This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Tetrahydrocannabinol (THC, Marinol®) and nabilone (Cesamet®) are currently approved in the United States and other countries, but not for pain indications. Other synthetic cannabinoids, such as ajulemic acid, are in development. Crude herbal cannabis remains illegal in most jurisdictions but is also under investigation. Sativex®, a cannabis derived oromucosal spray containing equal proportions of THC (partial CB1 receptor agonist ) and cannabidiol (CBD, a non-euphoriant, anti-inflammatory analgesic with CB1 receptor antagonist and endocannabinoid modulating effects) was approved in Canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain. An Investigational New Drug application to conduct advanced clinical trials for cancer pain was approved by the US FDA in January 2006. Cannabinoid analgesics have generally been well tolerated in clinical trials with acceptable adverse event profiles. Their adjunctive addition to the pharmacological armamentarium for treatment of pain shows great promise.
The earliest recorded uses date from the 3rd millennium BC.[32] Since the early 20th century, cannabis has been subject to legal restrictions. The possession, use, and sale of cannabis is illegal in most countries of the world.[33][34] Medical cannabis refers to the physician-recommended use of cannabis, which takes place in Canada, Belgium, Australia, the Netherlands, Germany, Spain, and 33 U.S. states.[35][36] In September 2018, cannabis was legalized in South Africa[37] while Canada legalized recreational use of cannabis in October 2018.[38]
CBD is a 5-HT1A receptor agonist, which may also contribute to an anxiolytic effect.[156] This likely means the high concentrations of CBD found in Cannabis indica mitigate the anxiogenic effect of THC significantly.[156] The cannabis industry claims that sativa strains provide a more stimulating psychoactive high while indica strains are more sedating with a body high.[157] However this is disputed by researchers.[158]
A number of people who have used cannabis to fight cancer, have later died of the cancer. I’m concerned that what may have killed many of these people, is that a minor change in the growing conditions of the cannabis plants, reduced the potency of whichever ingredients have the anti-cancer effect. The people kept dosing themselves with their oils or tinctures, but the oils and tinctures no longer contained enough cancer-fighting agents to defeat the cancer, and the people had no way of measuring this.
The use of cannabis for pain relief dates back to ancient China, according to a report published in the journal Cannabis and Cannabinoid Research. It’s thought that CBD oil might help ease chronic pain in part by reducing inflammation. In addition, CBD oil is said to promote sounder sleep and, in turn, treat sleep disruption commonly experienced by people with chronic pain.
Based on reviews, smoking or vaporizing CBD vape oil seems to have less effects when compared to other methods of administering CBD, such as tinctures, capsules and sprays. On the flip side, others argue that smoking or vaporizing has less drawbacks than taking CBD orally, since ingesting CBD orally could result in inconsistent absorption and a delayed effect.

Mainly what they look for in drug test is THC. Hemp contains only very minuscule amounts of THC. You cannot get high off of hemp. It is impossible. You would have to smoke or eat a boat load of hemp to even remotely get a buzz. A person could not ingest that much hemp, and a person would die of smoke inhalation before smoking enough to achieve a buzz. So hemp does not contain enough THC to show up on a drug screening. I hope this information helps you.

"Hemp fields, in fact, could be a deterrent to marijuana growers. A strong case can be made that the best way to reduce the THC level of marijuana grown outdoors would be to grow industrial hemp near it. An experiment in Russia found that hemp pollen could travel 12 kilometers. This would mean that a hemp field would create a zone with a 12-kilometer radius within which no marijuana grower would want to establish a crop.


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In the early 1990s, industrial hemp agriculture in North America began with the Hemp Awareness Committee at the University of Manitoba. The Committee worked with the provincial government to get research and development assistance, and was able to obtain test plot permits from the Canadian government. Their efforts led to the legalization of industrial hemp (hemp with only minute amounts of tetrahydrocannabinol) in Canada and the first harvest in 1998.[82][83]
I recently was a guest at a medical marijuana educational event that highlighted the work of researcher Michael Backes. During his presentation he made a statement about CBD that I have never heard anywhere else that CBD is “regulating” (my word) the effects of THC. I asked the Nurse Practitioner at the event, Ivy Lou Hibbitt of Certicann.com, what he meant by that and she said it was her understanding of Michael’s comment that he takes CBD to reduce the psychoactive effects of THC. Has this property of CBD, that it can lessen psychoactive effects, ever been researched elsewhere?
The Marinol patient monograph cautions that patients should not drive, operate machinery or engage in hazardous activities until accustomed to the drug’s effects (http://www.solvaypharmaceuticals-us.com/static/wma/pdf/1/3/1/9/Marinol5000124ERev52003.pdf). The Sativex product monograph in Canada (http://www.bayerhealth.ca/display.cfm?Object_ID=272&Article_ID=121&expandMenu_ID=53&prevSubItem=5_52) suggests that patients taking it should not drive automobiles. Given that THC is the most active component affecting such abilities, and the low serum levels produced in Sativex therapy (vide supra), it would be logical that that patients may be able to safely engage in such activities after early dose titration and according to individual circumstances, much as suggested for oral dronabinol. This is particularly the case in view of a report by an expert panel (Grotenhermen et al 2005) that comprehensively analyzed cannabinoids and driving. It suggested scientific standards such as roadside sobriety tests, and THC serum levels of 7–10 ng/mL or less, as reasonable approaches to determine relative impairment. No studies have demonstrated significant problems in relation to cannabis affecting driving skills at plasma levels below 5 ng/mL of THC. Prior studies document that 4 rapid oromucosal sprays of Sativex (greater than the average single dose employed in therapy) produced serum levels well below this threshold (Russo 2006b). Sativex is now well established as a cannabinoid agent with minimal psychotropic effect.
A study by Henquet and colleagues (2004) substantially replicated both the Swedish and Dutch studies in a 4-year follow-up of a cohort of 2437 adolescents and young adults between 1995 and 1999 in Munich. They found a dose–response relationship between self-reported cannabis use at baseline and the likelihood of reporting psychotic symptoms. As in the Dutch cohort, young people who reported psychotic symptoms at baseline were much more likely to experience psychotic symptoms at follow-up if they used cannabis than were cannabis-using peers without such a history.
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
Smaller companies focused on CBD beverages, such as New Age Beverages Corp. NBEV, -1.47%  , have been targeted by investors, but some firms have used CBD-related announcements to pump stock prices as well as fuel excitement in a compound that scientists do not fully understand. Other companies operating in the sector will benefit too: Charlotte’s Web Holdings Inc. CWBHF, +5.11% has focused on a range of CBD products, capturing about 17% market share in 2017 with sales in 3,000 retail locations, according to PI Financial research.
Henry Ford recognized the utility of hemp in early times. In advance of today’s automobile manufacturers, he constructed a car with certain components made of resin stiffened with hemp fiber (Fig. 19). Rather ironically in view of today’s parallel situation, Henry Ford’s hemp innovations in the 1920s occurred at a time of crisis for American farms, later to intensify with the depression. The need to produce new industrial markets for farm products led to a broad movement for scientific research in agriculture that came to be labeled “Farm Chemurgy,” that today is embodied in chemical applications of crop constituents.
Hemp can be used as a "mop crop" to clear impurities out of wastewater, such as sewage effluent, excessive phosphorus from chicken litter, or other unwanted substances or chemicals. Additionally, hemp is being used to clean contaminants at the Chernobyl nuclear disaster site, by way of a process which is known as phytoremediation—the process of clearing radioisotopes and a variety of other toxins from the soil, water, and air.[46]

Cannabidiol—more commonly abbreviated as CBD—isn’t psychoactive and, apparently to the man’s disappointment, won’t get you high. Instead, many people report that consuming it makes them feel less anxious, helps them sleep, or eases joint pain. Over the past two years, CBD in the form of oils and supplements has become widely distributed across the United States, even in places with no level of cannabis legalization. Now the trend’s new frontier is food. My first clue that it had hit some kind of critical mass was seeing a local restaurant put a sign out front announcing the debut of CBD empanadas. From design-oriented Instagram seltzer to your local pizza place, brands and restaurants want you to order some CBD and eat your feelings.

Can cannabis help treat psoriasis? The active cannabinoids in cannabis may be an effective treatment for psoriasis. Research shows that they offer potential health benefits that could relieve the symptoms of psoriasis. They may be able to reduce inflammation and itching, control pain, and even heal wounds. Learn more about cannabis for psoriasis here. Read now

Focusing more on lifestyle issues and their relationships with functional health, data from the Alameda County Study suggested that people can improve their health via exercise, enough sleep, maintaining a healthy body weight, limiting alcohol use, and avoiding smoking.[27] Health and illness can co-exist, as even people with multiple chronic diseases or terminal illnesses can consider themselves healthy.[28]


Since then, many different types of sex determination systems have been discovered, particularly in plants.[15] Dioecy is relatively uncommon in the plant kingdom, and a very low percentage of dioecious plant species have been determined to use the XY system. In most cases where the XY system is found it is believed to have evolved recently and independently.[31]
“The main overarching criticism we have with all CBD hemp products – even the good quality ones – is that they’re very limited,” Lee said. “They’re just basically one thing: a lot of CBD and very little of anything else. That can help some people sometimes but most people will find they need other options. There’s other cannabinoids you need – sometimes THC, sometimes THCA.
Scutching: Passing the stalks through a series of rollers to break apart the hemp fibers. During this step, the woody core is pushed out and separated from the pliable fibers. This is another step where proper drying comes into play. The sweet spot between 10% and 15% moisture is key here. If the stalks are too dry, they will be crushed into a powder. If they are too moist, they won’t break and separate properly.
The maintenance and promotion of health is achieved through different combination of physical, mental, and social well-being, together sometimes referred to as the "health triangle."[24][25] The WHO's 1986 Ottawa Charter for Health Promotion further stated that health is not just a state, but also "a resource for everyday life, not the objective of living. Health is a positive concept emphasizing social and personal resources, as well as physical capacities."[26]

This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Tetrahydrocannabinol (THC, Marinol®) and nabilone (Cesamet®) are currently approved in the United States and other countries, but not for pain indications. Other synthetic cannabinoids, such as ajulemic acid, are in development. Crude herbal cannabis remains illegal in most jurisdictions but is also under investigation. Sativex®, a cannabis derived oromucosal spray containing equal proportions of THC (partial CB1 receptor agonist ) and cannabidiol (CBD, a non-euphoriant, anti-inflammatory analgesic with CB1 receptor antagonist and endocannabinoid modulating effects) was approved in Canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain. An Investigational New Drug application to conduct advanced clinical trials for cancer pain was approved by the US FDA in January 2006. Cannabinoid analgesics have generally been well tolerated in clinical trials with acceptable adverse event profiles. Their adjunctive addition to the pharmacological armamentarium for treatment of pain shows great promise.

Cannabis terpenoids also display numerous attributes that may be germane to pain treatment (McPartland and Russo 2001). Myrcene is analgesic, and such activity, in contrast to cannabinoids, is blocked by naloxone (Rao et al 1990), suggesting an opioid-like mechanism. It also blocks inflammation via PGE-2 (Lorenzetti et al 1991). The cannabis sesquiterpenoid β-caryophyllene shows increasing promise in this regard. It is anti-inflammatory comparable to phenylbutazone via PGE-1 (Basile et al 1988), but simultaneously acts as a gastric cytoprotective (Tambe et al 1996). The analgesic attributes of β-caryophyllene are increasingly credible with the discovery that it is a selective CB2 agonist (Gertsch et al 2007), with possibly broad clinical applications. α-Pinene also inhibits PGE-1 (Gil et al 1989), while linalool displays local anesthetic effects (Re et al 2000). 

Quality is a particular concern, because cannabis plants easily soak up heavy metals from pesticides and other contaminants, Marcu says. If you are buying online, look for a company that documents how it tests its products. (If the website doesn’t indicate this, call and ask.) “Buying from a reputable manufacturer is crucial, because it matters how the plant is cultivated and processed,” Dr. Maroon says. One clue that a company is cutting corners: too low a cost. Good CBD is pricey—a bottle of high-quality capsules is sold in Cohen’s office for $140. But for many, it’s worth the money. Roth spent $60 on her tiny bottle. But when her energy returned the day she started taking CBD, she decided that was a small price to pay.
“Hemp is of high nutritional quality because it contains high amounts of unsaturated fatty acids… Linoleic acid and alpha-linolenic acid are the only two fatty acids that must be ingested and are considered essential to human health … In contrast to shorter-chain and more saturated fatty acids, these essential fatty acids do not serve as energy sources, but as raw materials for cell structure and as precursors for biosynthesis for many of the body’s regulatory biochemicals…”  
^ Parliament of the Czech Republic (1998), Explanatory Report to Act No. 112/1998 Coll., which amends the Act No. 140/1961 Coll., the Criminal Code, and the Act No. 200/1990 Coll., on misdemeanors (in Czech), Prague "Podle čl. 36 Jednotné úmluvy o omamných látkách ze dne 31. března 1961 (č. 47/1965 Sb.) se signatáři zavazují k trestnímu postihu tam uvedených forem nakládání s drogami včetně jejich držby. Návrh upouští od dosavadní beztrestnosti držby omamných a psychotropních látek a jedů pro svoji potřebu. Dosavadní beztrestnost totiž eliminuje v řadě případů možnost postihu dealerů a distributorů drog."
While research into the effects of CBD on specific conditions is important, a broader perspective on the relationship between CBD and the human body is necessary to understand how this unique compound works. Interestingly, many of the conditions that are supposedly helped by CBD have no well-understood cause, from acne to Alzheimer’s disease. However, one of the few common denominators between these conditions is the involvement of the endocannabinoid system (ECS) in their causes.
In order to manage pain, we recommend ingesting full spectrum CBD oil daily in the form of Tinctures or Gel Capsules. The ingredients in the two products are the same; the only difference between the two is the form factor and dosage – pills vs. sublingual tinctures. We suggest those suffering from any kind of pain start with 5-10mg per day of CBD. If relief is not felt at this dosage, we suggest increasing by 5-10mg until the desired effects are achieved. You’ll notice that the Gel Capsules are pre-filled and contain 25mg of CBD per pill – there is no harm in starting at 25mg CBD daily as you cannot overdose on CBD nor are there any serious side effects. These ingestible products provide sustained relief for several hours – many people find they provide relief for the whole day! The one thing to keep in mind with ingestible CBD products is the delayed onset time – it can take up to 90 minutes for the full effects of the tinctures or capsules to be felt.

“THC”—the more-famous, high-inducing compound in cannabis—“works directly on the cannabinoid system, meaning it attaches to receptors and mimics some of our own internal endocannabinoids,” says Igor Grant, a professor and chair of psychiatry at the University of California, San Diego School of Medicine. But CBD’s interaction with the endocannabinoid system is subtler. “Normally, these endocannabinoid-signaling molecules are broken down by enzymes, and one thing CBD does is interfere with the actions of those enzymes.”
Scientists in Europe and North America concluded that hemp seed is an excellent source of nutrition. Numerous anecdotal incidences cited improvements in a wide range of acute and chronic conditions such as rapid healing of skin lesions and relief from flu, inflammation, and allergies. The benefits were attributed to the presence of rich source of the EFAs linoleic and alpha-linolenic acid, and their respective biologic metabolites, GLA and stearidonic acid.9
"Hemp fields, in fact, could be a deterrent to marijuana growers. A strong case can be made that the best way to reduce the THC level of marijuana grown outdoors would be to grow industrial hemp near it. An experiment in Russia found that hemp pollen could travel 12 kilometers. This would mean that a hemp field would create a zone with a 12-kilometer radius within which no marijuana grower would want to establish a crop.

Earlier this month, the world received more indicators that the “Green Rush,” once merely on the horizon, is advancing into view with increasing velocity. It really wasn’t long ago that most portrayals of legal cannabis consumers reflected long-held clichés, reinforcing a stereotype that only a certain subset of the populace used cannabis products.

At Hemp Bombs, we’re proud to source our CBD from organic, superior-grade Industrial Hemp that is grown with sustainable methods. Hemp Bombs products contain pure CBD, which is not linked with overdose or addiction. Our CBD products contain zero traces of THC, so they are considered “CBD isolate.” Not only is CBD isolate federally legal, but it also gives you the complete confidence you will not fail a drug test from using CBD products. We manufacture all products in-house. In-house manufacturing means that we maintain complete quality control of products in one facility all the way to packaging and shipping. Hemp Bombs provides you with an apparent breakdown of what is in our CBD. Our products contain pure Cannabidiol and are all labeled with the milligram dosage. Hemp Bombs CBD is third-party lab tested to ensure you the most refined product. The search is over; Hemp Bombs Premium CBD Pain Freeze is your next stop for the ultimate pain and inflammation relief.
C.S. Lewis said “badness is only spoiled goodness.” This may be an apt quote regarding public perception. It’s true that hemp’s scientific name is the same as that other Cannabis sativa, marijuana, but its constituents are different. The three cannabis plants have three different species: Sativa, used for industrial fibers, oils, food, drugs and medicine; Indica, to induce sleep; and Ruderalis, for food production. Hemp seeds contain high amounts of essential fatty acids – more than any fish and most fish oil supplements. The oil has linoleic acid, alpha-linolenic acid, and at least 20 amino acids. Altogether, hemp supplies innumerable health benefits. After decades of misunderstanding, scientists have again been tapping the amazing potential of this versatile plant.
Cannabis sativa is an annual wind-pollinated plant, normally dioecious and dimorphic, although sometimes monoecious (mostly in several modern European fiber cultivars). Figure 2 presents the basic morphology of the species. Some special hybrids, obtained by pollinating females of dioecious lines with pollen from monoecious plants, are predominantly female (so-called “all-female,” these generally also produce some hermaphrodites and occasional males). All-female lines are productive for some purposes (e.g. they are very uniform, and with very few males to take up space they can produce considerable grain), but the hybrid seed is expensive to produce. Staminate or “male” plants tend to be 10%–15% taller and are less robust than the pistillate or “female” (note the comparatively frail male in Fig. 3). So prolific is pollen production that an isolation distance of about 5 km is usually recommended for generating pure-bred foundation seed. A “perigonal bract” subtends each female flower, and grows to envelop the fruit. While small, secretory, resin-producing glands occur on the epidermis of most of the above-ground parts of the plant, the glands are very dense and productive on the perigonal bracts, which are accordingly of central interest in marijuana varieties. The root is a laterally branched taproot, generally 30–60 cm deep, up to 2.5 m in loose soils, very near the surface and more branched in wet soils. Extensive root systems are key to the ability of hemp crops to exploit deep supplies of nutrients and water. The stems are erect, furrowed, and usually branched, with a woody interior, and may be hollow in the internodes. Although the stem is often woody, the species is frequently referred to as a herb or forb. Plants vary enormously in height depending on genetic constitution and environment (Fig. 4), but are typically 1–5 m (heights of 12 m or more in cultivation have been claimed).
The 2018 Farm Bill officially reclassifies hemp for commercial uses after decades of statutes and legal enforcement conflating hemp and marijuana, the Farm Bill distinguishes between the two by removing hemp from the Controlled Substances Act. (While the two are closely related, hemp lacks the high concentration of THC that is responsible for the high from smoking marijuana.) This would effectively move regulation and enforcement of the crop from the purview of the Drug Enforcement Agency to the U.S. Department of Agriculture.
Some immediate undesired side effects include a decrease in short-term memory, dry mouth, impaired motor skills and reddening of the eyes.[50] Aside from a subjective change in perception and mood, the most common short-term physical and neurological effects include increased heart rate, increased appetite and consumption of food, lowered blood pressure, impairment of short-term and working memory,[51][52] psychomotor coordination, and concentration.
The phytocannabinoid cannabidiol (CBD), is a non-intoxicating molecule that results from the heating, or decarboxylation, of cannabidiolic acid, or CBDA. As popular as CBD has become in both the cannabis community and mainstream consumerism, its natural precursor, CBDA, is one of 114 unique cannabinoids found in cannabis. In most cultivars, or cultivated varieties of cannabis, CBD ranks low on the expression chart; there often isn’t much. However, following a explosive discovery in 2009 — it was noted that a handful of strains are rich in CBD over THC. Droves of CBD-rich cultivars began cropping up all across the US, resulting in a marked uptick in CBD availability across the states.
There’s no definite amount that’s appropriate for everyone, but the ratio of CBD to THC will indicate how psychoactive the product is and if it’s legal in your state. The more CBD compared with THC, the less of a high, and vice versa. “Managing psychoactivity is key to successful cannabis therapy,” says Lee. “Amounts should be made clear on the label and lab-certified so people know what’s helping them and what’s not.”
CBD concentrates typically contain the strongest dosage of CBD compared to any other CBD products. It can contain up to 10 times the average CBD products. Concentrates are also convenient in that it only takes a few seconds to consume. Overall, CBD concentrates seem to be most popular among customers who are extremely busy, yet seek high potency CBD.
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Infusions: Research and opportunity have driven chefs and chemists to infuse CBD into all sorts of readily usable products, such as edibles to elixirs, sublingual sprays, capsules and even topicals. Much like concentrates, each infusion sports specific combinations or isolations of CBD, THC, and other cannabinoids, allowing users to pick and choose products that suit their exact needs. CBD topicals, for example, are incredibly effective when applied to surface-level problems like bruises, joint aches, and headaches, and have been scientifically proven to successfully combat skin-based issues including pruritus with far broader implications.
Perhaps the most prevalent use for CBD is for pain management. The reality is that pain will affect everyone at some point in his or her life, and it’s comforting to know that there is a natural remedy that can help. The use of a natural remedy is especially important for those suffering from neuropathic pain and chronic pain – or pain that lasts for more than a few months. Chronic pain affects more than 3 million people in the United States every year – and the worst part? It can’t be cured. However, it can be treated and the irony is that in the United States, the most common medical treatments are nerve blocks, steroids, and narcotics (opioids) – many of which carry significant risk of side effects and addiction. Even over the counter non-steroidal anti-inflammatory drugs (NSAIDs) like Aspirin and ibuprofen are dangerous when used regularly – hospitalizing over 100,000 people each year and killing approximately 15,000. However, dangerous narcotics and NSAIDs are not your only option for pain relief! In addition to physical therapy and self-care, you can incorporate CBD into your treatment regimen for natural, plant-based pain relief. CBD is fundamentally different than most prescribed painkillers, as it’s not addictive, non-toxic, and has very minimal (if any) side effects.
Cannabis was criminalized in various countries beginning in the 19th century. The British colonies of Mauritius banned cannabis in 1840 over concerns on its effect on Indian indentured workers;[206] the same occurred in British Singapore in 1870.[207] In the United States, the first restrictions on sale of cannabis came in 1906 (in District of Columbia).[208] It was outlawed in Jamaica (then a British colony) in 1913, in South Africa in 1922, and in the United Kingdom and New Zealand in the 1920s.[209] Canada criminalized cannabis in The Opium and Narcotic Drug Act, 1923,[210] before any reports of the use of the drug in Canada, but eventually legalized its consumption for recreational and medicinal purposes in 2018.[38]
Cannabis plants produce a unique family of terpeno-phenolic compounds called cannabinoids, some of which produce the "high" which may be experienced from consuming marijuana. There are 483 identifiable chemical constituents known to exist in the cannabis plant,[49] and at least 85 different cannabinoids have been isolated from the plant.[50] The two cannabinoids usually produced in greatest abundance are cannabidiol (CBD) and/or Δ9-tetrahydrocannabinol (THC), but only THC is psychoactive.[51] Since the early 1970s, Cannabis plants have been categorized by their chemical phenotype or "chemotype", based on the overall amount of THC produced, and on the ratio of THC to CBD.[52] Although overall cannabinoid production is influenced by environmental factors, the THC/CBD ratio is genetically determined and remains fixed throughout the life of a plant.[37] Non-drug plants produce relatively low levels of THC and high levels of CBD, while drug plants produce high levels of THC and low levels of CBD. When plants of these two chemotypes cross-pollinate, the plants in the first filial (F1) generation have an intermediate chemotype and produce intermedite amounts of CBD and THC. Female plants of this chemotype may produce enough THC to be utilized for drug production.[52][53]
Wikidata: Q79817 Wikispecies: Cannabis APDB: 189080 APNI: 106875 BioLib: 3465 EoL: 72695 EPPO: 1CNIG FloraBase: 22595 FNA: 105522 FoC: 105522 GBIF: 2984538 GRIN: 2034 iNaturalist: 72032 IPNI: 40737-1 IRMNG: 1280947 ITIS: 19108 NBN: NHMSYS0000456774 NCBI: 3482 NZOR: 5344e3b5-4049-474a-ac38-eb23ffc8f216 PLANTS: CANNA POWO: urn:lsid:ipni.org:names:30204649-2 Tropicos: 40000735 uBio: 4894539 VASCAN: 945
^ Jump up to: a b c d Boggs, Douglas L; Nguyen, Jacques D; Morgenson, Daralyn; Taffe, Michael A; Ranganathan, Mohini (6 September 2017). "Clinical and preclinical evidence for functional interactions of cannabidiol and Δ9-tetrahydrocannabinol". Neuropsychopharmacology. 43 (1): 142–154. doi:10.1038/npp.2017.209. ISSN 0893-133X. PMC 5719112. PMID 28875990. 

I work well under pressure, but being extremely busy at work has almost made me less productive—I'm constantly distracted by email, Slack, and the people around me, to the point where getting my work done becomes difficult. This week, however, I've found it easier to put my blinders on, block out all distractions (especially social distractions) and focus on one task at a time. I think this is partly related to the lessened anxiety—I feel more frazzled and off task when my anxiety is running high. It almost feels like a newfound sense of clarity and calm that enables me to focus.
The endocannabinoid system is tonically active in control of pain, as demonstrated by the ability of SR141716A (rimonabant), a CB1 antagonist, to produce hyperalgesia upon administration to mice (Richardson et al 1997). As mentioned above, the ECS is active throughout the neuraxis, including integrative functions in the periacqueductal gray (Walker et al 1999a; Walker et al 1999b), and in the ventroposterolateral nucleus of the thalamus, in which cannabinoids proved to be 10-fold more potent than morphine in wide dynamic range neurons mediating pain (Martin et al 1996). The ECS also mediates central stress-induced analgesia (Hohmann et al 2005), and is active in nociceptive spinal areas (Hohmann et al 1995; Richardson et al 1998a) including mechanisms of wind-up (Strangman and Walker 1999) and N-methyl-D-aspartate (NMDA) receptors (Richardson et al 1998b). It was recently demonstrated that cannabinoid agonists suppress the maintenance of vincristine-induced allodynia through activation of CB1 and CB2 receptors in the spinal cord (Rahn et al 2007). The ECS is also active peripherally (Richardson et al 1998c) where CB1 stimulation reduces pain, inflammation and hyperalgesia. These mechanisms were also proven to include mediation of contact dermatitis via CB1 and CB2 with benefits of THC noted systemically and locally on inflammation and itch (Karsak et al 2007). Recent experiments in mice have even suggested the paramount importance of peripheral over central CB1 receptors in nociception of pain (Agarwal et al 2007)
"Even if DEA approves a permit, production might be discouraged because of the perceived difficulties of working through DEA licensing requirements and installing the types of structures necessary to obtain a permit. Obtaining a DEA permit to produce hemp requires that the applicant demonstrate that an effective security protocol will be in place at the production site, such as security fencing around the planting area, a 24-hour monitoring system, controlled access, and possibly armed guards to prevent public access.68 DEA application requirements also include a nonrefundable fee, FBI background checks, and extensive documentation. It could also be argued that the necessary time-consuming steps involved in obtaining and operating under a DEA permit, the additional management and production costs from installing structures, and other business and regulatory requirements could ultimately limit the operation’s profitability. 

The first time I came across CBD was when I was visiting my brother in San Antonio, Texas 2 years back. The one day I had some serious back pain, My brother's neighbour suggested that I should try CBD oil for my pain as it helps his mom with her cancer pain, and directed me to SABotanicals, a local CBD store in San Antonio where I bought a 2000mg CBD oil.In the beginning, I was a sceptic, but it worked so well that I ordered three more bottles to last me for a few months. I must say that also felt relaxed but could do my work with no issues as it didn't make me high.To date, I'm still using CBD oil for my paid and came off pain medications completely.God gave us something great!

Cannabis is the most widely used illicit drug. Over 100 phytocannabinoids, as well as terpenoids, fatty acids, and other compounds with health relevance, have been found in Cannabis. The pharmacological importance of cannabinoids has been intensively studied. Multiple mechanisms of the effects of cannabinoids on the nervous system are being elucidated. Cannabinoids have anti-inflammatory, antioxidant, immunomodulatory, antimicrobial, and anticancer activities. Hemp seed oil and terpenoids have health-promoting effects. The relationship between Cannabis chemotype and genotype is being revealed by chemical and genetic analyses. Various omics platform facilitate the basic and applied studies of Cannabis plants. An expanded Cannabaceae family, which consists of six genera, is advocated. This chapter summarizes the recent research progress of phytochemistry, pharmacology, and omics of Cannabis plants.
The woody core (hurds, sometimes called shives) of hemp makes remarkably good animal bedding (Fig. 28, 29). The hurds are sometimes molded into small pellets for bedding applications (Fig. 30). Such appears to be unsurpassed for horse bedding, and also make an excellent litter for cats and other pets (Fig. 31). The hurds can absorb up to five times their weight in moisture (typically 50% higher than wood shavings), do not produce dust (following initial dust removal), and are easily composted. Hemp bedding is especially suited to horses allergic to straw. In Europe, the animal bedding market is not considered important (Karus et al. 2000), but in North America there are insufficient hemp hurds available to meet market demand.
CBD strains can be consumed just as you would THC strains. You can smoke or vaporize CBD-rich flower, eat a CBD-infused edible, swallow a CBD oil capsule, apply a CBD lotion, or use a CBD tincture sublingually. Hemp products also contain CBD, though it is a less efficient source and lacks the beneficial chemical diversity of cannabis-derived CBD products (more on that here).
Scientists in Europe and North America concluded that hemp seed is an excellent source of nutrition. Numerous anecdotal incidences cited improvements in a wide range of acute and chronic conditions such as rapid healing of skin lesions and relief from flu, inflammation, and allergies. The benefits were attributed to the presence of rich source of the EFAs linoleic and alpha-linolenic acid, and their respective biologic metabolites, GLA and stearidonic acid.9 

The nervous system’s endocannabinoid system is not well understood. But it’s thought to play a role in regulating pain, sleep, mood, memory, appetite, and other cognitive and physical processes. Because CBD is able to mimic the actions of some natural brain chemicals, its potential therapeutic benefits are wide-ranging but—at this point—nebulous. “We know that cannabidiol modulates the endocannabinoid system, but we don’t know how it works,” Szaflarski says. That said, there are theories.
With that stereotype now changing in addition to the outbreak of legal marketplaces in 33 states, we’re seeing a boom in cross-industry trends where major corporate and investment players are starting to enter the cannabis sector or at least signal willingness to do so. These trends are proving so strong that companies are starting to think it’s important to get in the game or risk being left behind later. That’s why major brands are either dipping a toe into the water or laying the groundwork for a cannonball-level splash when the Green Rush finally breaks.
^ Gobbi, Gabriella; Atkin, Tobias; Zytynski, Tomasz; Wang, Shouao; Askari, Sorayya; Boruff, Jill; Ware, Mark; Marmorstein, Naomi; Cipriani, Andrea; Dendukuri, Nandini; Mayo, Nancy (13 February 2019). "Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood". JAMA Psychiatry. doi:10.1001/jamapsychiatry.2018.4500. Retrieved 13 February 2019.

Sometimes, products that claim to contain CBD don’t have any at all when tested, Blessing says. More commonly, though, cookies and beverages simply contain far less than 300 milligrams of CBD, which is the minimum amount she says has been found effective in the preliminary science so far. Vybes, a brand of CBD-laced drinks, has 15 milligrams of the compound in each bottle. Feelz by Chloe, a line of CBD desserts from the vegan fast-casual chain By Chloe, has said in the past that each dessert contains only 2.5 milligrams of CBD a serving.


Prolonged psychological stress may negatively impact health, and has been cited as a factor in cognitive impairment with aging, depressive illness, and expression of disease.[60] Stress management is the application of methods to either reduce stress or increase tolerance to stress. Relaxation techniques are physical methods used to relieve stress. Psychological methods include cognitive therapy, meditation, and positive thinking, which work by reducing response to stress. Improving relevant skills, such as problem solving and time management skills, reduces uncertainty and builds confidence, which also reduces the reaction to stress-causing situations where those skills are applicable. 

An absence of such fiber-strain traits as tallness, limited branching, long internodes, and very hollow stems, is characteristic of narcotic strains. Drug forms have historically been grown in areas south of the north-temperate zone, often close to the equator, and are photoperiodically adapted to a long season. When grown in north-temperate climates maturation is much-delayed until late fall, or the plants succumb to cold weather before they are able to produce seeds. Unlike fiber strains that have been selected to grow well at extremely high densities, drug strains tend to be less persistent when grown in high concentration (de Meijer 1994). Drug strains can be very similar in appearance to fiber strains. However, a characteristic type of narcotic plant was selected in southern Asia, particularly in India and neighboring countries. This is dioecious, short (about a meter in height), highly branched, with large leaves (i.e. wide leaflets), and it is slow to mature. The appearance is rather like a short, conical Christmas tree.
Cannabis use is associated with increased recruitment of task-related areas, such as the dorsolateral prefrontal cortex, which is thought to reflect compensatory activity due to reduced processing efficiency.[114][113][116] Cannabis use is also associated with downregulation of CB1 receptors. The magnitude of down regulation is associated with cumulative cannabis exposure, and is reversed after one month of abstinence.[117][118][119] There is limited evidence that chronic cannabis use can reduce levels of glutamate metabolites in the human brain.[120]

Marijuana is the only major drug of abuse grown within the U.S. borders.  The DEA is aggressively striving to halt the spread of cannabis cultivation in the United States.  To accomplish this, the DEA initiated the Domestic Cannabis Eradication/Suppression Program (DCE/SP), which is the only nationwide law enforcement program that exclusively targets Drug Trafficking Organizations (DTO) involved in cannabis cultivation. 


Did you get an answer for this? I have the exact same scenario. I'm treating my TN with Tegretol, and recently tried CBD. I think I took too much and there are some weird drug interactions with Tegretol and I felt quite stoned....was alone and talking to myself in my head thinking I was Einstein. It freaked me out a bit but I think I took too much. I'm trying lower doses again as recently my TN seems to be resisting the meds, although I have had a lot of emotional stress, which seems to be a trigger. Thanks!! Anna
Researchers in New Zealand have studied whether cannabis can be used to treat severe motor and vocal tics in those suffering from Tourette syndrome. The study concluded that subjects who took a controlled THC-CBD medicated spray showed marked improvement in the frequency and severity of motor and vocal tics post-treatment. Although the study is only a small clinical trial, it is one of the first to specifically analyze the effects of cannabis on Tourette syndrome.
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