^ Jump up to: a b c Whiting, PF; Wolff, RF; Deshpande, S; Di Nisio, M; Duffy, S; Hernandez, AV; Keurentjes, JC; Lang, S; Misso, K; Ryder, S; Schmidlkofer, S; Westwood, M; Kleijnen, J (23 June 2015). "Cannabinoids for Medical Use: A Systematic Review and Meta-analysis" (PDF). JAMA. 313 (24): 2456–2473. doi:10.1001/jama.2015.6358. hdl:10757/558499. PMID 26103030.
Cannabinoids are divided into three groups. The first are naturally occurring 21-carbon terpenophenolic compounds found to date solely in plants of the Cannabis genus, currently termed phytocannabinoids (Pate 1994). The best known analgesic of these is Δ9-tetrahydrocannabinol (henceforth, THC)(Figure 1), first isolated and synthesized in 1964 (Gaoni and Mechoulam 1964). In plant preparations and whole extracts, its activity is complemented by other “minor” phytocannabinoids such as cannabidiol (CBD) (Figure 1), cannabis terpenoids and flavonoids, as will be discussed subsequently.
I am currently going through red skin syndrome/topical steroid withdrawal. The only cure as of now is time(6 months to 3 years) and waiting out horrible eczema-like flares. My main issue is burning/tingling skin that is almost constant. Steroids close off blood vessels and when you stop them they 'wake' up causing this nerve discomfort/pain. I've been smoking medical cannabis for the duration of my recovery(1.5 years) and It's done wonders except that the flare is around my mouth and I'm afraid the smoking is causing more issues.. as well as helping. I need to step up my game and take a different approach. I am wondering how to go about using cbd but I don't know where to start and was wondering if you could help. Thank you
Cannabis use is associated with increased recruitment of task-related areas, such as the dorsolateral prefrontal cortex, which is thought to reflect compensatory activity due to reduced processing efficiency.[114][113][116] Cannabis use is also associated with downregulation of CB1 receptors. The magnitude of down regulation is associated with cumulative cannabis exposure, and is reversed after one month of abstinence.[117][118][119] There is limited evidence that chronic cannabis use can reduce levels of glutamate metabolites in the human brain.[120]
The overall effect is not assured because, like cannabis — which is illegal under U.S. federal law although some states have allowed medical or recreational use — states will continue to be able to enact laws related to industrial hemp, allowing for a potential patchwork of legislation across the country. Other questions remain in terms of how exactly the Agriculture Department will regulate the plant.
Fig. 6. ‘Finola,’ the first cultivar of Cannabis sativa bred exclusively for grain. (Courtesy of the breeder, J.C. Callaway, Univ. Kuopio, Finland.) Fig. 7. ‘Anka,’ the first registered North American bred cultivar of Cannabis sativa. This variety is best suited for grain production. (Courtesy of the breeder, P. Dragla, and of the Industrial Hemp Seed Development Company, Chatham, Ontario.)
Hemp isn’t completely absent of psychoactive compounds, but that doesn’t mean it will get you high. Hemp plants simply don’t produce enough THC to have an intoxicating effect. CBD, though psychoactive, is a non-intoxicating cannabinoid and won’t produce any form of a euphoric high on its own. In other words, hemp has plenty of therapeutic potential, but you’ll have to look elsewhere if you want to get high.

Drug policy is always clearest at the fringes. Illegal opioids are at one end. They are dangerous. Manufacturers and distributors belong in prison, and users belong in drug-treatment programs. The cannabis industry would have us believe that its product, like coffee, belongs at the other end of the continuum. “Flow Kana partners with independent multi-generational farmers who cultivate under full sun, sustainably, and in small batches,” the promotional literature for one California cannabis brand reads. “Using only organic methods, these stewards of the land have spent their lives balancing a unique and harmonious relationship between the farm, the genetics and the terroir.” But cannabis is not coffee. It’s somewhere in the middle. The experience of most users is relatively benign and predictable; the experience of a few, at the margins, is not. Products or behaviors that have that kind of muddled risk profile are confusing, because it is very difficult for those in the benign middle to appreciate the experiences of those at the statistical tails. Low-frequency risks also take longer and are far harder to quantify, and the lesson of “Tell Your Children” and the National Academy report is that we aren’t yet in a position to do so. For the moment, cannabis probably belongs in the category of substances that society permits but simultaneously discourages. Cigarettes are heavily taxed, and smoking is prohibited in most workplaces and public spaces. Alcohol can’t be sold without a license and is kept out of the hands of children. Prescription drugs have rules about dosages, labels that describe their risks, and policies that govern their availability. The advice that seasoned potheads sometimes give new users—“start low and go slow”—is probably good advice for society as a whole, at least until we better understand what we are dealing with.


^ Housman & Dorman 2005, pp. 303–04. "The linear model supported previous findings, including regular exercise, limited alcohol consumption, abstinence from smoking, sleeping 7–8 hours a night, and maintenance of a healthy weight play an important role in promoting longevity and delaying illness and death." Citing Wingard DL, Berkman LF, Brand RJ (1982). "A multivariate analysis of health-related practices: a nine-year mortality follow-up of the Alameda County Study". Am J Epidemiol. 116 (5): 765–75. doi:10.1093/oxfordjournals.aje.a113466. PMID 7148802.
This article will attempt to present information concerning cannabinoid mechanisms of analgesia, review randomized clinical trials (RCTs) of available and emerging cannabinoid agents, and address the many thorny issues that have arisen with clinical usage of herbal cannabis itself (“medical marijuana”). An effort will be made to place the issues in context and suggest rational approaches that may mitigate concerns and indicate how standardized pharmaceutical cannabinoids may offer a welcome addition to the pharmacotherapeutic armamentarium in chronic pain treatment.

All that's changed with the high trade tariffs Trump's levied on countries who import our products. Analysts and existing evidence suggest the soybean trade conflicts will be in favor of fellow exporters, Brazil and Argentina, rather than the U.S. The tariff could drop China’s imports of soybeans by 69% on average. The estimated effect of China’s 25% tariff on U.S. soybean imports would cut income for a midsize Illinois grain farm by an average of 87% over four years, prompting a loss of more than $500,000 in the farm’s net worth by 2021.
Hearst and Rockefeller did not want Hemp or any form of Cannabis interfering with their lucrative paper, pharmaceutical and oil industries. Hemp is versatile and renewable. It can be used for food, medicine, fuel, paper, clothing, plastic, building materials; just about anything paper and oil is used for. These bastard wealthy people have done a disservice to all people and for the sake of lining their already copiously rich pockets. They and those like them are criminals of the worst order

The first of Berenson’s questions concerns what has long been the most worrisome point about cannabis: its association with mental illness. Many people with serious psychiatric illness smoke lots of pot. The marijuana lobby typically responds to this fact by saying that pot-smoking is a response to mental illness, not the cause of it—that people with psychiatric issues use marijuana to self-medicate. That is only partly true. In some cases, heavy cannabis use does seem to cause mental illness. As the National Academy panel declared, in one of its few unequivocal conclusions, “Cannabis use is likely to increase the risk of developing schizophrenia and other psychoses; the higher the use, the greater the risk.”

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