unsaturated fatty acids, mostly oleic acid (C18:1, 10%–16%), linoleic acid (C18:2, 50%–60%), alpha-linolenic acid (C18:3, 20%–25%), and gamma-linolenic acid (C18:3, 2%–5%) (Fig. 37). Linoleic acid and alpha-linolenic acid are the only two fatty acids that must be ingested and are considered essential to human health (Callaway 1998). In contrast to shorter-chain and more saturated fatty acids, these essential fatty acids do not serve as energy sources, but as raw materials for cell structure and as precursors for biosynthesis for many of the body’s regulatory biochemicals. The essential fatty acids are available in other oils, particularly fish and flaxseed, but these tend to have unpleasant flavors compared to the mellow, slightly nutty flavor of hempseed oil. While the value of unsaturated fats is generally appreciated, it is much less well known that the North American diet is serious nutritionally unbalanced by an excess of linoleic over alpha-linonenic acid. In hempseed, linoleic and alpha-linolenic occur in a ratio of about 3:1, considered optimal in healthy human adipose tissue, and apparently unique among common plant oils (Deferne and Pate 1996). Gamma-linolenic acid or GLA is another significant component of hemp oil (1%–6%, depending on cultivar). GLA is a widely consumed supplement known to affect vital metabolic roles in humans, ranging from control of inflammation and vascular tone to initiation of contractions during childbirth. GLA has been found to alleviate psoriasis, atopic eczema, and mastalgia, and may also benefit cardiovascular, psychiatric, and immunological disorders. Ageing and pathology (diabetes, hypertension, etc.) may impair GLA metabolism, making supplementation desirable. As much as 15% of the human population may benefit from addition of GLA to their diet. At present, GLA is available in health food shops and pharmacies primarily as soft gelatin capsules of borage or evening primrose oil, but hemp is almost certainly a much more economic source. Although the content of GLA in the seeds is lower, hemp is far easier to cultivate and higher-yielding. It is important to note that hemp is the only current natural food source of GLA, i.e. not requiring the consumption of extracted dietary supplements. There are other fatty acids in small concentrations in hemp seed that have some dietary significance, including stearidonic acid (Callaway et al. 1996) and eicosenoic acid (Mölleken and Theimer 1997). Because of the extremely desirable fatty acid constitution of hemp oil, it is now being marketed as a dietary supplement in capsule form (Fig. 38).

It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
Quality is a particular concern, because cannabis plants easily soak up heavy metals from pesticides and other contaminants, Marcu says. If you are buying online, look for a company that documents how it tests its products. (If the website doesn’t indicate this, call and ask.) “Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
Generally, the context in which an individual lives is of great importance for both his health status and quality of their life It is increasingly recognized that health is maintained and improved not only through the advancement and application of health science, but also through the efforts and intelligent lifestyle choices of the individual and society. According to the World Health Organization, the main determinants of health include the social and economic environment, the physical environment and the person's individual characteristics and behaviors.[18]
Grant says this may lead to a “dampening” or mellowing of some neurochemical processes, including those linked to pain. “CBD may also react with other receptors, like those for serotonin, and it may have actions that reduce the inflammatory molecules produced whenever there is tissue damage or bacteria coming in,” he says. “But we really don’t know the mechanisms.”
A recent study of mice with degenerative disc disease found that they experienced improvement with high doses of CBD. Researchers actually found reduced damage to the spin in their experimental population. While the exact mechanism and reasons for these results are unclear, it is certainly promising. More research needs to be done but this is certainly a good start.
Several studies have demonstrated the therapeutic effects of cannabinoids for nausea and vomiting in the advanced stages of illnesses such as cancer and AIDS. Dronabinol (tetrahydrocannabinol) has been available by prescription for more than a decade in the USA. Other therapeutic uses of cannabinoids are being demonstrated by controlled studies, including treatment of asthma and glaucoma, as an antidepressant, appetite stimulant, anticonvulsant and anti-spasmodic, research in this area should continue. For example, more basic research on the central and peripheral mechanisms of the effects of cannabinoids on gastrointestinal function may improve the ability to alleviate nausea and emesis. More research is needed on the basic neuropharmacology of THC and other cannabinoids so that better therapeutic agents can be found.
In the attempt to keep transparent and increase its credibility, Nuleaf Naturals CBD oils are sent to independent laboratories for tests. Tests reveal the concentration and purity standards. Results are published on the official website with links to the authorities conducting it. It is one of the reasons wherefore CBD oils are 100% legal all over the USA.
Unfortunately due to strict FDA regulations I am unable to make claims on our products based on your specific needs, I can however say that CBD is a natural anti-inflammatory and could assist. I can also share our top selling products in each category. Please view the links below:http://cbdoilreview.org/product/elixinol-cbd-oil-extract-x-pen-1000mg/http://cbdoilreview.org/product/endoca-hemp-oil-drops-1500mg/http://cbdoilreview.org/product/elixinol-hemp-oil-drops-regular-300mg/http://cbdoilreview.org/product/elixinol-cbd-hemp-oil-capsules-900mg/https://cbdoilreview.org/product/vape-bright-starter-pack-200-mg/This is also a great link to some pages that you may find helpful https://cbdoilreview.org/cbd-cannabidiol/
Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007).
Pain is physical suffering or discomfort typically caused by illness or injury. Chronic pain is defined as any pain lasting more than 12 weeks. It can persist for months or years. Opiates are the most common treatment for chronic pain, even though substantial research shows that they are not effective. About 60% of people suffering from chronic pain are women.
The vast majority of subjects in Sativex clinical trials do not experience psychotropic effects outside of initial dose titration intervals (Figure 2) and most often report subjective intoxication levels on visual analogue scales that are indistinguishable from placebo, in the single digits out of 100 (Wade et al 2006). Thus, it is now longer tenable to claim that psychoactive effects are a necessary prerequisite to symptom relief in the therapeutic setting with a standardized intermediate onset cannabis-based preparation. Intoxication has remained a persistent issue in Marinol usage (Calhoun et al 1998), in contrast.
An important way to maintain your personal health is to have a healthy diet. A healthy diet includes a variety of plant-based and animal-based foods that provide nutrients to your body. Such nutrients give you energy and keep your body running. Nutrients help build and strengthen bones, muscles, and tendons and also regulate body processes (i.e. blood pressure). The food guide pyramid is a pyramid-shaped guide of healthy foods divided into sections. Each section shows the recommended intake for each food group (i.e. Protein, Fat, Carbohydrates, and Sugars). Making healthy food choices is important because it can lower your risk of heart disease, developing some types of cancer, and it will contribute to maintaining a healthy weight.[44]
Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.
In the early 1990s, industrial hemp agriculture in North America began with the Hemp Awareness Committee at the University of Manitoba. The Committee worked with the provincial government to get research and development assistance, and was able to obtain test plot permits from the Canadian government. Their efforts led to the legalization of industrial hemp (hemp with only minute amounts of tetrahydrocannabinol) in Canada and the first harvest in 1998.[82][83]
Yet Germany’s health insurance companies, doctors, and pharmacies weren’t prepared for the rush. Prior to legalization, cannabis represented a small niche in the country with just a thousands patients with access to the drug because of a special permit. But legalization spawned a rapid growth; in 2018 alone, there were 142,000 prescriptions issued.
I do hope this will be approved since the one was approved of someone attacking marijuanna supporting opiate pills yet lying on marijuanna to keep rights to their pain pills. First no I don’t agree the handling of how the war on opiates were done, its lead to sky rocketing of heroin not just for high some pain as they felt it all they had left but but becomes problem fast, heroin is the end of the line solution ! Patients like me stage 4 cancer up recurrence were just cold turkey took off left pain meds left to feel cancer and opiate withdrawal pain. I too never overtook my pain meds. You don’t have to be addicted you will become dependent as your body will stop making natural opiate receptors. Two years of pure suffering goes by and I give in to medical marijuana and cannibas oil and my life changed! I went from hospice 2mo max to hospice leaving my health improved so much! A surgery where tumors on bile ducts, liver was cancelled, the pain gone vomiting stopped and MRI confirmed tumors gone. So sorry if taken little offense to sthg be said sthg like “they making marijuana legal & these younger-older folks get high while I take my opiates as presribed & they save me” as I don’t care much for the head feeling of marijuanna if was honest give me the feeling from an opiate anyday. No-one thinks they have a problem with pain pills for most dangerous reasons “my doctor gave to me, i take only as needed, its legal” other than pain relief & quality of life opiates give you no saving your life. Opiates can not cure conditions, slow or kill cancer or near what cannibas-marijuanna is known to do. Until medical marijuana I continued to slowly lose my battle to cancer, not blaming pain meds at all only saying they provided no medical benefit other than pain relief and pleasure feeling. Upon the marijuana..it medical miracle..went from dying with 2mo left to live here 8mo later putting makeup on again living. I only use minimum amount early morning and late night. I have went on to teach myself about other things like enzymes and other plant life to alkaline, anti-inflammatory my body. I support opiates when needed but highly support medical marijuana and cannibas oil.. I just don’t think to inform others educationaly something that is not true judging others. Marijuana is not addictive unless the brain is not fully developed but even then in kids it can save their life: seizures etc. Noone has ever overdosed or died of marijuana per DEA. You can’t say that for opiates. Although I advocate for being fair to true pain patients on opiates. I also advocate to legalize marijuanna but because someone has a preference or dependency on one should not make them want them come to a forum helping so many medically to advocate for their vice to insult others medical choice… Read more »
Marijuana is the most popular illicit drug in the world, for no reason other than the fact that it produces a psychoactive chemical called tetrahydrocannabinol. Still, recreational marijuana use, which involves pursuing the euphoric sensations produced by cannabis consumption, is steadily becoming more and more legal, both in the United States and abroad.

After fighting the effects of thyroid cancerfor 12 years I wanted to die. Every day. Now, please understand that these were thoughts with no actions, I was just miserable in pain.After 1 week on the CBD oil, (5 drops under the toungue 2x per day) I am a different woman. I now have hope. Some of my emotional pain is presenting as physical pain, but IT'S LEAVING MY BODY.
ECS is made up of endocannabinoids and the receptors associated with them. These receptors are literally found from head to toe, and are in such places as the glands, organs, and the brain. While receptors and endocannabinoids are located in all parts of the body, they have different functions depending upon where they are located, with the primary role being to regulate what is referred to as homeostasis or the regulation of the body so that it is at equilibrium.
"Results of the hemp products tested indicate the amount of THC present in commercially available products is significantly less in products available today than those reported in the past (15-22). As a result, the probability that these products will produce urine THC metabolite levels greater than the DoD and HHS confirmation cutoff of 15 ng/mL is significantly reduced and should not be considered as a realistic cause for a positive urine analysis result."
Stephanie, generally, I have patients take 20 to 150mg a day for sleep +/- anxiety. Start low and go slow. Know the dosages of your product. Usually 2/3 to 3/4 of the daily dose is 1-2 hours before bedtime, and the other portion is upon waking (to improve wakefulness during the day). Other factors such as stress, hormone replacement, other meds & medical conditions, etc. play a role along with individual differences. I own a compounding pharmacy, so we see a lot of unique needs. I can't give more specific advice in this forum, but there is help!
Thanks Donna, for great share! I use cbd oil every day. I refuse to go without it. I have no arthritic pain at all anymore. I had a hip replacement 3 years ago. I am in need of the other one to be replaced. I was laying awake crying at night because of my hip pain. After I started using the oil my hip has quit aching. I sometimes forget I even have a problem with it or my arthritis. Had I known about the oil before I had my hip replaced I never would have had the surgery. I am pain free. I use hemp oil. There are 20 mg of cannabiniol in each 1 ml dose https://cbdreamers.com/cbd-oil-for-pain

Feminized cannabis seeds are designed to produce only female plants.Usually, a cannabis seed can develop into a male or female plant; the entire process is determined by the sex expressing X and Y chromosomes. "Feminization" is a process of conditioning female plants to obtain male pollen needed for seed production.A plant with two X chromosomes will be female 99% of the time, while regular cannabis seeds (XY genetic set) sometimes have a tendency to produce more male than female individuals.
Cannabis use is associated with increased recruitment of task-related areas, such as the dorsolateral prefrontal cortex, which is thought to reflect compensatory activity due to reduced processing efficiency.[114][113][116] Cannabis use is also associated with downregulation of CB1 receptors. The magnitude of down regulation is associated with cumulative cannabis exposure, and is reversed after one month of abstinence.[117][118][119] There is limited evidence that chronic cannabis use can reduce levels of glutamate metabolites in the human brain.[120]
Some jurisdictions use free voluntary treatment programs and/or mandatory treatment programs for frequent known users. Simple possession can carry long prison terms in some countries, particularly in East Asia, where the sale of cannabis may lead to a sentence of life in prison or even execution. Political parties, non-profit organizations, and causes based on the legalization of medical cannabis and/or legalizing the plant entirely (with some restrictions) have emerged in such countries as China and Thailand.[225][226]
38 states and Puerto Rico considered legislation related to industrial hemp in 2017. These bills ranged from clarifying existing laws to establishing new licensing requirements and programs.  At least 15 states enacted legislation in 2017 — Arkansas, Colorado, Florida, Hawaii, North Dakota, Nevada, New York, Oregon, South Carolina, Tennessee, Virginia, Washington, West Virginia, Wisconsin and Wyoming. At least four states — Florida, Nevada, New Mexico and Wisconsin — authorized new research or pilot programs. 
This is not stated to discourage the use of the product because I have read…..some patients have had some efffective relief wth CBD oil but, pain managment is subjective to each individual patient even with opioid medicatios, Research, asking questions is important and the representatives of CBD oil product providers are more than willing to talk to you. There are different ways that the product is extracted from the plant. One in particular seems quite dangerous to me. Read for yourself. Again I do not discourage trying the product. Some, a great deal of patients are even reporting effective pain management with other products such as “kratom”. Again this product is not FDA approved and has no quality control regulation. Word of mouth amd sometimes great reviews but, again pain is subjective to each patient.
^ Hayakawa K, Mishima K, Hazekawa M, Sano K, Irie K, Orito K, Egawa T, Kitamura Y, Uchida N, Nishimura R, Egashira N, Iwasaki K, Fujiwara M (January 2008). "Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB(1) receptor-dependent mechanism". Brain Research. 1188: 157–64. doi:10.1016/j.brainres.2007.09.090. PMID 18021759.
The Food and Drug Administration (FDA) does not consider CBD or products that contain CBD to be dietary supplements. This is because CBD has been studied and approved for use as a new drug to treat epilepsy, which means it is outside the definition of a dietary supplement.5 There may be products available that are marked as dietary supplements, however the amount of cannabidiol they claim to contain may not be accurate.

Years passed, and more studies rolled out with medically beneficial findings regarding cannabis until 2009 when Steep Hill Laboratory in Oakland, California, tested cannabis samples provided by Harborside Health Center to discover that a handful of cultivars contained more CBD than THC. This discovery kicked other labs into gear. They wanted to study medical cannabis to understand and potentially calibrate their cannabinoid ratios. Soon thereafter, laboratories uncovered CBD-dominant strains boasting 20:1 CBD to THC ratios, which opened up the cannabis market for a panoply of CBD products.


Like everything else in the U.S it is buyer beware. I was told that the 30 dollar a bottle Hemp Oil, would not work becasue I was “Skeptical.” I had asked exactly these questions at a Dispensary. The CBD Craze is mostly hype. It does little or nothing for pain, or anything else. The only thing I have seen is that when it is derived from marijuana in the for of a Salve with the a small amount of THC in it, it might help with arthritis topically.
Thapa, D., Toguri, J. T., Szczesniak, A. M., & Kelly, A. E. M. (2017, April 1). The non-psychoactive phytocannabinoid, cannabidiol (CBD), and the synthetic derivatives, HU308 and CBD-DMH, reduces hyperalgesia and inflammation in a mouse model of corneal injury [Abstract]. FASEB Journal. Retrieved from https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.811.7

Male hemp plants flower much faster than females and do not produce nearly as much fiber. In stark contrast to marijuana fields, most female hemp fields include sporadically placed males. The male hemp plants release pollen for the female hemp plant to produce seeds that will either be used for future crops or sold as food. In marijuana fields, males are typically eliminated to ensure the maximum production of sensimilla flowers.
The CBD oil from American Shaman are entirely manufactured by pharmacists. This is not the type of product whose manufacturing process you know nothing about, but a perfectly transparent one created by professionals with experience. It is 100% organic – no chemicals or artificial components. Besides, despite the high concentration of CBD, it is perfectly legal and it does not require a medical prescription.
Cannabis drug preparations have been employed medicinally in folk medicine since antiquity, and were extensively used in western medicine between the middle of the 19th century and World War II, particularly as a substitute for opiates (Mikuriya 1969). A bottle of commercial medicinal extract is shown in Fig. 41. Medical use declined with the introduction of synthetic analgesics and sedatives, and there is very limited authorized medical use today, but considerable unauthorized use, including so-called “compassion clubs” dispensing marijuana to gravely ill people, which has led to a momentous societal and scientific debate regarding the wisdom of employing cannabis drugs medically, given the illicit status. There is anecdotal evidence that cannabis drugs are useful for: alleviating nausea, vomiting, and anorexia following radiation therapy and chemotherapy; as an appetite stimulant for AIDS patients; for relieving the tremors of multiple sclerosis and epilepsy; and for pain relief, glaucoma, asthma, and other ailments [see Mechoulam and Hanus (1997) for an authoritative medical review, and Pate (1995) for a guide to the medical literature]. To date, governmental authorities in the US, on the advice of medical experts, have consistently rejected the authorization of medical use of marijuana except in a handful of cases. However, in the UK medicinal marijuana is presently being produced sufficient to supply thousands of patients, and Canada recently authorized the cultivation of medicinal marijuana for compassionate dispensation, as well as for a renewed effort at medical evaluation.
In fact, many kinds of pains related to specific systems of the body can be managed more effectively through the use of cannabidiol oil. Many use CBD oil for muscle pain, but CBD oil for nerve pain is just as effective. What has been discovered is that the effectiveness of CBD oil for neuropathic pain in general is what is making this such a wonder remedy for so many different kinds of issues related to pain.

Even those who are facing issues related to mental health should consult their physician. Research studies continue to examine the effects and benefits of this drug far beyond just anxiety and depression. The benefits for those facing schizophrenia may be just the tip of the iceberg, as this may help with such conditions as mania and other forms of psychosis with further research.
had relief. I also rubbed some on a couple of sour spots near my back, and it seems to have helped. Im also, in a better mood, I feel more alert and more full of energy. Now, I haven’t been taking it long enough to make a full decision on its benefits, but for now I’m going to continue the use of it because it seems to be working. I believe it to be the thing of the future!

An alternative to the gateway hypothesis is the common liability to addiction (CLA) theory. It states that some individuals are, for various reasons, willing to try multiple recreational substances. The "gateway" drugs are merely those that are (usually) available at an earlier age than the harder drugs. Researchers have noted in an extensive review that it is dangerous to present the sequence of events described in gateway "theory" in causative terms as this hinders both research and intervention.[271]
Nuleaf Naturals has gained popularity with its CBD oils and transparency for its operations. The CBD oil comes in more sizes and is known for having a high concentration of CBD. For example, a small 5ml bottle has 240mg of CBD oil in its composition. It may be less powerful than top providers in this industry, but the good value for money and efficiency in pain relief will most likely convince potential customers.
"The CSA [Controlled Substances Act] classifies marijuana in the first category of schedules, placing it among the most harmful and dangerous drugs.137 Marijuana meets the criteria for a Schedule I controlled substance because of its THC content, which is a psychoactive hallucinogenic substance with a high potential for abuse.138 Another key classification made by the CSA regarding marijuana was its broad definition of the drug.139 The CSA defines marijuana as follows:

I am a former family doctor and naturopathic physician as well as a medical editor and author, working mostly in academic research. In my practice I have always focused on natural medicine and helped my patients of all ages who haven’t responded to traditional treatments. I also have written a significant number of articles in botanical medicine, addiction, drugs. As of now I'm focused on cannabis researches, especially on cannabidiol, its health benefits and how it can improve life of people with severe diseases. You can read my articles here on CBDreamers
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