Interactions between medications are very common, especially in elderly populations that medicate for pain, diabetes and high cholesterol. The geriatric population is also the fastest-growing group of medical cannabis users. Cannabis has demonstrated efficacy in treating pain, and some phytocannabinoids have been suggested for various metabolic conditions. Thus it is important to understand how... Read more
Although marijuana smoke contains a number of carcinogens findings from a limited number of well-designed studies do not suggest an increased risk for the development of either lung or upper airway cancer from light or moderate use. However, the evidence is mixed when it comes to the carcinogenic risks of heavy, long-term marijuana users, according to this study.
Berenson looks, too, at the early results from the state of Washington, which, in 2014, became the first U.S. jurisdiction to legalize recreational marijuana. Between 2013 and 2017, the state’s aggravated-assault rate rose seventeen per cent, which was nearly twice the increase seen nationwide, and the murder rate rose forty-four per cent, which was more than twice the increase nationwide. We don’t know that an increase in cannabis use was responsible for that surge in violence. Berenson, though, finds it strange that, at a time when Washington may have exposed its population to higher levels of what is widely assumed to be a calming substance, its citizens began turning on one another with increased aggression.
A wide variety of hemp clothing, footwear, and food products are now available in North America. Some American manufacturers and distributors have chosen to exploit the association of hemp products with marijuana in their advertising. Such marketing is unfortunate, sending the message that some in the industry are indifferent to the negative image that this generates in the minds of much of the potential consuming public. Admittedly, such advertising works. But marketing based on the healthful and tasteful properties of hemp food products, the durable nature of hemp textiles, and the environmental advantages of the crop has proven to be widely acceptable, and is likely to promote the long term development of hemp industries.
At an epidemiological level, a dose–response relationship exists between cannabis use and increased risk of psychosis and earlier onset of psychosis. Although the epidemiological association is robust, evidence to prove a causal relationship is lacking. But a biological causal pathway is plausible, especially if there is a genetic predisposition to mental illness, in which case cannabis may be a trigger.[better source needed]
Extraction: The method by which CBD oil is processed from hemp plants can be very telling. Some manufacturers extract and process the oil using toxic materials like propane or butane; in most cases, these oils are cheaply priced. Safer extraction and processing agents include ethanol, which cleans the hemp plant of unwanted toxins; and supercritical carbon dioxide extraction, which strips harmful materials from the plant by changing the carbon dioxide’s temperature and pressure settings.
The reason so many people are interested in cannabis products that don’t make them high, proponents say, is that CBD helps with everything from pain and nausea to rheumatoid arthritis, cancer, Crohn’s disease, and dementia. CBD is anti-inflammatory, anti-anxiety, antibacterial, immunosuppressive, and more, says Joseph Cohen, D.O., a cannabis doctor in Boulder, CO.
The major symptom of many short and long-term illnesses is pain, both chronic and acute. Disorders such as Multiple Sclerosis, Diabetic Neuropathy and others, whether derived from the primary or central nervous system, leave patients with unrelenting pain not easily controlled by common pain medications. Although few randomized clinical trials over sufficiently extended periods of time measuring the effects of cannabidiol oil intake on pain management exist, preliminary studies suggest the use of CBD’s in chronic pain management to be useful allowing an increase in quality of life and the ability to rest without pain. There is some research out there that suggests this might be a good solution for those that are sensitive to other medications as well. We have attached some Medical publications, News Articles and some videos that touch on this subject.
Hemp CBD oil is not regulated, creating a situation of buyer beware. Despite this, hemp CBD oil continues to be in high demand as a growing number of chronic pain patients look for alternatives to opioids and drugs with troubling side effects. With so many companies pushing their products, how can you ensure you’re purchasing a quality product that’s potent and safe to use?
For those wondering does hemp CBD oil for pain relief really work? There have been many studies that have demonstrated that using CBD is one of the most effective means of helping people who are suffering from chronic forms of pain. For those who have had injuries or ailments that have caused debilitating pain even for a short period of time, there is truly nothing they want more than to see this pain reduced, if not removed all together. This has been of the great benefits of cannabidiol oil.
In the dozen years since e-cigarettes were introduced into the marketplace, they have attracted an enormous amount of attention. There are scores of studies and papers on the subject in the medical and legal literature, grappling with the questions raised by the new technology. Vaping is clearly popular among kids. Is it a gateway to traditional tobacco use? Some public-health experts worry that we’re grooming a younger generation for a lifetime of dangerous addiction. Yet other people see e-cigarettes as a much safer alternative for adult smokers looking to satisfy their nicotine addiction. That’s the British perspective. Last year, a Parliamentary committee recommended cutting taxes on e-cigarettes and allowing vaping in areas where it had previously been banned. Since e-cigarettes are as much as ninety-five per cent less harmful than regular cigarettes, the committee argued, why not promote them? Gottlieb said that he was splitting the difference between the two positions—giving adults “opportunities to transition to non-combustible products,” while upholding the F.D.A.’s “solemn mandate to make nicotine products less accessible and less appealing to children.” He was immediately criticized.
In a report published in Pediatric Dermatology in 2018, scientists reported three cases of topical CBD (applied as an oil, cream, and spray) use in children with a rare, blistering skin condition known as epidermolysis bullosa. Applied by their parents, all three people reported faster wound healing, less blisters, and improvement of pain. One person was able to completely wean off oral opioid analgesic pain medication. There were no adverse effects reported.
Hemp, grown under license mostly in Canada, is the most publicized “new” crop in North America. Until very recently the prohibition against drug forms of the plant prevented consideration of cultivation of fiber and oilseed cultivars in Canada. However, in the last 10 years three key developments occurred: (1) much-publicized recent advances in the legal cultivation of hemp in western Europe, especially for new value-added products; (2) enterprising farmers and farm groups became convinced of the agricultural potential of hemp in Canada, and obtained permits to conduct experimental cultivation; and (3) lobby groups convinced the government of Canada that narcotic forms of the hemp plant are distinct and distinguishable from fiber and oilseed forms. In March 1998, new regulations (under the Controlled Drugs and Substances Act) were provided to allow the commercial development of a hemp industry in Canada, and since then more than a thousand licenses have been issued. Hectares licensed for cultivation for 1998–2001 were respectively, 2,500, 14,200, 5,487, and 1,355, the decreasing trend due to a glut of seed produced in 1999 and pessimism over new potential regulations barring exports to the US. Information on the commercial potential of hemp in Canada is in Blade (1998), Marcus (1998), and Pinfold Consulting (1998). In the US, a substantial trade in hemp products has developed, based on imports of hemp fiber, grain, and oil. The American agricultural community has observed this, and has had success at the state level in persuading legislators of the advisability of experimental hemp cultivation as a means of evaluating the wisdom of re-establishing American hemp production. However, because of opposition by the federal government, to date there has only been a small experimental plot in Hawaii. Information on the commercial potential of hemp in the US is presented in the following.
My daughter has been in a bad car accident over a month ago & the airbag made her stomach hernia worse. She has been in extreme pain & nothing helps so last week she had one side of her stomach nerves burned -but it hasn’t helped. Tomorrow she is having the other side done. I told her to try this but she has to get the doctor to Ok it I guess. I hope he says OK & lets her. She wants to know if it takes time to take effect & if it will mix with other pain meds.
The US Drug Enforcement Administration’s online criminal justice statistics for 2000 (cscmosaic.albany.edu/sourcebook/1995/pdf/t440.pdf) shows the following seizures and eradication of plants of C. sativa: 40,929 outdoor plots (2,597,796 plants), 139,580,728 ditchweed (ruderal plants), 2,361 indoor operations (217,105 plants), for a grand total of 2,814, 903 plants destroyed. Impressively, the species was grown in all 50 states (including outdoor seizures in every state except Wyoming)! It is of course impossible to know exactly how much marijuana is cultivated in the United States, and perhaps only 10% to 20% of the amount grown is seized. The profitability of the illegal crop is indicated by a comparison of the cost of a bushel of corn (roughly $2.50) and a bushel of manicured marijuana (about $70,000; it has been suggested that prices range from $500 a pound, for low-quality marijuana, to more than $5,000 a pound for “boutique” strains like “Northern Lights” and “Afghan Kush”). According to a National Organization for the Reform of Marijuana Laws (NORML) (mir.drugtext.org/marijuananews/marijuana_ranks_fourth_largest_c.htm) marijuana is at least the fourth most valuable crop in America, outranked only by corn, soybeans, and hay. It was estimated that 8.7 million marijuana plants were harvested in 1997, worth $15.1 billion to growers and $25.2 billion on the retail market (the wholesale value was used to compare marijuana to other cash crops). Marijuana was judged to be the largest revenue producing crop in Alabama, California, Colorado, Hawaii, Kentucky, Maine, Rhode Island, Tennessee, Virginia, and West Virginia, and one of the top five cash crops in 29 other states.
This article reviews recent research on cannabinoid analgesia via the endocannabinoid system and non-receptor mechanisms, as well as randomized clinical trials employing cannabinoids in pain treatment. Tetrahydrocannabinol (THC, Marinol®) and nabilone (Cesamet®) are currently approved in the United States and other countries, but not for pain indications. Other synthetic cannabinoids, such as ajulemic acid, are in development. Crude herbal cannabis remains illegal in most jurisdictions but is also under investigation. Sativex®, a cannabis derived oromucosal spray containing equal proportions of THC (partial CB1 receptor agonist ) and cannabidiol (CBD, a non-euphoriant, anti-inflammatory analgesic with CB1 receptor antagonist and endocannabinoid modulating effects) was approved in Canada in 2005 for treatment of central neuropathic pain in multiple sclerosis, and in 2007 for intractable cancer pain. Numerous randomized clinical trials have demonstrated safety and efficacy for Sativex in central and peripheral neuropathic pain, rheumatoid arthritis and cancer pain. An Investigational New Drug application to conduct advanced clinical trials for cancer pain was approved by the US FDA in January 2006. Cannabinoid analgesics have generally been well tolerated in clinical trials with acceptable adverse event profiles. Their adjunctive addition to the pharmacological armamentarium for treatment of pain shows great promise.
Systematic activities to prevent or cure health problems and promote good health in humans are undertaken by health care providers. Applications with regard to animal health are covered by the veterinary sciences. The term "healthy" is also widely used in the context of many types of non-living organizations and their impacts for the benefit of humans, such as in the sense of healthy communities, healthy cities or healthy environments. In addition to health care interventions and a person's surroundings, a number of other factors are known to influence the health status of individuals, including their background, lifestyle, and economic, social conditions and spirituality; these are referred to as "determinants of health." Studies have shown that high levels of stress can affect human health.
Van Roekel (1994) has pointed out that Egyptian papyrus sheets are not “paper,” because the fiber strands are woven, not “wet-laid;” the oldest surviving paper is over 2,000 years of age, from China, and was made from hemp fiber (Fleming and Clarke 1998). Until the early 19th century, hemp, and flax were the chief paper-making materials. In historical times, hemp rag was processed into paper. Using hemp directly for paper was considered too expensive, and in any event the demand for paper was far more limited than today. Wood-based paper came into use when mechanical and chemical pulping was developed in the mid 1800s in Germany and England. Today, at least 95% of paper is made from wood pulp.
The use of Cannabis for seed oil (Fig. 36) began at least 3 millennia ago. Hempseed oil is a drying oil, formerly used in paints and varnishes and in the manufacture of soap. Present cultivation of oilseed hemp is not competitive with linseed for production of oil for manufacturing, or to sunflower and canola for edible vegetable oil. However, as noted below, there are remarkable dietary advantages to hempseed oil, which accordingly has good potential for penetrating the salad oil market, and for use in a very wide variety of food products. There is also good potential for hemp oil in cosmetics and skin-care products.
In the meantime, some physicians are forging ahead — and cashing in. Joe Cohen is a doctor at Holos Health, a medical marijuana clinic in Boulder. I asked him what CBD is good for, and he read me a long list of conditions: pain, inflammation, nausea, vomiting, intestinal cramping, anxiety, psychosis, muscle spasms, hyperactive immune systems, nervous system degeneration, elevated blood sugar and more. He also claimed that CBD has anti-cancer properties and can regenerate brain cells and reduce the brain’s levels of amyloid beta — a kind of protein that’s been linked to Alzheimer’s disease. I asked for references, noting that most of these weren’t listed in the Academies report or a similar review published in the Journal of the American Medical Association. “I think you just have to Google search it,” he said. It’s true that a preliminary study found hints that cannabinoids might reduce beta amyloid proteins in human brain cells, but the study was done in cells grown in a lab, not in people. As for cancer, the FDA sent warning letters last year to four companies that were selling products that claimed to “prevent, diagnose, treat or cure” cancer.
The vast majority of subjects in Sativex clinical trials do not experience psychotropic effects outside of initial dose titration intervals (Figure 2) and most often report subjective intoxication levels on visual analogue scales that are indistinguishable from placebo, in the single digits out of 100 (Wade et al 2006). Thus, it is now longer tenable to claim that psychoactive effects are a necessary prerequisite to symptom relief in the therapeutic setting with a standardized intermediate onset cannabis-based preparation. Intoxication has remained a persistent issue in Marinol usage (Calhoun et al 1998), in contrast.
The environment in which hemp and marijuana are grown is strikingly different. Hemp is grown closely together (as close as 4 inches apart) and are typically grown in large multi-acre plots. It can also grow in variety of climates and its growth cycle is 108-120 days. Unlike hemp, marijuana requires a carefully controlled, warm, and humid atmostphere for proper growth. Its growth cycle only 60-90 days. Medical cannabis also cannot be grown too close to each other. They are typically grown 6 feet apart. If, somehow, marijuana grows among (or close to) a hemp field, the hemp’s pollen would immediateately ruin the marijuana crop, diluting marijuana’s psychoactivity.
While CBD is considered the major non-psychoactive component of cannabis, in studies using varied doses, routes of administration, and combination or whole products with THC, a number of side effects have been reported, including anxiety, changes in appetite and mood, diarrhea, dizziness, drowsiness, dry mouth, low blood pressure, mental confusion, nausea, and vomiting.
A chief argument that has been advanced in favor of developing hemp as a paper and pulp source has been that as a non-wood or tree-free fiber source, it can reduce harvesting of primary forests and the threat to associated biodiversity. It has been claimed that hemp produces three to four times as much useable fiber per hectare per annum as forests. However, Wong (1998) notes evidence that in the southern US hemp would produce only twice as much pulp as does a pine plantation (but see discussion below on suitability of hemp as a potential lumber substitute in areas lacking trees).
That’s our two cents worth. We are still reserching products with claims of effective pain relief and possibly something will work. As of right now if dot/gov can not point the now abandoned pain management patient to an effective pain management product, not willing to listen to our physicians or VERY negatively affected patients with a maximum, unilateral dosage of opioid medication new “policy”, then where do we turn for real, effective, pain management?
Hempseed's amino acid profile is comparable to other sources of protein such as meat, milk, eggs and soy. Protein digestibility-corrected amino acid scores (PDCAAS), which attempt to measure the degree to which a food for humans is a "complete protein", were 0.49–0.53 for whole hemp seed, 0.46–0.51 for hempseed meal, and 0.63–0.66 for hulled hempseed.
CBD Isolates/Concentrates: Anyone familiar with smoking hash or other cannabis concentrates like wax and BHO will be no stranger to this delivery method. Simply sprinkle some into a vaporizer or water pipe, ignite, inhale, and enjoy! We find that this option is useful for individuals looking to elevate their regular consumption of CBD-rich cannabis flowers or other smokable herbs.
Right now, there’s a good chance that you don’t really know what you’re getting from any source. Testing and labeling rules vary by state, but many states that allow legal cannabis also require some kind of testing to verify that the THC and CBD levels listed on the label are accurate. However, this testing is controversial, and results can vary widely between labs, Jikomes said. A study published in March found measurable variations in test results, with some labs consistently reporting higher or lower levels of cannabinoids than others. There are no guarantees that the label accurately reflects what’s in the product. For a 2015 study published in JAMA, researchers tested 75 products purchased in San Francisco, Los Angeles and Seattle and found that only 17 percent were accurately labeled. More than half of the products contained significantly lower levels of cannabinoids than the label promised, and some of them contained only negligible amounts of the compounds. “We need to come up with ways to confidently verify the composition of cannabis products and make this information available to consumers,” Jikomes said.
"Many EU countries lifted their bans on hemp production in the 1990s and, until recently, also subsidized the production of 'flax and hemp' under the EU’s Common Agricultural Policy.32 EU hemp acreage was reported at about 26,000 acres in 2010, which was below previous years, when more than 50,000 acres of hemp were under production.33 Most EU production is of hurds, seeds, and fibers. Other non-EU European countries with reported hemp production include Russia, Ukraine, and Switzerland. Other countries with active hemp grower and/or consumer markets are Australia, New Zealand, India, Japan, Korea, Turkey, Egypt, Chile, and Thailand."
In addition to the daily pain management program outlined above, many people find they still need a safe way to manage acute flare ups. Whether it’s caused by a recent injury, cold weather, or general aggravation – we recommend vaporizing CBD isolate to combat these acute pain flare ups. The benefit of vaporizing or dabbing CBD isolate is that the relief can be felt almost instantaneously. CBD isolate is 99% pure CBD and provides a wave of relief that can be felt throughout the whole body.
There are many varieties of cannabis infusions owing to the variety of non-volatile solvents used. The plant material is mixed with the solvent and then pressed and filtered to express the oils of the plant into the solvent. Examples of solvents used in this process are cocoa butter, dairy butter, cooking oil, glycerine, and skin moisturizers. Depending on the solvent, these may be used in cannabis foods or applied topically.
There is some speculation that George Washington smoked the flower of the cannabis plant in order to achieve a recreational high ("Like all farmers, Washington probably sampled the quality and potency of what he grew, and he may have used this hemp to treat his chronic tooth aches"), but there is no evidence in any of his writings that he grew hemp for anything other than industrial purposes. It is sometimes supposed that an excerpt from Washington's diary, which reads "Began to seperate [sic] the Male from the Female hemp at Do.&—rather too late" is evidence that he was trying to grow female plants for the THC found in the flowers. However, the editorial remark accompanying the diary states that "This may arise from their [the male] being coarser, and the stalks larger" In subsequent days, he describes soaking the hemp (to make the fibers usable) and harvesting the seeds, suggesting that he was growing hemp for industrial purposes, not recreational.
CBD is a compound called a cannabinoid, says Jordan Tishler, MD, a Harvard-trained doc who is an expert on using cannabis as medical treatment. It can be extracted from hemp or marijuana, two different plants from the Cannabis sativa L. ("cannabis") species. The big difference between the two: Marijuana contains higher levels of tetrahydrocannabinol ("THC"), the compound responsible for the psychoactive properties of pot (a.k.a., the stuff that makes you high). Hemp, on the other hand, is naturally very low in THC (0.3 percent), says Tishler.
Although CBD oils aren’t regulated by the FDA, purchasing products stateside from one of the nine states where recreational and medical cannabis use is legal will likely result in a higher-quality product than buying one made with hemp-derived CBD oil imported from abroad, says Martin Lee, director of Project CBD, a nonprofit that promotes medical research into CBD.
"Hemp seeds represent the manufacturing starting point for the vast majority of hemp products marketed since the mid-1990s. Hemp seeds are a good source of essential fatty acids, primarily alpha-linolenic acid (omega-3) and ]inoleic acid (omega-6). They are also found in fish, flaxseed, rapeseed oil, pumpkin seeds, and sunflowerseeds. Essential fatty acids (EFA) are necessary fats that humans cannot synthesize, so they must be obtained through diet. EFAs support the cardiovascular, reproductive,immune, and nervous systems. The human body needs EFAs to manufacture and repair cell membranes, enabling the cells to obtain optimum nutrition and expel harmful waste products (9). THC found in manufactured products is present via contamination from resin produced in the leaves and buds that come into contact with the seed shell. Seed decontamination and manufacturing processes including wash steps and cold pressing for hemp products have improved since the mid-1990s, leading to the much lower THC concentrations currently found in today's commercial products.
^ Fusar-Poli, Paolo; Crippa, José A.; Bhattacharyya, Sagnik; Borgwardt, Stefan J.; Allen, Paul; Martin-Santos, Rocio; Seal, Marc; Surguladze, Simon A.; O'Carrol, Colin; Atakan, Zerrin; Zuardi, Antonio W.; McGuire, Philip K. (2009). "Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing". Archives of General Psychiatry. 66 (1): 95–105. doi:10.1001/archgenpsychiatry.2008.519. PMID 19124693.
Though use of marijuana among Washington state youth has remained relatively stable over the last several years (see Healthy Youth Survey), youth perception of harm from use of marijuana has been steadily decreasing (meaning: fewer adolescents believe marijuana use is harmful). Marijuana is the second most-commonly used substance among 12th graders (alcohol is the first), with 27% of high school seniors reporting current (past 30-day) use.
"Approximately 30 countries in Europe, Asia, and North and South America currently permit farmers to grow hemp. Some of these countries never outlawed production, while some countries banned production for certain periods in the past. China is among the largest producing and exporting countries of hemp textiles and related products, as well as a major supplier of these products to the United States. The European Union (EU) has an active hemp market, with production in most member nations. Production is centered in France, the United Kingdom, Romania, and Hungary.30
Cannabis flavonoids in whole cannabis extracts may also contribute useful activity (McPartland and Russo 2001). Apigenin inhibits TNF-α (Gerritsen et al 1995), a mechanism germane to multiple sclerosis and rheumatoid arthritis. Cannflavin A, a flavone unique to cannabis, inhibits PGE-2 thirty times more potently than aspirin (Barrett et al 1986), but has not been subsequently investigated.
High-CBD strains tend to deliver very clear-headed, functional effects without the euphoric high associated with high-THC strains. They’re typically preferred by consumers who are extremely sensitive to the side effects of THC (e.g., anxiety, paranoia, dizziness). A high-CBD strain would also be a great choice for someone needing to medicate throughout the day to control pain, inflammation, anxiety, or other chronic conditions.
Also high in fiber, hemp seeds are more digestible than any other high-protein food, including meat, cheese, eggs, human milk, or cows’ milk. They’re high in antioxidants, and minerals like iron, zinc and copper as well as calcium, magnesium, potassium, carotene, thiamin (vitamin B1), riboflavin (vitamin B2), vitamin B6 and vitamin E. If that’s not enough, there’s also chlorophyll, sulfur, phosphorus, phospholipids, and phytosterols.
In fact, many kinds of pains related to specific systems of the body can be managed more effectively through the use of cannabidiol oil. Many use CBD oil for muscle pain, but CBD oil for nerve pain is just as effective. What has been discovered is that the effectiveness of CBD oil for neuropathic pain in general is what is making this such a wonder remedy for so many different kinds of issues related to pain.
Only a handful of countries have legalized recreational marijuana. Uruguay was one of the first, in 2013. The Netherlands is perhaps the country most known for legal marijuana, yet the drug is illegal there. Spain has given its citizens the rights to grow and consume cannabis privately. Peru also allows citizens to possess marijuana as long as it is for personal, private use. As in Costa Rica, where people can have a “small amount,” without legal trouble.
^ Jump up to: a b Batalla A, Bhattacharyya S, Yücel M, Fusar-Poli P, Crippa JA, Nogué S, Torrens M, Pujol J, Farré M, Martin-Santos R (2013). "Structural and functional imaging studies in chronic cannabis users: a systematic review of adolescent and adult findings". PLOS One. 8 (2): e55821. Bibcode:2013PLoSO...855821B. doi:10.1371/journal.pone.0055821. PMC 3563634. PMID 23390554. The most consistently reported brain alteration was reduced hippocampal volume which was shown to persist even after several months of abstinence in one study and also to be related to the amount of cannabis use Other frequently reported morphological brain alterations related to chronic cannabis use were reported in the amygdala the cerebellum and the frontal cortex...These findings may be interpreted as reflecting neuroadaptation, perhaps indicating the recruitment of additional regions as a compensatory mechanism to maintain normal cognitive performance in response to chronic cannabis exposure, particularly within the prefrontal cortex area.
Senate Majority Leader Mitch McConnell continues to be ardently anti-marijuana, despite the success of these programs and the fact that 62% of Americans say recreational marijuana should be legal. Nevertheless, McConnell and Senate Republicans read the political tea leaves and will now recognize the important differences between marijuana and hemp. In doing so, they’re creating an exciting time for entrepreneurs, CBD advocates, and farmers across the country.
Cultivated in at least 30 countries, monikers for the hemp plant often allude to its origin or use, such as Manila hemp (abacá, Musa textilis), sisal hemp (Agave sisalana), Indian hemp (Apocynumcannabinum) and New Zealand hemp (Phormiumtenax). Worldwide, hemp seed production alone has soared from around 33,000 metric tons in the late ’90s to more than 100,000 metric tons annually between 2005 and 2011.
We need proper studies, the panel concluded, on the health effects of cannabis on children and teen-agers and pregnant women and breast-feeding mothers and “older populations” and “heavy cannabis users”; in other words, on everyone except the college student who smokes a joint once a month. The panel also called for investigation into “the pharmacokinetic and pharmacodynamic properties of cannabis, modes of delivery, different concentrations, in various populations, including the dose-response relationships of cannabis and THC or other cannabinoids.”
Cannabis use is associated with increased recruitment of task-related areas, such as the dorsolateral prefrontal cortex, which is thought to reflect compensatory activity due to reduced processing efficiency. Cannabis use is also associated with downregulation of CB1 receptors. The magnitude of down regulation is associated with cumulative cannabis exposure, and is reversed after one month of abstinence. There is limited evidence that chronic cannabis use can reduce levels of glutamate metabolites in the human brain.
I have digenerative disc disease/4 bulgin discs was taking 9---10mg hydrocodones a day... i started with 3 drops of 300mg and within 5 mins started feeling better than i have theses last 6 years or so... not only that, the inflamation has decrease substantially, i wake up with energy and have begun to work out again... if im making it seem like a miracle drug... its because it is... so the first week i took 3 drops twice a day... now 3 weeks in... im taking about 5 drops 3 times a day and zero pain pills... for the first time in years i have taken control of my life agin... not depending on doctor scripts/bills etc....