Hemp paper are paper varieties consisting exclusively or to a large extent from pulp obtained from fibers of industrial hemp. The products are mainly specialty papers such as cigarette paper,[41] banknotes and technical filter papers.[42] Compared to wood pulp, hemp pulp offers a four to five times longer fibre, a significantly lower lignin fraction as well as a higher tear resistance and tensile strength. However, production costs are about four times higher than for paper from wood,[43] so hemp paper could not be used for mass applications as printing, writing and packaging paper.
Everything you need to know about marijuana (cannabis) Marijuana, or cannabis, is the most commonly used illicit drug in the world. It alters the mood and affects nearly every organ in the body. With at least 120 active compounds, marijuana may have health benefits as well as risks. We describe these, addiction, and withdrawal. Learn more about cannabis here. Read now
Last year, the National Academies of Sciences, Engineering and Medicine released a nearly 500-page report on the health effects of cannabis and cannabinoids. A committee of 16 experts from a variety of scientific and medical fields analyzed the available evidence — more than 10,000 scientific abstracts in all. Because so few studies examine the effects of CBD on its own, the panel did not issue any findings about CBD specifically, but it did reach some conclusions about cannabis and cannabinoids more generally. The researchers determined that there is “conclusive or substantial evidence” supporting the use of cannabis or cannabinoids for chronic pain in adults, multiple sclerosis-related spasticity (a kind of stiffness and muscle spasms), and chemotherapy-induced nausea and vomiting. The committee also found “moderate” evidence that cannabis or cannabinoids can reduce sleep disturbances in people with obstructive sleep apnea, fibromyalgia, chronic pain and multiple sclerosis, as well as “limited” evidence that these substances can improve symptoms of Tourette’s syndrome, increase appetite and stem weight loss in people with HIV/AIDs, and improve symptoms of PTSD and anxiety.

Pain from inflammation can and will likely affect all adults at some point in their lives, and for some, become chronic conditions that interfere with a normal quality of life. Over-the-counter (OTC) and prescription anti-inflammatory medications are easily available, readily prescribed, and very commonly used.  The most common anti-inflammatory medications are called NSAIDs: non-steroidal... Read more
In 2015, The Hebrew University of Israel published a study that documented the potency of single-molecule CBD extract versus the potency of whole-plant CBD-rich extract. It found that extract taken from whole plant CBD-rich cannabis is therapeutically superior to single-molecule extract. The scientists behind this study noticed that science had been utilizing pure, single-molecule CBD, which resulted in a bell-shaped dose-response curve. This means that CBD’s efficacy plummets at very high and very low doses.

France is Europe's biggest producer (and the world's second largest producer) with 8,000 hectares (20,000 acres) cultivated.[85] 70–80% of the hemp fibre produced in 2003 was used for specialty pulp for cigarette papers and technical applications. About 15% was used in the automotive sector, and 5-6% was used for insulation mats. About 95% of hurds were used as animal bedding, while almost 5% was used in the building sector.[14] In 2010/2011, a total of 11,000 hectares (27,000 acres) was cultivated with hemp in the EU, a decline compared with previous year.[72][86]
In a study with HIV-positive adult men, blood concentrations of ghrelin and other appetitive hormones (leptin, PYY, and insulin) were tested after having received smoked medicinal cannabis or matched placebo for HIV-associated neuropathic pain. Cannabis administration, as compared to placebo, significantly increased ghrelin concentrations in this study. In addition, leptin and PYY levels were, respectively, increased and decreased, but no impact on insulin levels was found (Riggs et al., 2012).
^ Jump up to: a b c Whiting, PF; Wolff, RF; Deshpande, S; Di Nisio, M; Duffy, S; Hernandez, AV; Keurentjes, JC; Lang, S; Misso, K; Ryder, S; Schmidlkofer, S; Westwood, M; Kleijnen, J (23 June 2015). "Cannabinoids for Medical Use: A Systematic Review and Meta-analysis" (PDF). JAMA. 313 (24): 2456–2473. doi:10.1001/jama.2015.6358. hdl:10757/558499. PMID 26103030.
Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.[80]
Fig. 8. Scanning electron micrographs of the abaxial surface of a perigonal bract (which envelops the fruit). These bracts are the most intoxicating part of the plant, and may contain 20% THC, dry weight. The resin is synthesized both in stalked and sessile glands. Multicellular secretory glands (of phallic appearance), some broken stalks of these (note cellular appearance), and unicellular cystolith hairs (claw-like structures) are pictured. Fig. 9. Some important cannabinoids of cannabis resin. D9-THC (delta-9 tetrahydrocannabinol) is the chief intoxicant chemical and predominates in intoxicant strains, while the isomer D8-THC is usually present in no more than trace amounts. CBD (cannabidiol) is the chief non-intoxicant chemical, and predominates in non-intoxicant strains; it has sedative effects. The non-intoxicant CBN (cannabinol) is a frequent degradation or oxidation product. The non-intoxicant cannabichromene (CBC) is typically found in trace amounts in intoxicant strains. The non-intoxicant cannabigerol (CBG) is considered to be a precursor of the other cannbinoids (see Fig. 10).
Despite the fact that Cannabis was grown on a large scale in many countries, the abuse as a narcotic remained uncommon in Western countries until relatively recently. People were largely unaware of the psychoactive properties of Cannabis and it is unlikely that early cultivars, selected mainly for their seed or fiber qualities, contained significant amounts of the psychoactive THC. The medicinal use of Cannabis was introduced in Europe only around 1840, by a young Irish doctor, William O’Shaughnessy, who served for the East India Trading Company in India, where the medicinal use of Cannabis was widespread. Unlike the European fiber Cannabis, these Indian varieties did contain a reasonable amount of bioactive cannabinoids. In the following decades, the medicinal use of Cannabis saw a short period of popularity both in Europe and in the United States. At the top of its popularity, more than 28 different medicinal preparations were available with Cannabis as active ingredient, which were recommended for indications as various as menstrual cramps, asthma, cough, insomnia, support of birth labor, migraine, throat infection, and withdrawal from opium use.27
• Speaking of which: Has it been third-party tested? Nearly every expert Health spoke to agreed that your CBD products should be tested by a third party to confirm the label's accuracy. This is a real concern in the industry—take the 2017 Journal of the American Medical Association study, for example, which tested 84 CBD products and found that 26% contained lower doses than stated on the bottle. Look for a quality assurance stamp or certificate of analysis from a third party (aka not the actual brand) or check the retailer's website if you don't see it on the product's label.
This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Tetrahydrocannabinol (THC, Marinol®) and nabilone (Cesamet®) are currently approved in the United States and other countries, but not for pain indications. Other synthetic cannabinoids, such as ajulemic acid, are in development. Crude herbal cannabis remains illegal in most jurisdictions but is also under investigation. Sativex®, a cannabis derived oromucosal spray containing equal proportions of THC (partial CB1 receptor agonist ) and cannabidiol (CBD, a non-euphoriant, anti-inflammatory analgesic with CB1 receptor antagonist and endocannabinoid modulating effects) was approved in Canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain. An Investigational New Drug application to conduct advanced clinical trials for cancer pain was approved by the US FDA in January 2006. Cannabinoid analgesics have generally been well tolerated in clinical trials with acceptable adverse event profiles. Their adjunctive addition to the pharmacological armamentarium for treatment of pain shows great promise.
Researchers in New Zealand have studied whether cannabis can be used to treat severe motor and vocal tics in those suffering from Tourette syndrome. The study concluded that subjects who took a controlled THC-CBD medicated spray showed marked improvement in the frequency and severity of motor and vocal tics post-treatment. Although the study is only a small clinical trial, it is one of the first to specifically analyze the effects of cannabis on Tourette syndrome.
Until recent times, the cultivation of hemp primarily as an oilseed was largely unknown, except in Russia. Today, it is difficult to reconstruct the type of plant that was grown there as an oilseed, because such cultivation has essentially been abandoned. Oilseed hemp cultivars in the modern sense were not available until very recently, but some land races certainly were grown specifically for seeds in Russia. Dewey (1914) gave the following information: “The short oil-seed hemp with slender stems, about 30 inches high, bearing compact clusters of seeds and maturing in 60 to 90 days, is of little value for fiber production, but the experimental plants, grown from seed imported from Russia, indicate that it may be valuable as an oil-seed crop to be harvested and threshed in the same manner as oil-seed flax.” Most hemp oilseed in Europe is currently obtained from so-called “dual usage” plants (employed for harvest of both stem fiber and seeds, from the same plants). Of the European dual-usage cultivars, ‘Uniko B’ and ‘Fasamo’ are particularly suited to being grown as oilseeds. Very recently, cultivars have been bred specifically for oilseed production. These include ‘Finola,’ formerly known as ‘Fin-314’ (Fig. 6) and ‘Anka’ (Fig. 7), which are relatively short, little-branched, mature early in north-temperate regions, and are ideal for high-density planting and harvest with conventional equipment. Dewey (1914) noted that a Turkish narcotic type of land race called “Smyrna” was commonly used in the early 20th century in the US to produce birdseed, because (like most narcotic types of Cannabis) it is densely branched, producing many flowers, hence seeds. While oilseed land races in northern Russia would have been short, early-maturing plants in view of the short growing season, in more southern areas oilseed landraces likely had moderate height, and were spaced more widely to allow abundant branching and seed production to develop. Until Canada replaced China in 1998 as a source of imported seeds for the US, most seeds used for various purposes in the US were sterilized and imported from China. Indeed, China remains the largest producer of hempseed. We have grown Chinese hemp land races, and these were short, branched, adapted to a very long growing season (i.e. they come into flower very slowly in response to photoperiodic induction of short days in the fall), and altogether they were rather reminiscent of Dewey’s description of Smyrna. Although similar in appearance to narcotic strains of C. sativa, the Chinese land races we grew were in fact low in intoxicating constituents, and it may well be that what Dewey thought was a narcotic strain was not. Although some forms of C. sativa have quite large seeds, until recently oilseed forms appear to have been mainly selected for a heavy yield of seeds, usually recognizable by abundant branching. Such forms are typically grown at lower densities than hemp grown only for fiber, as this promotes branching, although it should be understood that the genetic propensity for branching has been selected. Percentage or quality of oil in the seeds does not appear to have been important in the past, although selection for these traits is now being conducted. Most significantly, modern selection is occurring with regard to mechanized harvesting, particularly the ability to grow in high density as single-headed stalks with very short branches bearing considerable seed.
Szaflarski explains that cannabis contains about 500 different compounds, some of which—including CBD and THC—interact with certain chemical receptors in the human nervous system. But unlike THC, CBD isn’t psychoactive—meaning it doesn’t cause any kind of a high. Despite that, the US Drug Enforcement Agency classifies CBD (and other cannabis compounds) as schedule I substances, making their sale illegal in many states.

Late last year, the commissioner of the Food and Drug Administration, Scott Gottlieb, announced a federal crackdown on e-cigarettes. He had seen the data on soaring use among teen-agers, and, he said, “it shocked my conscience.” He announced that the F.D.A. would ban many kinds of flavored e-cigarettes, which are especially popular with teens, and would restrict the retail outlets where e-cigarettes were available.

"In the past there has been ongoing tension between federal and state authorities over state hemp policies. After North Dakota passed its own state law authorizing industrial hemp production in 1999,62 researchers repeatedly applied for, but did not receive, a DEA permit to cultivate hemp for research purposes in the state.63 Also in 2007, two North Dakota farmers were granted state hemp farming licenses and, in June 2007, filed a lawsuit in U.S. District Court (North Dakota) seeking 'a declaratory judgment' that the CSA 'does not prohibit their cultivation of industrial hemp pursuant to their state licenses.'64 The case was dismissed in November 2007.65 The case was appealed to the U.S. Court of Appeals (Eighth Circuit) but was again dismissed in December 2009.66 The farmers filed an appeal in May 2010.67

A wide variety of hemp clothing, footwear, and food products are now available in North America. Some American manufacturers and distributors have chosen to exploit the association of hemp products with marijuana in their advertising. Such marketing is unfortunate, sending the message that some in the industry are indifferent to the negative image that this generates in the minds of much of the potential consuming public. Admittedly, such advertising works. But marketing based on the healthful and tasteful properties of hemp food products, the durable nature of hemp textiles, and the environmental advantages of the crop has proven to be widely acceptable, and is likely to promote the long term development of hemp industries.
"Many EU countries lifted their bans on hemp production in the 1990s and, until recently, also subsidized the production of 'flax and hemp' under the EU’s Common Agricultural Policy.32 EU hemp acreage was reported at about 26,000 acres in 2010, which was below previous years, when more than 50,000 acres of hemp were under production.33 Most EU production is of hurds, seeds, and fibers. Other non-EU European countries with reported hemp production include Russia, Ukraine, and Switzerland. Other countries with active hemp grower and/or consumer markets are Australia, New Zealand, India, Japan, Korea, Turkey, Egypt, Chile, and Thailand."
Cannador® (IKF-Berlin) is a cannabis extract administered in oral capsules, with differing figures as to THC:CBD ratios (reviewed in (Russo and Guy 2006)), generally approximately 2:1. Two pharmacokinetic studies on possibly related material have been reported (Nadulski et al 2005a; Nadulski et al 2005b). In a Phase III RCT employing Cannador in spasticity in multiple sclerosis (MS) (CAMS) (Zajicek et al 2003) (Table 1), no improvement was noted in the Ashworth Scale, but benefit was observed in spasm-associated pain on subjective measures. Both Marinol and Cannador produced reductions in pain scores in long-term follow-up (Zajicek et al 2005). Cannador was assayed in postherpetic neuralgia in 65 subjects with no observed benefit (Ernst et al 2005) (Table 1), and in 30 post-operative pain subjects (CANPOP) without opiates, with slight benefits, but prominent psychoactive sequelae (Holdcroft et al 2006) (Table 1).
But, uh, what is it that CBD is supposed to do? I visited a cannabis dispensary in Boulder to find out what the hype was all about. After passing an ID check, I was introduced to a “budtender” who pointed me to an impressive array of CBD products — tinctures, skin patches, drink powders, candies, salves, massage oil, lotions, “sexy time personal intimacy oil” and even vaginal suppositories to treat menstrual cramps.
“Hemp” refers primarily to Cannabis sativa L. (Cannabaceae), although the term has been applied to dozens of species representing at least 22 genera, often prominent fiber crops. For examples, Manila hemp (abaca) is Musa textilis Née, sisal hemp is Agave sisalina Perrine, and sunn hemp is Crotolaria juncea L. Especially confusing is the phrase “Indian hemp,” which has been used both for narcotic Asian land races of C. sativa (so-called C. indica Lamarck of India) and Apocynum cannabinum L., which was used by North American Indians as a fiber plant. Cannabis sativa is a multi-purpose plant that has been domesticated for bast (phloem) fiber in the stem, a multi-purpose fixed oil in the “seeds” (achenes), and an intoxicating resin secreted by epidermal glands. The common names hemp and marijuana (much less frequently spelled marihuana) have been applied loosely to all three forms, although historically hemp has been used primarily for the fiber cultigen and its fiber preparations, and marijuana for the drug cultigen and its drug preparations. The current hemp industry is making great efforts to point out that “hemp is not marijuana.” Italicized, Cannabis refers to the biological name of the plant (only one species of this genus is commonly recognized, C. sativa L.). Non-italicized, “cannabis” is a generic abstraction, widely used as a noun and adjective, and commonly (often loosely) used both for cannabis plants and/or any or all of the intoxicant preparations made from them.
The Marijuana business has become like a Cult. They whole heartedly ‘Believe” it cures cancer and a host of other issues. A local University “Researcher” has moved in to provide more pseudo science with a narrow, self selected “Survey.” The results or lack of Scientific rigor don’t matter to these people, it is more profitable to ignore the facts and science. They already believe that Medical Marijuana can replace pain medications for chronic pain.
Cannabidiol (CBD) and tetrahydrocannabinol (THC) are two compounds found within the cannabis plant that are showing promise as pain relievers. And as the legalization of cannabis continues to spread, and as researchers continue to study the plant’s therapeutic potential, the stigma will continue to disappear. The number of people using CBD for pain relief is on the rise, showing that cannabis, and the cannabinoids it produces, can do so much more than produce an intoxicating high, it can actually help heal.
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Fig. 8. Scanning electron micrographs of the abaxial surface of a perigonal bract (which envelops the fruit). These bracts are the most intoxicating part of the plant, and may contain 20% THC, dry weight. The resin is synthesized both in stalked and sessile glands. Multicellular secretory glands (of phallic appearance), some broken stalks of these (note cellular appearance), and unicellular cystolith hairs (claw-like structures) are pictured. Fig. 9. Some important cannabinoids of cannabis resin. D9-THC (delta-9 tetrahydrocannabinol) is the chief intoxicant chemical and predominates in intoxicant strains, while the isomer D8-THC is usually present in no more than trace amounts. CBD (cannabidiol) is the chief non-intoxicant chemical, and predominates in non-intoxicant strains; it has sedative effects. The non-intoxicant CBN (cannabinol) is a frequent degradation or oxidation product. The non-intoxicant cannabichromene (CBC) is typically found in trace amounts in intoxicant strains. The non-intoxicant cannabigerol (CBG) is considered to be a precursor of the other cannbinoids (see Fig. 10).
It makes no sense to me that something that helps with anxiety has an irritability side effect – as a lot of my anxiety is co-mingled naturally with irritability. Further, I have noticed none of these side effects, given that if you become fatigued or sleepy, you adjust dose the next day. So I don’t call that a side effect – rather – an effect of taking too much.
"Hemp oil is extremely nutritious, and is used in foods and nutraceutical products for humans and animals, as well as in personal care products. Hemp oil is also suitable for use in industrial products such as paints, varnishes, inks and industrial lubricants, and can be used to produce biodiesel. The crushed seed meal left over from oil production is frequently used for animal feed."
The US Drug Enforcement Administration’s online criminal justice statistics for 2000 (cscmosaic.albany.edu/sourcebook/1995/pdf/t440.pdf) shows the following seizures and eradication of plants of C. sativa: 40,929 outdoor plots (2,597,796 plants), 139,580,728 ditchweed (ruderal plants), 2,361 indoor operations (217,105 plants), for a grand total of 2,814, 903 plants destroyed. Impressively, the species was grown in all 50 states (including outdoor seizures in every state except Wyoming)! It is of course impossible to know exactly how much marijuana is cultivated in the United States, and perhaps only 10% to 20% of the amount grown is seized. The profitability of the illegal crop is indicated by a comparison of the cost of a bushel of corn (roughly $2.50) and a bushel of manicured marijuana (about $70,000; it has been suggested that prices range from $500 a pound, for low-quality marijuana, to more than $5,000 a pound for “boutique” strains like “Northern Lights” and “Afghan Kush”). According to a National Organization for the Reform of Marijuana Laws (NORML) (mir.drugtext.org/marijuananews/marijuana_ranks_fourth_largest_c.htm) marijuana is at least the fourth most valuable crop in America, outranked only by corn, soybeans, and hay. It was estimated that 8.7 million marijuana plants were harvested in 1997, worth $15.1 billion to growers and $25.2 billion on the retail market (the wholesale value was used to compare marijuana to other cash crops). Marijuana was judged to be the largest revenue producing crop in Alabama, California, Colorado, Hawaii, Kentucky, Maine, Rhode Island, Tennessee, Virginia, and West Virginia, and one of the top five cash crops in 29 other states.
Based on reviews, smoking or vaporizing CBD vape oil seems to have less effects when compared to other methods of administering CBD, such as tinctures, capsules and sprays. On the flip side, others argue that smoking or vaporizing has less drawbacks than taking CBD orally, since ingesting CBD orally could result in inconsistent absorption and a delayed effect.

A limited number of studies have examined the effects of cannabis smoking on the respiratory system.[89] Chronic heavy marijuana smoking is associated with coughing, production of sputum, wheezing, and other symptoms of chronic bronchitis.[69] The available evidence does not support a causal relationship between cannabis use and chronic obstructive pulmonary disease.[90] Short-term use of cannabis is associated with bronchodilation.[91] Other side effects of cannabis use include cannabinoid hyperemesis syndrome.[92]
A number of people who have used cannabis to fight cancer, have later died of the cancer. I’m concerned that what may have killed many of these people, is that a minor change in the growing conditions of the cannabis plants, reduced the potency of whichever ingredients have the anti-cancer effect. The people kept dosing themselves with their oils or tinctures, but the oils and tinctures no longer contained enough cancer-fighting agents to defeat the cancer, and the people had no way of measuring this.
Apart from Endoca CBD oils, you will also find other similar products, such as isolate, tinctures or creams. Some products are designed for pets too. The range offered by Endoca is not impressive when compared to more prestigious manufacturers, but you can still find anything you might need. Using in house green equipment and procedures for the manufacturing process, Endoca can also afford to keep the prices a little lower.
Nature’s Script offers a wide range of CBD oil products. Tinctures are available in 30mL containers and 300mg, 600mg, 1000mg, 2,000mg, and 4,000mg concentrations. These products come in watermelon or peppermint flavors. Nature’s Script recommends a beginning dose of 5mg to 10mg per day, and to gradually increase the dose until the desired effects are reached. Nature’s Script also sells CBD capsules and vape juice, as well as gummies and mixing syrup for those who enjoy edibles and a pain-relief topical sold in one- and four-ounce containers. These products do not contain any THC and pose no risk for drug test takers.
Some manufacturers ship CBD products nationally, an illegal action which the FDA has not enforced in 2018, with CBD remaining the subject of an FDA investigational new drug evaluation, and is not considered legal as a dietary supplement or food ingredient as of December 2018.[70][71] Federal illegality has made it difficult historically to conduct research on CBD.[72] CBD is openly sold in head shops and health food stores in some states where such sales have not been explicitly legalized.[73][74] 

Until recent times, the cultivation of hemp primarily as an oilseed was largely unknown, except in Russia. Today, it is difficult to reconstruct the type of plant that was grown there as an oilseed, because such cultivation has essentially been abandoned. Oilseed hemp cultivars in the modern sense were not available until very recently, but some land races certainly were grown specifically for seeds in Russia. Dewey (1914) gave the following information: “The short oil-seed hemp with slender stems, about 30 inches high, bearing compact clusters of seeds and maturing in 60 to 90 days, is of little value for fiber production, but the experimental plants, grown from seed imported from Russia, indicate that it may be valuable as an oil-seed crop to be harvested and threshed in the same manner as oil-seed flax.” Most hemp oilseed in Europe is currently obtained from so-called “dual usage” plants (employed for harvest of both stem fiber and seeds, from the same plants). Of the European dual-usage cultivars, ‘Uniko B’ and ‘Fasamo’ are particularly suited to being grown as oilseeds. Very recently, cultivars have been bred specifically for oilseed production. These include ‘Finola,’ formerly known as ‘Fin-314’ (Fig. 6) and ‘Anka’ (Fig. 7), which are relatively short, little-branched, mature early in north-temperate regions, and are ideal for high-density planting and harvest with conventional equipment. Dewey (1914) noted that a Turkish narcotic type of land race called “Smyrna” was commonly used in the early 20th century in the US to produce birdseed, because (like most narcotic types of Cannabis) it is densely branched, producing many flowers, hence seeds. While oilseed land races in northern Russia would have been short, early-maturing plants in view of the short growing season, in more southern areas oilseed landraces likely had moderate height, and were spaced more widely to allow abundant branching and seed production to develop. Until Canada replaced China in 1998 as a source of imported seeds for the US, most seeds used for various purposes in the US were sterilized and imported from China. Indeed, China remains the largest producer of hempseed. We have grown Chinese hemp land races, and these were short, branched, adapted to a very long growing season (i.e. they come into flower very slowly in response to photoperiodic induction of short days in the fall), and altogether they were rather reminiscent of Dewey’s description of Smyrna. Although similar in appearance to narcotic strains of C. sativa, the Chinese land races we grew were in fact low in intoxicating constituents, and it may well be that what Dewey thought was a narcotic strain was not. Although some forms of C. sativa have quite large seeds, until recently oilseed forms appear to have been mainly selected for a heavy yield of seeds, usually recognizable by abundant branching. Such forms are typically grown at lower densities than hemp grown only for fiber, as this promotes branching, although it should be understood that the genetic propensity for branching has been selected. Percentage or quality of oil in the seeds does not appear to have been important in the past, although selection for these traits is now being conducted. Most significantly, modern selection is occurring with regard to mechanized harvesting, particularly the ability to grow in high density as single-headed stalks with very short branches bearing considerable seed.
^ World Health Organization.Constitution of the World Health Organization as adopted by the International Health Conference, New York, 19–22 June 1946; signed on 22 July 1946 by the representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and entered into force on 7 April 1948. In Grad, Frank P. (2002). "The Preamble of the Constitution of the World Health Organization". Bulletin of the World Health Organization. 80 (12): 982.

With so many companies popping up every day, we’ve done the hard work for you. We bring you the best CBD oil guide and the top 25 brands that made our list based on CBD oil quality, effectiveness, customer service and of course price. Please note, this article is updated constantly, so don’t forget come back from time to time to see the most updated information.
A rather thorough analysis of the scope of the illicit marijuana industry in Canada for 1998 is reported at www.rcmp-grc.gc.ca/html/drugsituation.htm#Marihuana and summarized in MacLeod (1999). At least 800 tonnes (t) of marijuana were grown in Canada in 1998, representing a harvest of 4.7 million flowering plants. More than 50% of the marijuana available in Canada is grown domestically. An average mature plant was estimated to produce 170 g of “marketable substance.” The value of the Canadian crop is uncertain, but has been estimated to be in the billions of dollars annually (Heading 1998; MacLeod 1999).

The 2018 Farm Bill will radically overhaul America’s relation to hemp and could unleash a hemp renaissance in the coming years that will close the gap between the U.S. and China. As a Schedule 1 substance alongside marijuana, hemp farmers and entrepreneurs in the U.S. have faced many barriers to doing business. Interstate commerce for hemp products was almost non-existent and financing was difficult to come by. But all that is set to change.
About 9% of those who experiment with marijuana eventually become dependent according to DSM-IV (1994) criteria.[78] A 2013 review estimates daily use is associated with a 10-20% rate of dependence.[42] The highest risk of cannabis dependence is found in those with a history of poor academic achievement, deviant behavior in childhood and adolescence, rebelliousness, poor parental relationships, or a parental history of drug and alcohol problems.[138] Of daily users, about 50% experience withdrawal upon cessation of use (i.e. are dependent), characterized by sleep problems, irritability, dysphoria, and craving.[117] Cannabis withdrawal is less severe than withdrawal from alcohol.[139] 

Topicals represent a newer emerging market in medical marijuana products geared toward health and beauty. Cannabinoids can be absorbed through the skin for certain therapeutic benefits without any psychoactivity. Additionally, the essential oils in hemp and cannabis provide many benefits for skin health. From moisturizers to shampoos and deodorants, medical cannabis products continue to diversify.
Other “minor phytocannabinoids” in cannabis may also contribute relevant activity (McPartland and Russo 2001). Cannabichromene (CBC) is the third most prevalent cannabinoid in cannabis, and is also anti-inflammatory (Wirth et al 1980), and analgesic, if weaker than THC (Davis and Hatoum 1983). Cannabigerol (CBG) displays sub-micromolar affinity for CB1 and CB2 (Gauson et al 2007). It also exhibits GABA uptake inhibition to a greater extent than THC or CBD (Banerjee et al 1975), suggesting possible utilization as a muscle relaxant in spasticity. Furthermore, CBG has more potent analgesic, anti-erythema and lipooxygenase blocking activity than THC (Evans 1991), mechanisms that merit further investigation. It requires emphasis that drug stains of North American (ElSohly et al 2000; Mehmedic et al 2005), and European (King et al 2005) cannabis display relatively high concentrations of THC, but are virtually lacking in CBD or other phytocannabinoid content.
Fig. 2. Cannabis sativa. This superb composite plate by artist Elmer Smith, often reproduced at a very small scale and without explanation in marijuana books, is the best scientific illustration of the hemp plant ever prepared. 1. Flowering branch of male plant. 2. Flowering branch of female plant. 3. Seedling. 4. Leaflet. 5. Cluster of male flowers. 6. Female flower, enclosed by perigonal bract. 7. Mature fruit enclosed in perigonal bract. 8. Seed (achene), showing wide face. 9. Seed, showing narrow face. 10. Stalked secretory gland. 11. Top of sessile secretory gland. 12. Long section of cystolith hair (note calcium carbonate concretion at base). Reproduced with the permission of Harvard University, Cambridge, MA.

There has been little high-quality research into the use of cannabidiol for epilepsy, and what there is is limited to refractory epilepsy in children.[16] While the results of using medical-grade cannabidiol in combination with conventional medication shows some promise, they did not lead to seizures being eliminated, and were associated with some minor adverse effects.[16]

Hemp rope was used in the age of sailing ships, though the rope had to be protected by tarring, since hemp rope has a propensity for breaking from rot, as the capillary effect of the rope-woven fibers tended to hold liquid at the interior, while seeming dry from the outside.[44] Tarring was a labor-intensive process, and earned sailors the nickname "Jack Tar". Hemp rope was phased out when manila rope, which does not require tarring, became widely available. Manila is sometimes referred to as Manila hemp, but is not related to hemp; it is abacá, a species of banana.
American Shaman CBD oil capsules is potent and speedy in relieving pain. It is among the strongest CBD products on the market due to the high concentrations of CBD. In terms of concentration, it is one of the front runners. The manufacturer is not new at all, so it does not belong to this modern trend of CBD , but its products dominate the market for years. Overtime, it has developed a solid reputation based on quality.
I was in awe of CBD's potent effects, especially when I learned that the oil could be used to treat everyday ailments like anxiety, chronic pain, migraines, nausea, and inflammation in addition to serious issues like epilepsy, cancer, multiple sclerosis, and Parkinson's. With that, I threw caution to the wind and asked for a sample. Here's what happened when I took one full dropper of Charlotte's Web's Everyday Plus Hemp Oil in the mint chocolate flavor every morning for seven days.
I have neuropathic pain. I’ve tried 3 brands now, this last one being less expensive. I “think” it’s helping a little bit…. maybe it’s wishful thinking. I never really knew how much to take. There is so much confusion on dosing, so I just take a dropper full now. Maybe that’s too much, maybe not. Should I take it twice a day, or once? I find it very hard to compare brand to brand. Thank you for your detailed, informative article. If anyone would care to share how much oil they take daily, I would appreciate it. I’m just trying to get a rough idea of what’s normal, an average. thanks.

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"From the colonial period through the middle of the nineteenth century, hemp was widely grown in the United States for use in fabric, twine, and paper.19 Production dropped by the 1890’s as technological advances made cotton a more competitive textile crop, and coarse fiber crops were increasingly imported.20 Nonetheless, American farmers continued to grow hemp into the middle of the twentieth century, finding it a useful rotation crop because it acted as a natural herbicide21—a dense, rapidly growing crop, it choked out weeds prior to the next planting of corn and other crops.22 At the urging of the government, production to supply fiber for military purposes was expanded enormously during World War I and again during World War II, particularly after the Japanese cut off exports from the Philippines."
Personal health depends partially on the active, passive, and assisted cues people observe and adopt about their own health. These include personal actions for preventing or minimizing the effects of a disease, usually a chronic condition, through integrative care. They also include personal hygiene practices to prevent infection and illness, such as bathing and washing hands with soap; brushing and flossing teeth; storing, preparing and handling food safely; and many others. The information gleaned from personal observations of daily living – such as about sleep patterns, exercise behavior, nutritional intake and environmental features – may be used to inform personal decisions and actions (e.g., "I feel tired in the morning so I am going to try sleeping on a different pillow"), as well as clinical decisions and treatment plans (e.g., a patient who notices his or her shoes are tighter than usual may be having exacerbation of left-sided heart failure, and may require diuretic medication to reduce fluid overload).[57]
Over decades, researchers have found that THC may help treat pain, nausea, loss of appetite and other problems, while CBD was thought to be biologically inactive in humans. But in the past 10 years, scientists have concluded that CBD may be quite useful. Dozens of studies have found evidence that the compound can treat epilepsy as well as a range of other illnesses, including anxiety, schizophrenia, heart disease and cancer.
With marijuana, apparently, we’re still waiting for this information. It’s hard to study a substance that until very recently has been almost universally illegal. And the few studies we do have were done mostly in the nineteen-eighties and nineties, when cannabis was not nearly as potent as it is now. Because of recent developments in plant breeding and growing techniques, the typical concentration of THC, the psychoactive ingredient in marijuana, has gone from the low single digits to more than twenty per cent—from a swig of near-beer to a tequila shot.
Hemp, grown under license mostly in Canada, is the most publicized “new” crop in North America. Until very recently the prohibition against drug forms of the plant prevented consideration of cultivation of fiber and oilseed cultivars in Canada. However, in the last 10 years three key developments occurred: (1) much-publicized recent advances in the legal cultivation of hemp in western Europe, especially for new value-added products; (2) enterprising farmers and farm groups became convinced of the agricultural potential of hemp in Canada, and obtained permits to conduct experimental cultivation; and (3) lobby groups convinced the government of Canada that narcotic forms of the hemp plant are distinct and distinguishable from fiber and oilseed forms. In March 1998, new regulations (under the Controlled Drugs and Substances Act) were provided to allow the commercial development of a hemp industry in Canada, and since then more than a thousand licenses have been issued. Hectares licensed for cultivation for 1998–2001 were respectively, 2,500, 14,200, 5,487, and 1,355, the decreasing trend due to a glut of seed produced in 1999 and pessimism over new potential regulations barring exports to the US. Information on the commercial potential of hemp in Canada is in Blade (1998), Marcus (1998), and Pinfold Consulting (1998). In the US, a substantial trade in hemp products has developed, based on imports of hemp fiber, grain, and oil. The American agricultural community has observed this, and has had success at the state level in persuading legislators of the advisability of experimental hemp cultivation as a means of evaluating the wisdom of re-establishing American hemp production. However, because of opposition by the federal government, to date there has only been a small experimental plot in Hawaii. Information on the commercial potential of hemp in the US is presented in the following.
Put simply, “indica” strains are those associated with a strong body-high, feelings of sedation and relaxation. For this reason, indicas are often thought of as the “heavier” strains of cannabis, offering stronger highs that impact the whole body. They’re popular among marijuana users as pain relieving and sleep-inducing strains. Indicas are especially popular among medical cannabis patients.
Despite the fact that Cannabis was grown on a large scale in many countries, the abuse as a narcotic remained uncommon in Western countries until relatively recently. People were largely unaware of the psychoactive properties of Cannabis and it is unlikely that early cultivars, selected mainly for their seed or fiber qualities, contained significant amounts of the psychoactive THC. The medicinal use of Cannabis was introduced in Europe only around 1840, by a young Irish doctor, William O’Shaughnessy, who served for the East India Trading Company in India, where the medicinal use of Cannabis was widespread. Unlike the European fiber Cannabis, these Indian varieties did contain a reasonable amount of bioactive cannabinoids. In the following decades, the medicinal use of Cannabis saw a short period of popularity both in Europe and in the United States. At the top of its popularity, more than 28 different medicinal preparations were available with Cannabis as active ingredient, which were recommended for indications as various as menstrual cramps, asthma, cough, insomnia, support of birth labor, migraine, throat infection, and withdrawal from opium use.27 

My daughter was in a car accident and she is in bad pain. She had a stomach hernia from a liver operation & the airbags hurt the hernia. She had the nerves burned on one side of her stomach but it didn’t do any good. Now tomorrow she is having the other side done. her accident was over a month ago. I told her to go to a pain management doctor so she could get help. Then I saw this post & sent it to her. She wants to know if it takes time to work – it so how long. Also would it mix with other meds? Thanks for your response.
The market is rife with misinformation even when CBD is sold as a relatively simple oil or supplement. When it’s squirted into a latte or baked into a cookie, CBD’s uses and effects get even more opaque. The chemical’s loudest advocates make health claims far beyond the current scientific evidence, and its harshest critics often dismiss the compound entirely as just another snake oil in America’s long tradition of health scams. Journalists are starting to get a handle on what CBD actually does and what is actually known about it, but along with researchers and regulators, we’re still playing catch-up when it comes to the people who have pushed the compound into what feels like mainstream overnight success: entrepreneurs.
PTSD. My husband suffers chronic PTSD from active military service. We live not far from a large Army base and though my husband served with another counties military we hear stories constantly of family breakdowns over PTSD. It’s not a easy path but I’m hoping one day to find something to stop the endless trips to the psych ward. It’s just not right that those who serve come home to no government help.
In 1988, the first cannabinoid receptor was identified (CB1) (Howlett et al 1988) and in 1993, a second was described (CB2) (Munro et al 1993). Both are 7-domain G-protein coupled receptors affecting cyclic-AMP, but CB1 is more pervasive throughout the body, with particular predilection to nociceptive areas of the central nervous system and spinal cord (Herkenham et al 1990; Hohmann et al 1999), as well as the peripheral nervous system (Fox et al 2001; Dogrul et al 2003) wherein synergy of activity between peripheral and central cannabinoid receptor function has been demonstrated (Dogrul et al 2003). CB2, while commonly reported as confined to lymphoid and immune tissues, is also proving to be an important mediator for suppressing both pain and inflammatory processes (Mackie 2006). Following the description of cannabinoid receptors, endogenous ligands for these were discovered: anandamide (arachidonylethanolamide, AEA) in 1992 in porcine brain (Devane et al 1992), and 2-arachidonylglycerol (2-AG) in 1995 in canine gut tissue (Mechoulam et al 1995) (Figure 1). These endocannabinoids both act as retrograde messengers on G-protein coupled receptors, are synthesized on demand, and are especially active on glutamatergic and GABA-ergic synapses. Together, the cannabinoid receptors, their endogenous ligands (“endocannabinoids”) and metabolizing enzymes comprise the endocannabinoid system (ECS) (Di Marzo et al 1998), whose functions have been prosaically termed to be “relax, eat, sleep, forget and protect” (p. 528). The endocannabinoid system parallels and interacts at many points with the other major endogenous pain control systems: endorphin/enkephalin, vanilloid/transient receptor potential (TRPV), and inflammatory. Interestingly, our first knowledge of each pain system has derived from investigation of natural origin analgesic plants, respectively: cannabis (Cannabis sativa, C. indica) (THC, CBD and others), opium poppy (Papaver somniferun) (morphine, codeine), chile peppers (eg, Capsicum annuum, C. frutescens, C. chinense) (capsaicin) and willow bark (Salix spp.) (salicylic acid, leading to acetylsalicylic acid, or aspirin). Interestingly, THC along with AEA and 2-AG, are all partial agonists at the CB1 receptor. Notably, no endocannabinoid has ever been administered to humans, possibly due to issues of patentability and lack of commercial feasibility (Raphael Mechoulam, pers comm 2007). For an excellent comprehensive review of the endocannabinoid system, see Pacher et al (2006), while Walker and Huang have provided a key review of antinociceptive effects of cannabinoids in models of acute and persistent pain (Walker and Huang 2002).
Wikidata: Q79817 Wikispecies: Cannabis APDB: 189080 APNI: 106875 BioLib: 3465 EoL: 72695 EPPO: 1CNIG FloraBase: 22595 FNA: 105522 FoC: 105522 GBIF: 2984538 GRIN: 2034 iNaturalist: 72032 IPNI: 40737-1 IRMNG: 1280947 ITIS: 19108 NBN: NHMSYS0000456774 NCBI: 3482 NZOR: 5344e3b5-4049-474a-ac38-eb23ffc8f216 PLANTS: CANNA POWO: urn:lsid:ipni.org:names:30204649-2 Tropicos: 40000735 uBio: 4894539 VASCAN: 945
Hemp is possibly one of the earliest plants to be cultivated.[109][110] An archeological site in the Oki Islands near Japan contained cannabis achenes from about 8000 BC, probably signifying use of the plant.[111] Hemp use archaeologically dates back to the Neolithic Age in China, with hemp fiber imprints found on Yangshao culture pottery dating from the 5th millennium BC.[108][112] The Chinese later used hemp to make clothes, shoes, ropes, and an early form of paper.[108] The classical Greek historian Herodotus (ca. 480 BC) reported that the inhabitants of Scythia would often inhale the vapors of hemp-seed smoke, both as ritual and for their own pleasurable recreation.[113]
Thirty minutes later, I was surprised by how subtle the effect was. While I expected a hazy nodding-off effect similar to melatonin's, the oil simply relaxed my body ever so slightly—my heart stopped pounding against my chest, my legs stopped kicking beneath my sheets, my mind stopped racing. I wasn't sure if it was the oil or the late hour, but eventually, physical relaxation gave way to mental relaxation, and I drifted off to sleep.

Although THC is best known for its mind-altering euphoria, it too has important medical benefits. There’s some overlap in what CBD and THC can treat, but THC is particularly effective in relieving nausea, appetite loss, insomnia, among other symptoms. Many patients find that a balance of CBD and THC offers the best symptom relief as the two work together synergistically.
Hemp plants are almost always cultivated outdoors, as opposed to marijuana plants, which are mostly planted in greenhouse or indoor settings. Because hemp is susceptible to the same predators diseases and insects that attack marijuana, the hemp industry employs a technique called crop rotation, in which alternating crops are planted in the same place, to avoid any buildup of these organisms and allow nutrients to return to the soil. The specific order of crop rotation and types of crops being rotated with hemp will depend on the location of the farm. Hemp is also used as a rotational crop at farms where it is not the primary agricultural product.
Reflecting the next morning, I was most surprised by the fact that I never felt "high" in any way—there was never a moment of It's kicking in; I can feel it now like with pain medications or even anti-anxiety drugs. Considering it takes time, consistency, and the right dosage to experience the full effect, I continued taking the oil once a day for the next six days. Here's what went down.
Today, you’ll find nutty-tasting (hull-less) hemp seeds and their oils baked in breads, cookies, and cakes, blended in smoothies, or tossed into quinoa and pasta dishes, burgers, pizza, vegetables sautés, soups, salads, oatmeal, yogurt, trail mix, and salad dressings. It’s a niche market, with a growing number of specialty outlets due to a growing understanding of this food’s nutritional benefits.
Hemp is a farmer's friend because compared with cotton, corn, and soybeans, it requires little water, isn't picky when it comes to poor soil. It grows tightly spaced, thus crowding out weeds, and boasts a deep, soil-aerating root system. Despite all its advantages, and because growing it is illegal with the exception of limited licenses, the U.S. imports approximately $60 million worth of hemp from overseas countries like China.

But before you do that, know that all hemp CBD oils are not created equal! A recent study published in the Journal of the American Medical Association found nearly 70 percent of hemp CBD oil sold online was mislabeled. During the Penn Medicine study, researchers analyzed 84 products purchased from 31 companies. Around 42 percent of products were under-labeled, meaning the product contained more CBD than labeled. Twenty-six percent of products contained less CBD than indicated on packaging.
The nutrition and supplement industry—which includes CBD products—is almost wholly unregulated. “The concentrations in products are only approximate, and I don’t know how well they’re tracked,” Szaflarski says. Even if you could absolutely trust a product’s label—and many CBD manufacturers, aware of the current scrutiny on their industry, go to great lengths to assure consumers of the quality of their products—there aren’t a lot of concrete facts when it comes to the type or amount of CBD a person should take for a specific ailment or aim.
A mixture of fiberglass, hemp fiber, kenaf, and flax has been used since 2002 to make composite panels for automobiles.[37] The choice of which bast fiber to use is primarily based on cost and availability. Various car makers are beginning to use hemp in their cars, including Audi, BMW, Ford, GM, Chrysler, Honda, Iveco, Lotus, Mercedes, Mitsubishi, Porsche, Saturn, Volkswagen[38] and Volvo. For example, the Lotus Eco Elise[39] and the Mercedes C-Class both contain hemp (up to 20 kg in each car in the case of the latter).[40]
To my understanding, neither CBD nor THC are effective for “severe” pain; rather, they work better for mild to moderate chronic pain. Often, with severe pain, the dosage of opiates can be decreased with concomitant use of medical cannabis or CBD and that decrease in dose makes their use safer. Concurrent use of THC does increase the analgesic effect of CBD, but it also adds the “high” which some people do not want as a side effect.
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