Israel, another example, has led the way with ground-breaking research into cannabis cultivation. The country recently recognized medical marijuana as an official part of the nation’s branch of agriculture. Israel is already one of the world’s leading exporters of medical-grade cannabis. Recognizing marijuana cultivation as an official branch of the country’s agriculture will open up even more funds to support Israeli cannabis farmers.
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After the Restoration of Independence in 1640, in order to recover the ailing Portuguese naval fleet, were encouraged its cultivation as the Royal Decree of D. John IV in 1656. At that time its cultivation was carried out in Trás-os-Montes, Zone Tower Moncorvo, more precisely in Vilariça Valley, fertile land for any crop irrigation, and a very large area, flat and very fertile culture still wide until the last century grew up tobacco, a plant that needs a large space to expand and grow, the area lies in the valley of Serra de Bornes.[citation needed]
Like everything else in the U.S it is buyer beware. I was told that the 30 dollar a bottle Hemp Oil, would not work becasue I was “Skeptical.” I had asked exactly these questions at a Dispensary. The CBD Craze is mostly hype. It does little or nothing for pain, or anything else. The only thing I have seen is that when it is derived from marijuana in the for of a Salve with the a small amount of THC in it, it might help with arthritis topically.
Hemp is thus profitable and sustainable, two words which have eluded many U.S. farmers as of late. Hemp cultivation could provide much-needed relief as farmers struggle to find markets for millions of bushels of crops during the trade wars. Now, instead of importing an estimated $100 million of hemp products every year, that money will go to American farmers and entrepreneurs.

NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 1,000 retail locations across the country.


"Hemp and marijuana even look and smell the same," says Tom Melton, deputy director of NC State Extension. "The difference is that hemp plants contain no more than 0.3 percent (by dry weight) of THC (tetrahydrocannabinol), the psychoactive substance found in marijuana. By comparison, marijuana typically contains 5 to 20 percent THC. You can't get high on hemp."
For those wondering does hemp CBD oil for pain relief really work? There have been many studies that have demonstrated that using CBD is one of the most effective means of helping people who are suffering from chronic forms of pain. For those who have had injuries or ailments that have caused debilitating pain even for a short period of time, there is truly nothing they want more than to see this pain reduced, if not removed all together. This has been of the great benefits of cannabidiol oil.
Senate Majority Leader Mitch McConnell continues to be ardently anti-marijuana, despite the success of these programs and the fact that 62% of Americans say recreational marijuana should be legal. Nevertheless, McConnell and Senate Republicans read the political tea leaves and will now recognize the important differences between marijuana and hemp. In doing so, they’re creating an exciting time for entrepreneurs, CBD advocates, and farmers across the country.

I use cbd oil every day. I refuse to go without it. I have no arthritic pain at all anymore. I had a hip replacement 3 years ago. I am in need of the other one to be replaced. I was laying awake crying at night because of my hip pain. After I started using the oil my hip has quit aching. I sometimes forget I even have a problem with it or my arthritis. Had I known about the oil before I had my hip replaced I never would have had the surgery. I am pain free. I use hemp oil. There are 20 mg of cannabiniol in each 1 ml dose.


^ Jump up to: a b Schreiner AM, Dunn ME (October 2012). "Residual effects of cannabis use on neurocognitive performance after prolonged abstinence: a meta-analysis". Experimental and Clinical Psychopharmacology. 20 (5): 420–429. doi:10.1037/a0029117. PMID 22731735. Therefore, results indicate evidence for small neurocognitive effects that persist after the period of acute intoxication...As hypothesized, the meta-analysis conducted on studies eval- uating users after at least 25 days of abstention found no residual effects on cognitive performance...These results fail to support the idea that heavy cannabis use may result in long-term, persistent effects on neuropsychological functioning.

...with due respect, your experience Locsta is almost precisely what happened with my....chihuahua. Degenerative disc disease, excruciating pain, prednisone worked, but couldn't keep her on it..pain killers and muscle relaxants didn't help, really thought I would have to put her down. Chi bloggers suggested CBD; gave PetReleaf a shot--like you, literally within minutes I could see the difference, in days she was pain free and now is back in charge of our world. The real key here is that with my dog, there is zero, nada, chance that there was any placebo effect...
Cannabinoid agonists produce many effects beyond those mediated directly on receptors, including anti-inflammatory effects and interactions with various other neurotransmitter systems (previously reviewed (Russo 2006a). Briefly stated, THC effects in serotonergic systems are widespread, including its ability to decrease 5-hydroxytryptamine (5-HT) release from platelets (Volfe et al 1985), increase its cerebral production and decrease synaptosomal uptake (Spadone 1991). THC may affect many mechanisms of the trigeminovascular system in migraine (Akerman et al 2003; Akerman et al 2004; Akerman et al 2007; Russo 1998; Russo 2001). Dopaminergic blocking actions of THC (Müller-Vahl et al 1999) may also contribute to analgesic benefits. 

In a Phase II double-blind, randomized, placebo-controlled, 5-week study of 56 rheumatoid arthritis patients with Sativex (Blake et al 2006), employed nocturnal treatment only to a maximum of 6 sprays per evening (16.2 mg THC + 15 mg CBD). In the final treatment week, morning pain on movement, morning pain at rest, DAS-28 measure of disease activity, and SF-MPQ pain at present all favored Sativex over placebo (Table 1).
If you live in a state where CBD is legal for your condition, it’s best to buy it from a state-regulated dispensary. But even there, oversight is uneven. “I feel safe being a cannabis consumer in Colorado, since the state tracks everything from seed to sale, but I didn’t the first few years after cannabis became legal,” when the rules were still taking shape, says Robyn Griggs Lawrence, the Boulder author of The Cannabis Kitchen Cookbook, which features recipes for cannabis edibles.
In 2015, The Hebrew University of Israel published a study that documented the potency of single-molecule CBD extract versus the potency of whole-plant CBD-rich extract. It found that extract taken from whole plant CBD-rich cannabis is therapeutically superior to single-molecule extract. The scientists behind this study noticed that science had been utilizing pure, single-molecule CBD, which resulted in a bell-shaped dose-response curve. This means that CBD’s efficacy plummets at very high and very low doses.

CBD has proven neuroprotective effects and its anti-cancer properties are being investigated at several academic research centers in the United States and elsewhere. A 2010 brain cancer study by California scientists found that CBD “enhances the inhibitory effects of THC on human glioblastoma cell proliferation and survival.” This means that CBD makes THC even more potent as an anticancer substance. Also in 2010, German researchers reported that CBD stimulates neurogenesis, the growth of new brain cells, in adult mammals.

CBD is able to reduce inflammation in the body by limiting re-uptake of the neurotransmitter adenosine. CBD does this, in part, by inhibiting equilibrative nucleoside transporter 1 (ENT1). By slowing its re-uptake, the amount of adenosine in the brain is increased which in turn impacts the activity of adenosine receptors.  These receptors, particularly the A2A receptor, play a significant role in reducing inflammation throughout the body.


Cannabis for industrial uses is valuable in tens of thousands of commercial products, especially as fibre[107] ranging from paper, cordage, construction material and textiles in general, to clothing. Hemp is stronger and longer-lasting than cotton. It also is a useful source of foodstuffs (hemp milk, hemp seed, hemp oil) and biofuels. Hemp has been used by many civilizations, from China to Europe (and later North America) during the last 12,000 years.[107][108] In modern times novel applications and improvements have been explored with modest commercial success.[109][110]
Even those who are facing issues related to mental health should consult their physician. Research studies continue to examine the effects and benefits of this drug far beyond just anxiety and depression. The benefits for those facing schizophrenia may be just the tip of the iceberg, as this may help with such conditions as mania and other forms of psychosis with further research.
Nuleaf Naturals has gained popularity with its CBD oils and transparency for its operations. The CBD oil comes in more sizes and is known for having a high concentration of CBD. For example, a small 5ml bottle has 240mg of CBD oil in its composition. It may be less powerful than top providers in this industry, but the good value for money and efficiency in pain relief will most likely convince potential customers.
The overall effect is not assured because, like cannabis — which is illegal under U.S. federal law although some states have allowed medical or recreational use — states will continue to be able to enact laws related to industrial hemp, allowing for a potential patchwork of legislation across the country. Other questions remain in terms of how exactly the Agriculture Department will regulate the plant.

^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.
A rather thorough analysis of the scope of the illicit marijuana industry in Canada for 1998 is reported at www.rcmp-grc.gc.ca/html/drugsituation.htm#Marihuana and summarized in MacLeod (1999). At least 800 tonnes (t) of marijuana were grown in Canada in 1998, representing a harvest of 4.7 million flowering plants. More than 50% of the marijuana available in Canada is grown domestically. An average mature plant was estimated to produce 170 g of “marketable substance.” The value of the Canadian crop is uncertain, but has been estimated to be in the billions of dollars annually (Heading 1998; MacLeod 1999).
^ Gobbi, Gabriella; Atkin, Tobias; Zytynski, Tomasz; Wang, Shouao; Askari, Sorayya; Boruff, Jill; Ware, Mark; Marmorstein, Naomi; Cipriani, Andrea; Dendukuri, Nandini; Mayo, Nancy (13 February 2019). "Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood". JAMA Psychiatry. doi:10.1001/jamapsychiatry.2018.4500. Retrieved 13 February 2019.

"Approximately 30 countries in Europe, Asia, and North and South America currently permit farmers to grow hemp. Some of these countries never outlawed production, while some countries banned production for certain periods in the past. China is among the largest producing and exporting countries of hemp textiles and related products, as well as a major supplier of these products to the United States. The European Union (EU) has an active hemp market, with production in most member nations. Production is centered in France, the United Kingdom, Romania, and Hungary.30

Cannabinoids may offer significant “side benefits” beyond analgesia. These include anti-emetic effects, well established with THC, but additionally demonstrated for CBD (Pertwee 2005), the ability of THC and CBD to produce apoptosis in malignant cells and inhibit cancer-induced angiogenesis (Kogan 2005; Ligresti et al 2006), as well as the neuroprotective antioxidant properties of the two substances (Hampson et al 1998), and improvements in symptomatic insomnia (Russo et al 2007).
Mike, what kind of breast cancer (invasive ductal, I presume)? How many of her lymph nodes were positive? How big was the primary tumor? Reason I ask is that in women with Stage I or IIA tumors that are estrogen-and progesterone-receptor-positive and HER2-negative (ER+/PR+/HER2-) with three or fewer positive lymph nodes, there is a genomic assay test on a sample of the tumor, called OncotypeDX, that will tell doctors whether chemo is necessary or would even work at all. Medicare covers that test 100%.That type of breast cancer mentioned above, which I had as Stage IA, is treated in postmenopausal women with anti-estrogen drugs called aromatase inhibitors(aka AIs: anastrazole, letrozole, or exemestane)which have as a side effect joint pain. CBD oil is effective for this joint pain it is not, I repeat, NOT a substitute for chemo, radiation or these anti-estrogen drugs.So don’t assume your mom’s cancer will require chemo; but if it does, CBD helps with those side effects as well. If she lives in a state where medical marijuana is legal, there are doctors who sub-specialize in certifying applications for a medical marijuana card, and in the interim before the card is issued can advise as to the appropriate dose of CBD oil (legal and over-the-counter in all 50 states). Some (though not most) medical oncologists will certify their own patients’ medical marijuana card applications so she need not seek out another doctor; and will advise the appropriate dose for her symptoms. Once she gets her card, the “budtenders” in the licensed dispensaries can advise her as to the right CBD product (with or without THC), strength, and dosage. If she lives in a state where recreational weed is legal, the “budtenders” in the marijuana shops can steer her to the right strength of CBD oil and the right dosage.

REM behavior disorder: REM behavior disorder (RBD) is a parasomnia disorder characterized by shouting, becoming physically agitated, or otherwise acting out during sleep. For many, RBD is a symptom of a larger, more serious condition or disorder, such as Alzheimer’s disease or PTSD. CBD oil minimizes the symptoms of RBD, and also alleviates the anxiety and painful symptoms that often accompany disorders that lead to RBD.
The success of the DCE/SP is directly attributed to the decision of the participating agencies to share intelligence, technology and manpower.  In many areas of the U.S., cultivators have been forced to abandon large outdoor cannabis plots in favor of smaller, better concealed illicit gardens.  Cultivators are also growing outdoor cannabis under the cover of various states legal cannabis grows.
In the United Kingdom, cultivation licences are issued by the Home Office under the Misuse of Drugs Act 1971. When grown for nondrug purposes, hemp is referred to as industrial hemp, and a common product is fibre for use in a wide variety of products, as well as the seed for nutritional aspects and for the oil. Feral hemp or ditch weed is usually a naturalized fibre or oilseed strain of Cannabis that has escaped from cultivation and is self-seeding.[91]

Like everything else in the U.S it is buyer beware. I was told that the 30 dollar a bottle Hemp Oil, would not work becasue I was “Skeptical.” I had asked exactly these questions at a Dispensary. The CBD Craze is mostly hype. It does little or nothing for pain, or anything else. The only thing I have seen is that when it is derived from marijuana in the for of a Salve with the a small amount of THC in it, it might help with arthritis topically.


Understanding CBD’s analgesic, or pain-relieving, interactions with the ECS can shed light on CBD’s other interactions and effects. Importantly, the ECS participates in our bodies’ pain processing, but when CBD is introduced to our ECS, it stops the body from absorbing a pain-regulating compound known as anandamide — one of our body’s’ own natural cannabinoid molecules. Inhibiting the absorption of this compound shunts excess quantities into the bloodstream that in turn reduces pain. One study has revealed that CBD targets alpha-3 (α3) glycine receptors to suppress chronic pain and inflammation associated with dysfunctional glycine receptors, which are an important target for pain processing in the spine. In both humans and animal models, CBD has been shown to have a variety of anti-inflammatory properties.
In states with medical cannabis laws, consumers should try to purchase cannabis from licensed suppliers who share their test results, which hopefully validate their products’ robust cannabinoid and terpenoid profiles. If you’re looking to purchase hemp through an online outlet, research your purchase beforehand to ensure that you aren’t being duped.
Researchers think that CBD interacts with receptors in your brain and immune system. Receptors are tiny proteins attached to your cells that receive chemical signals from different stimuli and help your cells respond. This creates anti-inflammatory and painkilling effects that help with pain management. This means that CBD oil may benefit people with chronic pain, such as chronic back pain.
Sativex® (GW Pharmaceuticals) is an oromucosal whole cannabis-based spray combining a CB1 partial agonist (THC) with a cannabinoid system modulator (CBD), minor cannabinoids and terpenoids plus ethanol and propylene glycol excipients and peppermint flavoring (McPartland and Russo 2001; Russo and Guy 2006). It was approved by Health Canada in June 2005 for prescription for central neuropathic pain in multiple sclerosis, and in August 2007, it was additionally approved for treatment of cancer pain unresponsive to optimized opioid therapy. Sativex is a highly standardized pharmaceutical product derived from two Cannabis sativa chemovars following Good Agricultural Practice (GAP) (de Meijer 2004), yielding Tetranabinex® (predominantly-THC extract) and Nabidiolex® (predominantly-CBD extract) in a 1:1 ratio. Each 100 μL pump-action oromucosal Sativex spray actuation provides 2.7 mg of THC and 2.5 mg of CBD. Pharmacokinetic data are available, and indicate plasma half lives of 85 minutes for THC, 130 minutes for 11-hydroxy-THC and 100 minutes for CBD (Guy and Robson 2003). Sativex effects commence in 15–40 minutes, an interval that permits symptomatic dose titration. A very favorable adverse event profile has been observed in over 2500 patient years of exposure in over 2000 experimental subjects. Patients most often ascertain an individual stable dosage within 7–10 days that provides therapeutic relief without unwanted psychotropic effects (often in the range of 8–10 sprays per day). In all RCTs, Sativex was adjunctively added to optimal drug regimens in subjects with intractable symptoms, those often termed “untreatable.” Sativex is also available by named patient prescription in the UK and the Catalonia region of Spain. An Investigational New Drug (IND) application to study Sativex in advanced clinical trials in the USA was approved by the FDA in January 2006 in patients with intractable cancer pain.

The ECS is responsible for setting the baseline activity levels of our immune system and nervous system, which then work to maintain our health. When the ECS falls out of whack, the systems that are regulated by it can begin to malfunction. CBD promotes the normal health and function of the endocannabinoid system, so it’s possible that CBD can help to alleviate the symptoms of conditions that are caused by dysfunction of the endocannabinoid system.
With that stereotype now changing in addition to the outbreak of legal marketplaces in 33 states, we’re seeing a boom in cross-industry trends where major corporate and investment players are starting to enter the cannabis sector or at least signal willingness to do so. These trends are proving so strong that companies are starting to think it’s important to get in the game or risk being left behind later. That’s why major brands are either dipping a toe into the water or laying the groundwork for a cannonball-level splash when the Green Rush finally breaks.

"Hemp hurd is composed of cellulose-rich, short fibres, and make up approximately 75% of the hemp stalk. They are spongy and absorbent, ideal characteristics in applications such as animal bedding and industrial absorbents. They may also be used to produce low-quality paper. More recently, hemp hurd has been used to produce a concrete-like substance for use in building applications, as well as for insulation and to produce fibreboard."

Whether the chronic pain is in your back, neck, hands, feet, or elsewhere – CBD can help! In order to understand how CBD helps provide pain relief, we turn to a series of medical studies that have been conducted over the past ten years. These studies evaluated CBD’s medical efficacy in treating those who suffer from various types of pain. We will address the results below.
Plant, (kingdom Plantae), any multicellular eukaryotic life-form characterized by (1) photosynthetic nutrition (a characteristic possessed by all plants except some parasitic plants and underground orchids), in which chemical energy is produced from water, minerals, and carbon dioxide with the aid of pigments and the radiant energy of the Sun, (2)…
Bruce Perlowin, CEO of Hemp, Inc, (OTC: HEMP), believes hemp legalization will drive disenfranchised farmers "back-to-the-land" now that they'll have a solid economic basis in industrial hemp to rely on. "Our strategy has been to partner with farmers across the country in states where hemp cultivation and manufacturing is legal to provide them with the infrastructure needed to make a profit off this incredible crop, and this bill will be an incredible boon for the American small family farm," Perlowin told me. "The health and wellness industries are in for a major overhaul with the massive research and development and exploration into CBD‘s, CBGs, CBN’s and 113 other cannabinoids as well as some 300 terpenes found in the industrial hemp plant."
A 2012 study reported that, “systemic and intrathecal administration of cannabidiol (CBD), a major nonpsychoactive component of marijuana, and its modified derivatives significantly suppress chronic inflammatory and neuropathic pain without causing apparent analgesic tolerance…These cannabinoids may represent a novel class of therapeutic agents for the treatment of chronic pain and other diseases…”
Yes, and no. Hemp itself is an A+plus source of omega-3 and omega-6 fatty acids. In fact, it has the 3:1 ratio of omega-6 to omega-3 that research shows is optimal for health. One of those omega-6s is GLA, or gamma linolenic acid, an anti-inflammatory. That's why hemp-based food products, like hemp hearts and hemp milk, are gaining reps as legit superfoods.
Hemp isn’t completely absent of psychoactive compounds, but that doesn’t mean it will get you high. Hemp plants simply don’t produce enough THC to have an intoxicating effect. CBD, though psychoactive, is a non-intoxicating cannabinoid and won’t produce any form of a euphoric high on its own. In other words, hemp has plenty of therapeutic potential, but you’ll have to look elsewhere if you want to get high.

The first time I came across CBD was when I was visiting my brother in San Antonio, Texas 2 years back. The one day I had some serious back pain, My brother's neighbour suggested that I should try CBD oil for my pain as it helps his mom with her cancer pain, and directed me to SABotanicals, a local CBD store in San Antonio where I bought a 2000mg CBD oil.In the beginning, I was a sceptic, but it worked so well that I ordered three more bottles to last me for a few months. I must say that also felt relaxed but could do my work with no issues as it didn't make me high.To date, I'm still using CBD oil for my paid and came off pain medications completely.God gave us something great!
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